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20 articles for “Liver Development”
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Research ArticleOpen accessIn the abstractPlasmodium Pre-Erythrocytic Stages: Biology, Whole Parasite Vaccines and Transgenic ModelsKota Arun Kumar, Satish MishraMalaria remains one of the world’s worst health problems, which causes 216 million new cases and approximately 655,000 deaths every year WHO World Malaria Report, 2011. Malaria transmission to the mammalian host is initiated through a mosquito bite that delivers sporozoites into the vertebrate host. The injected sporozoites are selectively targeted to liver which is the first obligatory step in … …American Journal of Immunology, Vol. 8, Issue 3 · 13 Sep 2012 · 8,263 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Vitro Metabolism Studies of Polybrominated Diphenyl Ethers Using Rat and Human Liver MicrosomesShun Wen Cheng, Kathleen Randall, Anne T. KotchevarA number of studies have recently reported the bioaccumulation of the commonly used fire retardants, Polybrominated Diphenyl Ethers (PBDEs), in humans and wildlife. Exposure of animals to PBDEs has been shown to result in developmental neurological, reproductive abnormalities and the disruption of endocrine function. Thyroid hormone equilibria was also shown to be altered by PBDE exposure. There is evidence that … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 3 · 30 Sep 2008 · 6,998 accessesView PDFCite
Research ArticleOpen accessIn the abstractHISTOPATHOLOGICAL CHANGES IN MICE INFECTED WITH RIVER WATER CONTAMINATED BY PASTEURELLA MULTOCIDA TYPE B:2Mohammed Muqdad Khaleel, Faez Firdaus Jesse Abdullah, Lawan Adamu et al.Haemorrhagic Septicaemia (HS) is a fatal systemic disease of bovines typified by an acute, highly fatal septicaemic disease with high morbidity and mortality. In this study, sixty five adult ICR mice were used for the study. In the first phase, 5 mice each were inoculated with 109 cfu of P. multocida type B:2 through the intraperitoneal route. After development of … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 2 · 28 Mar 2014 · 7,747 accessesView PDFCite
Research ArticleOpen accessIn the abstractClinio-Pathological Changes in Goats Challenged with Corynebacterium Peudotuberculosis and its Exotoxin (PLD)Z. K.H. Mahmood, F. F. Jesse, A. A. Saharee et al.Caseous lymphadenitis (CLA) is a chronic disease caused by Corynebacterium pseudotuberculosis. However, there is a paucity of data about the C. pseudotuberculosis exotoxin, phospholipase D (PLD) response during the course of CLA. Therefore, this study was conducted to observe the clinical signs and the cellular changes after an experimental infection of the C. pseudotuberculosis and phospholipase D challenge. Twenty six … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 3 · 26 May 2015 · 8,316 accessesView PDFCite
Research ArticleOpen accessIn the abstractEFFECT OF PIOGLITAZONE ON HEPATIC ULTRA-STRUCTURE AND METABOLIC CHANGES INDUCED BY A HIGH SUCROSE DIET IN RATSMohamed D. Morsy, Ahmed S. Khashaba, Ahmed I. Agamy, Refaat A. EidPioglitazone (Pio) is a PPAR-γ agonist insulin sensitizer has anti-inflammatory activity. Our novel aspect was to investigate its hepatic anti-inflammatory activity at the level of ultra-structure and enzymatic changes in a high sucrose diet animal model. Forty male Sprague Dawley rats were divided into four equal groups: Control; control Pio; high sucrose diet; high sucrose diet Pio treated groups. Fourteen … …American Journal of Applied Sciences, Vol. 11, Issue 7 · 23 Apr 2014 · 6,732 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntiretroviral Toxicity and Oxidative StressAdikwu Elias, Brambaifa Nelson, Deo Oputiri, Oru-Bo Precious GeoffreyAntiretroviral drugs are used for the treatment of human immunodeficiency virus, they are used as combination regimens to achieve the highest possible benefit, tolerability, compliance and to diminish the risk of resistance development. Reports from preclinical and clinical studies have linked antiretrovirals with some toxicological effects which could be associated with redox imbalance (oxidative stress). This stimulated us to review … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 20 Nov 2013 · 8,255 accessesView PDFCite
Research ArticleOpen accessIn the abstractEfficient Classification of Cancer using Support Vector Machines and Modified Extreme Learning Machine based on Analysis of Variance FeaturesA. Bharathi, A.M. NatarajanProblem statement: The primary objective is to propose efficient cancer classification techniques which provide reliable and significant classification accuracy. To achieve this primary research goal is to find the smallest set of genes that can ensure high accuracy in classification using supervised machine learning algorithms. The significance of finding the minimum subset is three fold: (a) The computational burden and … …American Journal of Applied Sciences, Vol. 8, Issue 12 · 22 Oct 2011 · 7,441 accessesView PDFCite
Research ArticleOpen accessIn the abstractPDX-1 and MafA: Key Transcription Factors in PancreasHideaki Kaneto, Takeshi Miyatsuka, Yoshihisa Nakatani, Taka-aki MatsuokaPancreatic and duodenal homeobox factor-1 (PDX-1) plays a crucial role in pancreas development, β-cell differentiation and in maintaining normal β-cell function by regulating several β-cell-related genes including insulin. PDX-1 has potency to induce insulin-producing cells in non β-cells in various tissues such as pancreas and liver and PDX-1-VP16 fusion protein more efficiently induces insulin-producing cells, especially in the presence of … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,389 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordEvaluation of Acute Oral Toxicity Induced by Tablets Based on Ethanolic Extract of Salvia dumetorum Leaves in Experimental RatsYana Levaya, Karakoz Badekova, Mussa Zholdasbayev, Gayane AtazhanovaThe aim of this study was to assess the acute oral toxicity of a solid dosage form based on Salvia dumetorum Andrz. ex Besser leaf extract (SDT5) in experimental rats. Acute toxicity was evaluated over a 14-day observation period following a single oral administration at three dose levels (500 mg/kg, 1000 mg/kg, and 2000 mg/kg), prepared in 0.5 mL of … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 23 Jun 2026 · 1,241 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordProduction and Characterization of Exopolysaccharide from Novel Bacillus sp. M3 and Evaluation on Development Sub-Chronic Aluminum Toxicity Induced Alzheimer’s Disease in Male RatsMohsen M.S. Asker, Abeer Y. Ibrahim, Manal G. Mahmoud, Saher S. MohamedThe number of patients suffering from Alzheimer’s Disease (AD) all over the world is rising continually and becomes one of the biggest challenges for most societies throughout the world. The potential of peripheral biochemical markers as complementary tools in the neuron-phsychiatric evaluation of these patients has claimed further attention. The aims of our study were to isolate the bacteria that … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 2 · 31 May 2015 · 7,216 accessesView PDFCite