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19 articles for “Oral Route”
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Research ArticleOpen accessIn the abstractAcute and Sub-Acute Toxicological Assessment of Aqueous Leaf Extract of Bryophyllum Pinnatum (Lam.) in Sprague-Dawley RatsRaymond Iduojemu Ozolua, Sylvester Eshiotseme Idogun, Glory Eshiagiamhe TafamelProblem statement: The aqueous leaf extract of Bryophyllum pinnatum has been reported to possess antihypertensive, antiinflammatory, antimicrobial, antidiabetic and antiulcer properties among others. Being readily available and easy to cultivate, the use of the plant in herbal medicine has been on the increase. Although there are few toxicological reports on the extract, these have not been sufficiently extensive. We therefore … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 9,385 accessesView PDFCite
Research ArticleOpen accessIn the abstractNasal Administration of Quercetin Liposomes Improves Memory Impairment and Neurodegeneration in Animal Model of Alzheimer's DiseaseTerdthai Tong-un, Supaporn Muchimapura, Jintanaporn Wattanathorn, Wathita PhachonpaiProblem statement: At present, the development of protective strategy against Alzheimer’s Disease (AD) is increasing its importance due to the high prevalence of AD, a limitation of therapeutic efficacy and its high impacts on economic and social aspects. The development of the preventive and therapeutic strategy to protect against the path physiology induced by free radicals in AD from antioxidant … …American Journal of Agricultural and Biological Sciences, Vol. 5, Issue 3 · 30 Sep 2010 · 7,746 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin Liposomes via Nasal Administration Reduce Anxiety and Depression-Like Behaviors and Enhance Cognitive Performances in RatsTerdthai Tong-Un, Panakaporn Wannanon, Jintanaporn Wattanathorn, Wathita PhachonpaiProblem statement: At present, the prevalence of neuropsychological disorders particularly anxiety, depression and dementia are increase. Many strategies have been developed in order to increase the efficiency of treatment and decrease side effects. Oxidative stress has been reported to play an important role on various path physiological states. Quercetin is a flavonoid commonly found in fruits and vegetables. It has … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 9,036 accessesView PDFCite
Research ArticleOpen accessIn the abstractProfiling and Curing from Shigella Spp Isolated from Plasmid Diarrheal PatientsMunim R. Ali, Raad N. Hasan, Ali I. Mohammed, Ahmaed A. AbbasProblem statement: Shigellosis is a common infectious disease especially in underdeveloped countries. The bacteria are primarily transmitted through the faecal-oral route. The inflammatory process of acute Shigella infection affects the colon and is characterized clinically by fever, cramping abdominal pain with frequent loose stools that might contain mucus, pus and blood. Approach: This study determined the susceptibility of Shigella isolates … …Current Research in Microbiology, Vol. 1, Issue 1 · 30 Jun 2010 · 8,430 accessesView PDFCite
Research ArticleOpen accessIn the abstractTopical Cyclosporine A in Corneal Graft RejectionMahmood Nejabat, Jafar Khoshghadam, Masoomeh Eghtedari, Hamid HosseiniCorneal graft rejection is now the most common cause of graft failure after penetrating keratoplasty. This study was designed to determine whether, addition of 2% topical cyclosporine (CSA) to local and systemic steroids in treatment of endothelial corneal allograft rejection, would improve the outcome. A prospective randomized treatment trial was carried out on 40 consecutive corneal graft recipients, presenting with … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,320 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Bovine Cartilage on the Growth of Mouse B16F10 Melanoma Cells in vitro and in vivoArax Tanelian, Dalal F. Jaber, Nayla S. Al Akl, Alexander M. AbdelnoorEarlier reports indicated that Bovine Cartilage (BC) had anti-tumor effects but only a few in vitro and in vivo investigations were conducted to assess its mechanism of action. The aim of this study was to investigate some of the proposed mechanisms of action of BC on mouse melanoma cells both in vitro and in vivo and to determine if its … …American Journal of Immunology, Vol. 12, Issue 3 · 26 Oct 2016 · 7,491 accessesView PDFCite
Research ArticleOpen accessIn the abstractCHITOSAN NANOPARTICLES AND THEIR APPLICATIONS IN DRUG DELIVERY: A REVIEWSharare Najafi, Zahra Pazhouhnia, Omid Ahmadi et al.Chitosan is one of the most popular materials in the field of drug delivery due to its adhesivity and biodegradability. Different types of Chitosan based drug carriers have been conceived for various administration routes, such as oral, nasal, transdermal, parenteral, vaginal, cervical and rectal due to its biocompatibility and biodegradability. Chitosan Nanoparticles (NPs) have long been studied as carriers for … …Current Research in Drug Discovery, Vol. 1, Issue 1 · 8 Nov 2014 · 14,780 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Chromium(VI) on Serum Iron and Removal of its Toxicity by Combining Deferasirox and Deferiprone Chelators in RatsS. Jamil A. Fatemi, Marzieh Iranmanesh, Faezeh Dahooee BaloochThe present research is aimed to characterize the potential efficiency of two chelators after chromium(VI) administration for 60 days following two doses of 15 and 30 mg kg-1 chromium(VI) per body weight daily to male rats. However, the hypothesis that the two chelators might be more efficient as combined therapy than as single therapy in removing chromium(VI) from bood serum … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 30 Oct 2013 · 7,156 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Ivermectin Pour-on Administration Against Natural Heterakis gallinarum Infestation and its Prevalence in Native PoultryM. H. Khayatnouri, Y. Garedaghi, A. R. Arbati, H. KhaliliProblem statement: One of the real problems that cause the economic prejudice in animal farms yearly is parasitic diseases. To overcome these problems the use of antiparasitic drugs is necessary. Ivermectin is a broad spectrum antiparasitic agent and different routes of its administration such as injection, oral and pour-on were used. The aims of the current study were evaluation of … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 1 · 25 May 2011 · 12,059 accessesView PDFCite