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20 articles for “Mitochondrial Function”
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Research ArticleOpen accessIn the abstractButyrate Supplementation Affects Mrna Abundance of Genes Involved in Glycolysis, Oxidative Phosphorylation and Lipogenesis in the Rumen Epithelium of Holstein Dairy CowsAnne Hermen Laarman, Louis Dionissopoulos, Ousama AlZahal et al.Energy availability in epithelial cells is a crucial link for maintaining epithelial barrier integrity; energy depletion is linked to impaired barrier function in several epithelia. This study aimed to elucidate the effects of exogenous butyrate on mRNA abundance of genes indirectly involved in rumen epithelial barrier integrity. Sixteen mid-lactation Holstein cows fed a total mixed ration received a concentrate mix … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 4 · 27 Nov 2013 · 7,519 accessesView PDFCite
Research ArticleOpen accessIn the abstractConcentration-Effect, Incidence and Mechanism of Nevirapine HepatotoxicityAdikwu Elias, Brambaifa NelsonNevirapine is a dipyridozepinone non nucleoside reverse transcriptase inhibitor approved for use in HIV-infected patients. Its efficacy has been well demonstrated in numerous clinical trials. It has activity against HIV-1 but does not have significant activity against HIV-2 or other retroviruses. Nevirapine is used as one of the components of highly active antiretroviral therapy in HIV patients and in the … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 19 Apr 2013 · 8,156 accessesView PDFCite
Research ArticleOpen accessIn the abstractMechanisms of Anti-Cancer Effects of Vernonia amygdalina Leaf ExtractUtoh-Nedosa Uchechukwu AnastasiaProblem statement: Vernonia amygdalina (V. amygdalina) has been shown to have cancer cell inhibition and cytotoxic effects. Approach: This study discusses the multi-faceted and multi-linked mechanisms by which cancer tissue inhibition and destruction is achieved by V. amygdalina leaf extract and powder (subsequently called V. amygdalina Extract). Cancer cell inhibition by V. amygdalina is suggested to occur through inhibition of … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 26 Oct 2011 · 9,090 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Porcine Mitochondrial Transcription Factor a Gene: Molecular Characterization, Radiation Hybrid Mapping and Genetic Diversity among 12 Pig BreedsTanja Kunej, Xiao-Lin Wu, Jennifer J. Michal et al.Problem statement: Mitochondrial transcription factor A (TFAM) is a nucleus-encoded protein that is a key activator of mitochondrial transcription as well as a major participant in mitochondrial genome replication. Genomic characterization of the porcine TFAM gene is, therefore, necessary to determine its involvement in regulation of fat depots and meat quality traits in pigs. Approach: Genomic DNA sequence was determined … …American Journal of Animal and Veterinary Sciences, Vol. 4, Issue 4 · 31 Dec 2009 · 6,870 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvidence of Mitochondrial Dysfunction in Autism and Implications for TreatmentDaniel A. Rossignol, J. Jeffrey BradstreetClassical mitochondrial diseases occur in a subset of individuals with autism and are usually caused by genetic anomalies or mitochondrial respiratory pathway deficits. However, in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe signs and symptoms. … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 16,373 accessesView PDFCite
Research ArticleOpen accessIn the abstractBridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and PlasticityMatthew P. Anderson, Brian S. Hooker, Martha R. HerbertWe review evidence to support a model where the disease process underlying autism may begin when an in utero or early postnatal environmental, infectious, seizure, or autoimmune insult triggers an immune response that increases reactive oxygen species (ROS) production in the brain that leads to DNA damage (nuclear and mitochondrial) and metabolic enzyme blockade and that these inflammatory and oxidative … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 17,455 accessesView PDFCite
Review ArticleOpen accessIn the abstractInitiatives to Improve the Quality of Life of HIV Positive Diagnosed Subjects: A Review of Diagnosis, Prognosis and Therapeutics under the Light of Science and EthicsMario Enrique Molina, Jeremías Abou Medelej, Jorgelina Zucchi, Carlos ManasseroThe first cases of AIDS occurred about 1981. There are not fully appropriate therapeutic interventions for treating this medical condition. People who are diagnosed HIV-positive or with AIDS suffer a poor quality of life and receive medication that produces severe adverse reactions. We have analyzed a significant number of papers published in several countries on these topics, and we have … …American Journal of Immunology, Vol. 13, Issue 3 · 3 Aug 2017 · 9,055 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuronal Functions of Protein Phosphatase 2AHung-Tat Leung, Ning WangReversible protein phosphorylation is a common and important form of protein posttranslational modification which determines the proteins’ activities, substrate specificity and inhibitions or degradations, depending on the specific amino acid residue, or combination of residues, being targeted. While protein phosphorylations by kinases have been well studied, the importance of protein dephosphorylation by phosphatases has emerged over the past two decades … …Neuroscience International, Vol. 4, Issue 2 · 1 Apr 2014 · 7,777 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrediction of a Putative Functional Region in the Human Bax Protein by Computational AnalysisMaría Sánchez-Aguilar, Laurence A. Marchat, Absalom ZamoranoStructural domains are relevant elements for interactions between Bcl-2 family members to regulate apoptosis and cell survival. Although BH1-BH4 domains can be identified by their sequence and selective occurrence in Bcl-2-family members, structural regions have not been entirely determined yet. The functional residues of Bax, the most representative pro-apoptotic protein of the human Bcl-2 family, remain almost unknown. Here, we … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,230 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuropsychological Dysfunction among HIV Infected Drug AbusersRamani S. Durvasula, Charles H. HinkinHuman immunodeficiency virus (HIV) has been documented to cause direct and indirect central nervous system dysfunction that can be observed as a progressive decline in neuropsychological functioning in a large proportion of persons with HIV and AIDS. Neuropsychological decline in individuals with HIV is characterized by cognitive and motor slowing, attentional deficits, executive dysfunction and memory impairment (characterized by intact … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 7,155 accessesView PDFCite