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Research ArticleOpen accessIn the keywordsTRANSCRIPTOMIC CHANGES IN RUMINAL TISSUE INDUCED BY THE PERIPARTURIENT TRANSITION IN DAIRY COWSLouis Dionissopoulos, Ousama AlZahal, Michael Alexander Steele et al.To understand how the capacity for fat metabolism (uptake, synthesis, modification) changes in rumen epithelia immediately before and after onset of lactation in dairy cows, rumen fluid Short Chain Fatty Acid (SCFA) concentrations and mRNA expression profiles of rumen epithelia was determined in twelve Holstein dairy cows at three weeks prior to calving (wk -3, n = 12), one week … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 1 · 13 Jan 2014 · 7,501 accessesView PDFCite
Research ArticleOpen accessIn the keywordsA Rough Set based Gene Expression Clustering AlgorithmJ. Jeba Emilyn, K. RamarProblem statement: Microarray technology helps in monitoring the expression levels of thousands of genes across collections of related samples. Approach: The main goal in the analysis of large and heterogeneous gene expression datasets was to identify groups of genes that get expressed in a set of experimental conditions. Results: Several clustering techniques have been proposed for identifying gene signatures and … …Journal of Computer Science, Vol. 7, Issue 7 · 28 Jun 2011 · 6,830 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAntibiotic Resistance in Co-Culture Biofilm of Listeria monocytogenes J0161Prem Saran Tirumalai, Soam PrakashProblem statement: Do naturally group-living bacteria express genes the same way as they do in lab grown pure cultures? An intriguing question. Listeria monocytogenes, a dreaded pathogen has been and continues to be a subject of study with reference to gene expressions. However, all studies concerning the gene expression of L. monocytogenes have been done on pure culture states. Our … …Current Research in Microbiology, Vol. 3, Issue 1 · 29 Mar 2012 · 10,216 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInterleukin 10 Induces the Maturation of Putative Tolerogenic Monocyte-derived Dendritic Cells as Revealed by GeneArray AnalysisMarianne A. Jakobsen, Bjarne K. MØller, Klaus Rieneck et al.IL-10 is a multifunctional cytokine with known inhibitory effect on DC maturation. In the present study, we show that the presence of IL-10 during the first 6 days of maturation of Mo-DC has severe effects on the phenotype with IL-10 treated Mo-DC retaining a high expression of factors involved in antigen uptake and having low expression of costimulatory factors and … …American Journal of Immunology, Vol. 1, Issue 4 · 31 Dec 2005 · 6,621 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Test on the Multivariate Behrens–Fisher Problem in High–Dimensional Data by Block Covariance EstimationParanut Sukcharoen, Samruam ChongcharoenIn this paper, we proposed a new testing statistic for testing the equality of mean vectors from two multivariate normal populations when the covariance matrices are unknown and unequal in high–dimensional data. A new test is proposed based on the idea of keeping more information from the sample covariance matrices as much as possible. A proposed test is invariant under … …Journal of Mathematics and Statistics, Vol. 15, Issue 1 · 2 Apr 2019 · 7,369 accessesView PDFCite
Research ArticleOpen accessIn the abstractButyrate Supplementation Affects Mrna Abundance of Genes Involved in Glycolysis, Oxidative Phosphorylation and Lipogenesis in the Rumen Epithelium of Holstein Dairy CowsAnne Hermen Laarman, Louis Dionissopoulos, Ousama AlZahal et al.Energy availability in epithelial cells is a crucial link for maintaining epithelial barrier integrity; energy depletion is linked to impaired barrier function in several epithelia. This study aimed to elucidate the effects of exogenous butyrate on mRNA abundance of genes indirectly involved in rumen epithelial barrier integrity. Sixteen mid-lactation Holstein cows fed a total mixed ration received a concentrate mix … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 4 · 27 Nov 2013 · 7,519 accessesView PDFCite
Research ArticleOpen accessIn the abstractButyrate-Mediated Genomic Changes Involved in Non-Specific Host Defenses, Matrix Remodeling and the Immune Response in the Rumen Epithelium of Cows Afflicted with Subacute Ruminal AcidosisLouis Dionissopoulos, Anne Hermen Laarman, Ousama AlZahal et al.Subacute Ruminal Acidosis (SARA) is a disorder in cattle which can lead to chronic inflammation in the rumen epithelium, known as rumenitis. Butyrate has been shown to attenuate some of the detrimental effects of inflammatory gastroenteral disorders but the molecular mechanisms mediated by butyrate have not been defined. The objective of this study was to define the inflammatory-related genomic changes … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 1 · 10 Jan 2013 · 8,059 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Gene Selection Algorithm using Bayesian Classification ApproachAlok Sharma, Kuldip K. PaliwalIn this study, we propose a new feature (or gene) selection algorithm using Bayes classification approach. The algorithm can find gene subset crucial for cancer classification problem. Problem statement: Gene identification plays important role in human cancer classification problem. Several feature selection algorithms have been proposed for analyzing and understanding influential genes using gene expression profiles. Approach: The feature selection … …American Journal of Applied Sciences, Vol. 9, Issue 1 · 24 Nov 2011 · 8,307 accessesView PDFCite
Research ArticleOpen accessIn the abstractMethamphetamine Regulation of Sulfotransferases in Rat Liver and BrainTianyan Zhou, Chaoqun Huang, Yue Chen et al.Problem statement: Sulfotransferases (SULTs) are important phase II drug metabolizing enzymes. They also regulate the biological activities of various hormones. To the best of our knowledge, psychostimulants regulation of SULTs is basically not studied except one article reported that Methamphetamine (METH) treatment induced rat amygdale rSULT1A1 mRNA 4.3 fold by using microarray method to identify a series of candidate genes … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 7,683 accessesView PDFCite
Research ArticleOpen accessIn the abstractInversion of Covariance Matrix for High Dimension DataSamruam ChongcharoenProblem statement: In the testing statistic problem for the mean vector of independent and identically distributed multivariate normal random vectors with unknown covariance matrix when the data has sample size less than the dimension n≤p, for example, the data came from DNA microarrays where a large number of gene expression levels are measured on relatively few subjects, the p×p sample … …Journal of Mathematics and Statistics, Vol. 7, Issue 3 · 27 Jul 2011 · 7,869 accessesView PDFCite