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29 results for “Rodent”
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Research ArticleOpen accessIn the keywordsSelective Lymphocyte Activation and Inhibition of In Vitro Tumor Cell Growth by Novel MorphinansRicardo Gomez-Flores, Kimberly R. Vietti, William J. Dunn et al.Opioids can suppress immune functions and increase susceptibility to developing cancer and infectious diseases. Recently, novel opioid compounds have been synthesized that lack immunosuppressive effects. We evaluated the effects of morphinans with substituted pyrimidine (methyl, phenyl, hydroxy, and amino groups) and pyrazole groups on in vitro rat thymic lymphocyte and splenic macrophage functions, and tumor cell growth. We observed that … …American Journal of Immunology, Vol. 2, Issue 1 · 5 Mar 2005 · 7,078 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeurobehavioral Potential of Cod Liver Oil in Experimental Depressed Rats: Insights into Ingestive, Cognitive, and Motor FunctionsMegha Gokul, Dimple Shet, Nayanatara Arun Kumar et al.Depression-induced variations in the metabolic and neurological components have been given more attention in research. The chronic unpredictable stress rodent model mimics daily human life stressors. This study aimed to elucidate the defensive role of cod liver oil on memory, behavioral variations, and sensorimotor coordination in the Wistar rat model of comorbid depression. Wistar albino rats were categorized into the … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 6 May 2026 · 1,301 accessesView PDFCite
Research ArticleOpen accessIn the abstractPlasmodium Pre-Erythrocytic Stages: Biology, Whole Parasite Vaccines and Transgenic ModelsKota Arun Kumar, Satish MishraMalaria remains one of the world’s worst health problems, which causes 216 million new cases and approximately 655,000 deaths every year WHO World Malaria Report, 2011. Malaria transmission to the mammalian host is initiated through a mosquito bite that delivers sporozoites into the vertebrate host. The injected sporozoites are selectively targeted to liver which is the first obligatory step in … …American Journal of Immunology, Vol. 8, Issue 3 · 13 Sep 2012 · 8,263 accessesView PDFCite
Research ArticleOpen accessIn the abstractDietary β-glucan Leads to Increased TNF-α Production in the LungRadiah C. Minor, Melody L. Robinson-Wright, Morika Williams, Steven L. HurleyProblem statement: Beta (β)-glucan is notable for its ability to stimulate the immune system and as such β-glucan and products containing β-glucan are used as dietary supplements for livestock and companion animals. β-glucan has been shown to activate macrophages and neutrophils and modulate the production of certain cytokines, including the pro-inflammatory cytokine, Tumor Necrosis Factor Alpha (TNF-α). Because TNF-α is … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 2 · 11 Jun 2012 · 7,507 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Quercetin Encapsulated Liposomes via Nasal Administration: A Novel Cognitive EnhancerTerdthai Tong-un, Supaporn Muchimapura, Wathita Phachonpai, Jintanaporn WattanathornProblem statement: Demand for cognitive-enhancing drugs is growing. Numerous medicinal plants possessing antioxidant activity have received much attention as food supplement to improve cognitive function. Quercetin is a potent free radical scavenger and antioxidant. However, the limitations of quercetin: Rapidly metabolized is an obstacle to its use for a cognitive enhancer. In addition, the burden of blood brain barrier can … …American Journal of Applied Sciences, Vol. 7, Issue 7 · 31 Jul 2010 · 7,498 accessesView PDFCite
Research ArticleOpen accessIn the abstractUse of the Nasal Speculum for Rat Endotracheal IntubationKhaled R. Alzaben, Sami A. Abu-Halaweh, Abdel Karim S. Aloweidi et al.One hundred and fifty athymic nude (rnu/rnu) rats were intubated by direct visualizion of the larynx using a nasal speculum with an attached otoscope as a light source. A blunt, plastic covered stylet was introduced between the vocal cords as guide for a 16-gauge intravenous catheter which was used as an endotracheal tube. Successful intubation was performed in 148 out … …American Journal of Applied Sciences, Vol. 6, Issue 3 · 31 Mar 2009 · 8,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunodeficient Parameters in the HIV-1 Transgenic Rat ModelSulie L. Chang, Frank Ocasio, Jose A. BeltranRecently an HIV-1 transgenic (HIV-1Tg) rat model was created that carries a gag-pol-deleted HIV-1 genome under the control of the HIV-1 viral promoter. However, other viral proteins are expressed in most organs and tissues, and are found in the circulating blood. Since HIV-1 targets the immune system in humans, we examined two immunological parameters, leukocyte-endothelial adhesion (LEA) and inflammatory cytokine … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,834 accessesView PDFCite
Research ArticleOpen accessIn the abstractRapamycin Inhibits Cystogenesis by Cystic Epithelial Cells Derived from Human Autosomal Dominant Polycystic KidneysGerard Elberg, Teresa V. Lewis, Lijuan Chen, Martin A. TurmanAutosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders and carries a high health burden since it progresses to renal failure in half of the afflicted individuals by the 6th decade of life. Currently, there is no effective treatment to slow the progression of ADPKD. Rapamycin, a drug most commonly used as an immunosuppressive agent … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,101 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Characterization of Small Mammal Communities in Forest-Steppe and Steppe Landscapes of the South of Western and Central SiberiaZarina Mukhtarovna Sergazinova, Alexander Vladimirovich Makarov, Aliya Toleuzhanovna Toleuzhanova et al.This study analyzes the fauna, population, and distribution patterns of small mammals of forest-steppe and steppe landscapes of the south of Western and Central Siberia for the period between 1998 and 2021 on the basis of literature data and authors' own materials. Most of these studies were local in nature, while our work is characterized by a generalizing and comparative … …OnLine Journal of Biological Sciences, Vol. 25, Issue 1 · 4 Dec 2024 · 4,549 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite