HypothesisOpen accessIn the author namesCJ-023,423 (Grapiprant) a Potential Novel Active Compound with Antihyperalgetic Properties for Veterinary PatientsMario GiorgiCompanion animals are now living longer and so are more commonly manifesting age- and pain-related disease. Nonsteroidal anti-inflammatory drugs are the most used drug in osteoarthritis and inflammatory pain of various aetiologies. Despite their safety profiles have been amended from the COX-non selective to the COX-2 selective inhibitor class, some adverse effects are still of concern especially in long term … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 2 · 14 May 2015 · 8,874 accessesView PDFCite
Research ArticleOpen accessIn the author namesA Brief Overview of the Coxib Drugs in the Veterinary FieldTae-Won Kim, Mario GiorgiTraditional Non-steroidal Anti-Inflammatory Drugs (NAIDs) have been widely used to deal with many inflammatory conditions in veterinary medicine. Nowadays however, as the quality of life of animals is improved, new drug options need to be explored. In this review, the authors report on recent trends and the application of the active ingredients labeled for veterinary purposes. …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 2 · 5 Jul 2013 · 13,852 accessesView PDFCite
Research ArticleOpen accessIn the author namesFlupirtine: A Human Drug with Potential for Use in the Veterinary FieldMario Giorgi, Helen OwenFlupirtine is a nonopioid drug without antipyretic or antiphlogistic properties and with a favorable tolerability in humans. It constitutes a unique class within the group of nonsteroidal analgesics and displays a peculiar pharmacokinetic/dynamic profile that could have large potentialities of applications in the veterinary field. This review describes and evaluates the pharmacologic literature concerning flupirtine and addresses its potential in … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 4 · 1 Jan 2013 · 7,327 accessesView PDFCite
Research ArticleOpen accessIn the author namesFrom Humans to Dogs and Back: The Translational Lesson of Metronomic ChemotherapyAlessio Pierini, Guido Bocci, Mario Giorgi et al.The main priority in veterinary oncology is to maintain patient quality of life. It is important that new chemotherapy strategies aim to minimize side effects, thus making the treatment attractive for owners as well as their pets. Metronomic chemotherapy has been shown to have an important stabilizing effect on human cancer (including chemotherapy-resistant disease) resulting in prolonged clinical benefit. In … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 4 · 31 Dec 2012 · 7,738 accessesView PDFCite
Research ArticleOpen accessIn the author namesAbnormal Findings in Haemograms of Dachshund Puppies: Presumptive (Immunodeficiency) Familial DiseaseVanessa Turinelli, Alessandra Gavazza, Susanne Rushig, Mario GiorgiIn a litter of seven Dachshund puppies, one subject was stillborn and six presented with diffuse skin infections characterized by dermatitis, abscessation, pustules, crusts and ulcers. Two of the puppies were referred for further evaluation. One male puppy was referred at four months of age and a sister litter mate was referred two months later. A complete blood count, biochemical … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 3 · 9 Aug 2012 · 7,912 accessesView PDFCite
Research ArticleOpen accessIn the author namesMirtazapine in Veterinary Medicine a Pharmacological Rationale for its Application in Chronic PainMario Giorgi, Helen OwenProblem statement: Many recent studies have shown that antidepressant agents have analgesic effects in addition to their intended primary actions. The Tricyclic Antidepressants (TCAs) have been recognized as an effective first-line treatment of human neuropathic pain but unfortunately they display a wide range of side effects. Recent studies have shown that Selective Serotonin Reuptake Inhibitors (SSRI) also have potential analgesic … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 19 May 2012 · 8,189 accessesView PDFCite
Research ArticleOpen accessIn the author namesQuantification of Zolpidem in Canine PlasmaMario Giorgi, Alessandra Gavazza, Hyoin YunProblem statement: Zolpidem is a non-benzodiazepine hypnotic agent currently used in human medicine. In contrast to benzodiazepines, zolpidem preferentially binds with the GABAA complex ϖ1 receptors while poorly interacting with the other ϖ receptor complexes. Recent studies have suggested that ZP may be used to initiate sedation and diminish severe anxiety responses in dogs. The aim of the present study … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 19 Mar 2012 · 7,908 accessesView PDFCite
Research ArticleOpen accessIn the author namesTramadol Vs Tapentadol: Anew Horizon in Pain Treatment?Mario GiorgiProblem statement: Acute and chronic pain is a common presenting sign in animal species and human beings. Approach: Classical opioids provide very effective pain relief, although they may be less effective in the treatment of chronic pain due to their limited therapeutic windows and the induced opioid receptor down regulation. Atypical opioids, such as tramadol and tapentadol, have a dual … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 25 Feb 2012 · 17,871 accessesView PDFCite