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100 articles for “Protective Effect”
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Research ArticleOpen accessPhrase in the titleProtective Effects of Covalent Cross-Linking on Proteolysis of Human Coproporphyrinogen Oxidase and Implications for PorphyriaAhmed W. Jafri, Jason R. Stephenson, Justin B. Morgenthaler et al.The effects of covalent cross-linkers on the enzyme, coproporphyrinogen oxidase, had been previously studied but their role in protecting the enzyme from protease cleavage has not been evaluated. Therefore, we examined how the cross-linker bis (sulfosuccinimidyl) suberate (BS3) affects the ability of trypsin to digest purified, wild type recombinant human coproporphyrinogen oxidase and selected mutants. Following incubation, the apparent molecular … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 6,687 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleHepatoprotective Effect of N-Acetylcystiene on the Toxic Hazards of titanium Dioxide NanoparticlesHossam Fouad Attia, Mohamed Mohamed Soliman, Gamal Hassan Abdel-Rahman et al.The present study was directed to evaluate the toxic effects of orally administered titanium dioxide naonparticles (TiO2) on liver of male albino rats and to evaluate the ameliorative effects of N-acetylcysteine (NAC). Forty adult male albino rats were divided into 4 groups; control group, NAC group, TiO2 group and TiO2/ NAC group. Rats were administered either TiO2 (1200 mg kg-1 … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 26 Sep 2013 · 8,133 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleHepatoprotective Effect of Taurine Against Oxidative Stress Due to Methotrexate in RatE. Issabeagloo, M. Taghizadiyeh, P. KermanizadehProblem statement: Taurine, 2-aminoethanesulphonic acid is an essential amino acid. It is present at high concentrations in many tissues. It plays important roles in numerous physiological functions including conjugation with bile acids, modulation of calcium levels and maintenance of osmolarity, antioxidation and stabilization of membranes. Methotrexate (MTX), as the most disease modifying anti-rheumatic drug used for Rheumatoid Arthritis (RA), has … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 16 Jan 2012 · 8,495 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleCardioprotective Effect of Lagenaria siceraria (Molina) Standley (Cucurbitaceae) Fruit Juice on Doxorubicin Induced Cardiotoxicity in RatsM. Hassanpour Fard, G. Naseh, S. L. Bodhankar, M. DikshitProblem statement: The cardio toxicity of Doxorubicin (Dox) has limited its use as an anticancer drug. The aim of present study was to investigate the cardio protective effect of Lagenaria Siceraria (Cucurbitaceous) Fruit Juice (LSFJ) against the cardio toxicity of Dox in rats. Approach: Male wistar rats (250-300 g) were randomly divided into four groups. Group I- was control, Group … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 8,510 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleCytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino RatsT. S. Muralidhar, Anna Balaji, Chinmay Bandopadhyay, S. L. ShanthaProblem statement: UlGen, a Polyherbal formulation, was investigated for its possible Ulcero-protective activity in ulcerogen and Cold-restraint stress induced Wister rats (Rattus rattus). Oral administration of UlGen, at a dose of 800 mg kg-1 significantly protected the onset of cold-resistance stress induced ulcerations. Approach: It significantly inhibited gastric ulceration induced by alcohol and aspirin. Control group: Alcohol 80% induced ulcer … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 8,180 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleGastroprotective Effects of Melastoma malabathricum Aqueous Leaf Extract against Ethanol-Induced Gastric Ulcer Iin RatsFouad Hussain, Mahmood Ameen Abdulla, Suzita Mohd Noor et al.The gastro-protective effects of the aqueous leaf extract of Melastoma malabathricum was investigated against ethanol-induced gastric mucosal injuries in rats. There were four groups of adult sprague dawley rats, consisting of six rats per group. Macroscopically, oral administration of absolute ethanol to rats that had been pre-treated with only distilled water significantly produced extensive lesions of the gastric mucosa. Oral … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 7,774 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHYPOGLYCEMIC, HEPATO-RENAL AND ANTIOXIDANT POTENTIAL EFFECTS OF CHAMOMILE RECUTITA FLOWERS ETHANOLIC EXTRACT IN STREPTOZOTOCIN-DIABETIC RATSHassan Al-Musa, Fahaid AL-HashemThis study was undertaken to evaluate the hypoglycemic and hepatorenal protective effect of ethanolic extract of Chamomile recutita flowers in streptozotocin-Diabetic Rats. Before the beginning of the experiments, acute and subacute studies were carried out in control animals first to investigate the LD50 of this extract. In the experimental design, adult male albino rats were divided into five groups: (1) … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 9 Dec 2013 · 8,151 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRadiation and Thermal Effects in Experimental High Dense Metal Fuel Elements for Advanced LMFRGolovchenko YulianKnown disadvantages of high-dense α-U metal fuel (intense radiation growth and radiation swelling, poor compatibility with steel claddings) can be reduced to the minimum by "constructive" approaches based on mechanical restraint of radiation growth and swelling and also on application of protective layers on fuel columns and claddings. Effectiveness of these methods has been confirmed during irradiation of full-sized fuel … …Energy Research Journal, Vol. 4, Issue 1 · 26 Aug 2013 · 7,022 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSesame Oil As A Protective Agent Against Doxorubicin Induced Cardio Toxicity In RatKaneez F. Shad, Suhail Al-Salam, Alaaeldin A. HamzaThe therapeutic value of doxorubicin (DXO) as anticancer antibiotic is limited by its cardiotoxicity. This study aimed to investigate the protective effect of sesame oil against DXO-induced cardiotoxicity and oxidative stress. The administration of DXO (20 mg/kg) to Wister male rats, increased serum aspartate aminotransferase and creatine kinase activities (as cardiotoxicity indices) as well as cardiac malondialdehyde and protein carbonyl … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 7,670 accessesView PDFCite
Research ArticleOpen accessIn the abstractAluminium-Induced Hepatotoxicity and the Protective Role of Withania somnifera (Ashwagandha) in Wistar RatsAnchana Babu, Rekha D Kini, Nayanatara Arun Kumar, Megha GokulAluminium is a widely distributed environmental contaminant whose chronic exposure leads to accumulation in multiple organs, including the liver, resulting in oxidative stress and tissue damage. When reactive oxygen species production exceeds the body's antioxidant defense capacity, cellular injury ensues — a mechanism central to aluminium-induced hepatotoxicity. Withania somnifera (Ashwagandha), an evergreen herb of the Solanaceae family widely cultivated in … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 6 Apr 2026 · 1,449 accessesView PDFCite