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302 articles for “Rats”
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Research ArticleOpen accessEvery word in the titleBiochemical Alterations Induced by Amylin in Wistar RatsMohamed Mohamed Soliman, Zein Shaban IbrahimAmylin is a peptide hormone synthesized in β cells of pancreas together with insulin in response to glucose and nutrients. Amylin controls food intake and body weight but the exact mechanism is still unknown. This study aimed to examine the effects of amylin injection on hormones, metabolites and cytokines expression in rats. Wistar rats were injected amylin Intraperitoneally (IP) (10 … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 7 Jun 2013 · 6,767 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAluminium Chloride Exposure Had No Effects on the Epididymis of Wistar RatsSamuel Adeniyi Ojo, Joseph Olajide Hambolu, Sunday Samuel Adebisi, Adebayo Adekunle BuraimohAluminium is a ubiquitous element and one of the trace elements with moderate toxic effect on living organism. It is generally a recognized neurotoxin that is believed to be at the root cause of Alzheimer’s disease and third most abundant element in the earth’s crust after oxygen and silicon. Traditionally, aluminium has been considered as nontoxic to humans. However, in … …Current Research in Medicine, Vol. 3, Issue 2 · 25 Aug 2012 · 7,453 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleBilirubin Lowering Potential of Annona muricata (Linn.) In Temporary Jaundiced RatsFareed K.N. Arthur, Eric Woode, Ebenezer O. Terlabi, Christopher LarbieProblem statement: Annona muricata is used in Ghanaian traditional medicine for the treatment of jaundice. Work done has demonstrated A. muricata to be effective in treating carbon tetrachloride-and acetaminophen-induced hepatic damage, hepatic jaundice and toxicologically safe up to 1000 mg kg-1 in animals. Current study evaluated the bilirubin-lowering potential of A. muricata aqueous extract in phenylhydrazine-(40 mg kg-1) induced jaundice … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 23 May 2012 · 12,772 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAn Induced Hematoma in Caudoputamen Nuclei in Rats Causes Central Pain when the Thalamus is also Implicated and the Central Sensitization is Reversed with GabapentinP. P. Lema, P. VachonProblem statement: The objective of this study was to evaluate pain sensitisation in rats following the induction of an intracerebral hemorrhage by injecting a collagenase solution in the caudoputamen nucleus of the right basal ganglia and to evaluate gabapentin as an analgesic for central pain. Approach: Thirty male Sprague-Dawley rats weighing between 175-300 g were used. In a first experiment, … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 10 Mar 2012 · 8,167 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleErythropoietin-Like Effects of Dihydroartemisinin in Wistar Albino RatsUtoh-Nedosa Uchechukwu Anastasia, Nedosa Kenechi Stanislaus, Onyedibe Ikenna KennethArtemisinin drugs were active during the intra-erythrocytic stage of malaria parasite infection. The activity of artemisinin and synthetic endoperoxides was related to their interaction with heme. The electrophillic intermediate formed from artemisinin in the presence of heme alkylates the protein portion of hemoglobin preferentially to the heme portion. Problem statement: Since there might be an interaction between artemisinin and the … …American Journal of Agricultural and Biological Sciences, Vol. 6, Issue 4 · 9 Dec 2011 · 7,785 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleExtra-Bone Marrow Sites of Haemopoeisis: Dihydroartemisinin Effects in Wistar Albino RatsNedosa Uchechukwu Anastasia, Saleh Mohammed, Nedosa Kenechi Stanislaus et al.Problem statement: Iron is present in ferritin, the storage form of iron in the tissues; in the respiratory cytochrome enzymes; in hemoglobin of the blood and in the myoglobin of muscle Dihydroartemisinin (DHA) has been shown to interact with heme groups in vivo and in vitro. This study investigated the effects of 5 day and 7day oral dihydroartemisinin treatments on … …American Journal of Applied Sciences, Vol. 9, Issue 1 · 2 Nov 2011 · 6,826 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffects of Melatonin in Prevention of Neuropathy in STZ-Induced Diabetic RatsNasser Zangiabadi, Vahid Sheibani, Majid Asadi-Shekaari et al.Problem statement: Diabetes mellitus occurs mainly with chronic polyneuropathy, and oxidative stress plays an important role in emergence of most neurologic and behavioral changes in diabetic patients. Many studies have focused on the beneficial effects of various antioxidants such as melatonin on diabetic neuropathy. The aim of this study is to evaluate the effect of melatonin in prevention of neuropathy … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Sep 2011 · 9,358 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRespiratory Tract-Widening Effects of Dihydroartemisinin in Wistar Albino RatsUtoh-Nedosa Uchechukwu, Njoku Goddy, S. Nedosa Kenechi et al.Problem statement: Artemisinin-based anti-malarials are currently widely used in Asia and Africa. Not much is known about the systemic effect of dihydroartemisinin. This study therefore examine the effect of dihydroartemisinin on the lungs of Wistar albino rats. Approach: Five dosages of Dihydroartemisinin (DHA) were administered by oral intubation for 5 days to 5 test and 4 control Wistar albino rats. … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Aug 2011 · 7,515 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAcute and Sub-acute Toxicity of Crataegus Aronia Syn. Azarolus (L.) Whole Plant Aqueous Extract in Wistar RatsAbdullah S. ShatoorProblem statement: Hawthorn comprises more than 200 species worldwide but very few species have been used medicinally. In Mediterranean region, the predominant species of the genus Crataegus is C. aronia syn. Azarolus (L). The extracts or tinctures prepared from the leaves, flowers and/or a fruit has been used traditionally for the treatment of different diseases including different cardiovascular problems. This … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Aug 2011 · 14,660 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Verapamil on Serum Level of Salinomycin in Diabetic RatsHossein Najafzadeh, Said Reza Fatemi, Amir AshnaProblem statement: The aim of present study was evaluation function of P-glycoprotein with or without verapamil in normal and diabetic rats; which the function of P-glycoprotein was indirectly evaluated by detection of serum slainomycin concentration with HPLC method. Approach: This study was carried in 4 groups of rats including normal rats which received salinomycin and verapamil together salinomycin; and diabetic … …American Journal of Applied Sciences, Vol. 8, Issue 9 · 1 Aug 2011 · 6,823 accessesView PDFCite