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20 articles for “Liver Injury”
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InvestigationOpen accessIn the abstractEffects of Recombinant Toxin Phospholipase D in Cardiac Muscle of RatsJoao Victor Capelli Peixoto, Fernando Augusto Lavezzo Dias, Carlos Estevan Nolf Damiani et al.Loxoceles spiders gender are worldwide spread and its bites can cause dermonecrosis or even a systemic effect (hemolysis, kidney and liver injury). It is believed that phospholipase D, the main component present in the venom, could be responsible for the injury. In this study, we used a recombinant form of phospholipase D (rLiD1) and evaluated its direct and systemic effects … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 2 Jun 2015 · 6,959 accessesView PDFCite
Research ArticleOpen accessIn the abstractHEPATOTOXIC EFFECT OF ITRACONAZOLE IN EXPERIMENTAL RATSMohammed El-Hassan Abdelmaged KemeirItraconazole is a widely used antifungal drug. In situations such as managing patients with gastrointestinal basidiobolomycosis, third of which cases world-wide occur in the southwestern region of Saudi Arabia, prolonged treatment with this drug is required. Thus, this is study was designed to investigate the hepatotoxicity of long term administration of itraconazolein in Wistar rats. Two groups of rats were … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 1 · 30 Jan 2014 · 9,049 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtection of Terminalia belerica Roxb. Against Iron Overload Induced Liver Toxicity: An Account of Its Reducing and Iron Chelating CapacityBibhabasu Hazra, Rhitajit Sarkar, Nripendranath MandalExcess iron deposition in the liver catalyses the production of Reactive Oxygen Species (ROS) which in turn initiate oxidative damage of protein and nucleic acids leading to several human diseases. The fruits of Terminalia Belerica Roxb. (TB) has been most commonly used not only in stimulating gastrointestinal health, but also in treatment of various hepatic disorders. The present study was … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,993 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Prophylactic and Therapeutic Effects of Silymarin on Diazepam-Induced Hepatotoxicity in CatsBahman Mosallanejad, Reza Avizeh, Hossien NajafzadehProblem statement: Diazepam is commonly administered for seizure control and appetite stimulant in cats. Cats may develop acute fatal hepatic necrosis after receiving oral diazepam for several days. The aim of this study was to detect the protective action of silymarin on diazepam-induced hepatotoxicity in cats. Approach: About 25 healthy cats were randomly allotted to five equal groups. Animals in … …American Journal of Applied Sciences, Vol. 8, Issue 9 · 29 Jul 2011 · 7,430 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of in vivo Antioxidant and Hepatoprotective Activity of Portulaca oleracea L. against Paracetamol-Induced Liver Toxicity in Male RatsMohamed H. AhmidaProblem statement: Oxidative stress plays a major role in paracetamol induced hepatotoxicity. Portulaca oleracea (P.O.) has been shown to exhibit antioxidant properties. The present study aimed to investigate the effect of P.O. on the oxidative stress in Paracetamol-induced hepatic toxicity in male rats. Approach: Forty male rats were divided into four groups. Group I served as control; Group II Received … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 7,329 accessesView PDFCite
Research ArticleOpen accessIn the abstractCardioprotective Effect of Cucumis trigonus Roxb on Isoproterenol-Induced Myocardial Infarction in RatB. S. Thippeswamy, S. P. Thakker, S. Tubachi et al.Problem statement: Cucumis trigonus Roxb fruit is used for various ailments in Indian traditional system of medicine such as anthelmintic, liver tonic, cardio tonic, appetizer, expectorant and intellect promoting. However, there is lack of information regarding the effect of Cucumis trigonus on the cardiac changes associated with ISO induced myocardial infarction. Approach: The present study was designed to evaluate the … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 2 · 30 Jun 2009 · 11,555 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn vitro and In vivo Antioxidant Activity of Aphanamixis polystachya BarkAlluri V. Krishnaraju, Chirravuri V. Rao, Tayi V.N. Rao et al.Problem statement: Free radical stress leads to tissue injury and progression of disease conditions such as arthritis, hemorrhagic shock, atherosclerosis, diabetes, hepatic injury, aging and ischemia, reperfusion injury of many tissues, gastritis, tumor promotion, neurodegenerative diseases and carcinogenesis. Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. Approach: Many … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 8,739 accessesView PDFCite
Research ArticleOpen accessIn the abstractCurcuma longa, Glycyrrhiza glabra and Moringa oleifera Ameliorate Diclofenac-induced Hepatoxicity in RatsAlaaeldin A. HamzaAlthough treatment with therapeutic agents may be one of the main causes of liver toxicity, there have been only limited attempts at thorough research efforts to seek solution. Diclofenac (DIC) is a widely used anti-inflammatory drug that causes liver toxicity. This DIC-induced hepatotoxicity was found to be associated with oxidative damage. In this report, extracts of herbal plants that are … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 9,618 accessesView PDFCite
Case ReportOpen accessAll words, across the recordSurvival Following Severe Paraquat Poisoning a Case Study from the Andaman and Nicobar IslandsShiv Shankar Singh, Colin Sanchez, Prasan Kumar PandaParaquat poisoning continues to pose a significant public health challenge in the Andaman and Nicobar Islands, largely due to its alarmingly high mortality rate. In this report, we present the case of a 39-year-old male farmer who ingested 30 mL of paraquat with the intent of suicide. Initially, the patient underwent prompt gastric lavage and exhibited relative stability. Upon admission, … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 22 Jan 2025 · 10,617 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordSpirulina protects against cadmium-induced hepatotoxicity in ratsAmr Amin, Alaaeldin A. Hamza, Sayel Daoud, Waleed HamzaCadmium (Cd) is an environmental and industrial cumulative pollutant that most affects many organs specially the liver. The protective effect of Spirulina, filamentous blue green algae, on Cd – induced oxidative stress and hepatotoxicity was evaluated in male rats. Oral administration of water extract of Spirulina for seven days followed by an acute toxic dose of Cd (3.5 mg kg … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 2 · 30 Jun 2006 · 11,537 accessesView PDFCite