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60 results for “Gene Transcription”
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Research ArticleOpen accessIn the abstractA Static Magnetic Field Exposure in Obese Mice Induced by High Fat Diet: Its Effect on T-Box15 Gene and Uncoupling Protein 1 ExpressionWidia Bela Oktaviani, Puji Sari, Luluk Yunaini et al.Increased Ca2+ cytosolic concentration caused by Static Magnetic Field (SMF) exposure modulates Tbx15 protein and Ucp1 gene interaction that is involved in the thermogenesis browning process of white adipose tissue. Activation of Tbx15 as a transcription factor that regulates the expression of the Uncoupling protein 1 (Ucp1) gene induced by SMF exposure in adipose tissue converts excess accumulated fat into … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 23 Jan 2024 · 4,521 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssociations of HSD17B1 Gene Expression with its DNA Methylation and Estradiol Level in Polycystic Ovary Syndrome Indonesian PatientsRina Puspita, Andon Hestiantoro et al.PCOS's origin and mechanism are still unknown. Epigenetics has been linked to PCOS in an increasing number of studies in recent years. The most extensively researched epigenetic alteration is DNA methylation. During organismal development, DNA methylation can control gene expression by altering transcription factor binding. The alterations in DNA methylation are directly associated with follicular development in PCOS. Studies show … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 8 Jan 2024 · 5,399 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of SBP Gene Family and Analysis of Expression Patterns Under Salt Stress in QuinoaWeihai Hou, Jianlin Wang, Zongyu Zhang et al.This study aimed to identify the Squamosa promoter Binding Protein (SBP) transcription factor from the whole genome of quinoa by analyzing its phylogenetic relationship, gene structure, chromosome location, gene replication, upstream cis-regulatory elements, tissue expression, and construction of the SBP protein interaction network, as well as the characteristics of its tissue expression pattern under salt stress. The researchers found that … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 1 · 21 Mar 2023 · 5,503 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Cinnamomum cassia Stem-Bark Extracts on the Synthesis and Secretion of Insulin in RIN-m5F CellsAnanias Hodi Kgopa, Sebolaishi Doris Makhubela, Motetelo Alfred Mogale, Leshweni Jerry ShaiCinnamomum cassia (C. cassia) crude stem-bark extracts possess some hypoglycemic properties through inhibiting the uptake of glucose by the intestines and/or enhancing insulin sensitivity. To further investigate the mechanism through which the hypoglycemic effect is exerted, this research explored the influence of the extracts of the crude stem-bark of C. cassia, with various polarities, on particular aspects of glucose consumption … …OnLine Journal of Biological Sciences, Vol. 22, Issue 2 · 5 Apr 2022 · 5,784 accessesView PDFCite
Research ArticleOpen accessIn the abstractMomordica balsamina Fruit Extracts Enhances Selected Aspects of the Insulin Synthesis/Secretion PathwayAnanias Hodi Kgopa, Leshweni Jerry Shai, Motetelo Alfred MogalePrevious studies have suggested that crude plant extracts of the anti-diabetic medicinal plant, Momordica balsamina (MB) may exert their anti-diabetic effect through either enhancement of insulin sensitivity or inhibition of intestinal glucose absorption. However, the effects of these MB extracts on insulin synthesis and secretion are not well documented in the literature. Therefore, a main purpose of the current research … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 4 · 17 Dec 2020 · 6,999 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Endoribonuclease Domain of IRE1 and its Substrate HAC1 are Structurally Linked Components of the Unfolded Protein Response in FungiLuis David Maldonado-BonillaThe unfolded protein response sustains the folding capacity of the endoplasmic reticulum under conditions that increase the activity of the secretory pathway. In fungi, the unfolded protein response exclusively depends on the kinase/endoribonuclease IRE1, which senses the accumulation of unfolded proteins in the endoplasmic reticulum lumen and catalyzes the committed step in the unconventional splicing of HAC1 mRNA that encodes … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 4 · 14 Oct 2020 · 6,541 accessesView PDFCite
Research ArticleOpen accessIn the abstractBlue and White LED Lights Enhance Biosynthesis of Rosmarinic Acid in Cell Culture of Agastache rugosaWoo Tae Park, Sun Kyung Yeo, Nam Su Kim et al.Agastache rugosa, an herbaceous Korean perennial, contains pharmacologically important phenylpropanoids such as tilianin and rosmarinic acid. However, the knowledge of biosynthesis of phenylpropanoids from A. rugosa is limited. Therefore, a study was conducted to develop an efficient protocol for in vitro regeneration of A. rugosa and to investigate the influence of three different LED light wavelengths (white, blue and red) … …OnLine Journal of Biological Sciences, Vol. 20, Issue 2 · 24 May 2020 · 6,860 accessesView PDFCite
Review ArticleOpen accessIn the abstractMicroRNA-92a: The Administrator of Certain DiseasesZhiyuan Sun, Qing Xu, Xiaoyi Tian et al.MicroRNA-92a (miR-92a) is an evolutionarily conserved noncoding small RNA that can regulate gene expression after transcription. Previous studies have found that miR-92a is overexpressed in many tumors and can regulate numerous tumor suppressor genes negatively, with relevant effects on the development of different tumors, by regulating the DUSP10/c-Jun N-terminal kinase (JNK), phosphatase and tensin homologs (PTEN)/AKT, Wnt and EP4/Notch1 signaling … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 2 · 21 May 2020 · 6,494 accessesView PDFCite
Research ArticleOpen accessIn the abstractcDNA Cloning and Characterization of the House Dust Mite Allergen Sui p 2Joshua Evans M. Bajao, John Donnie A. RamosSuidasia pontifica (Sp) is a House Dust Mite (HDM) species found in tropical urban residential areas which causes sensitization of up to 75% of allergic patients. Cloning of allergens from Sp is a significant initial step in understanding the clinical significance of this HDM species. The study describes the cloning and in silico characterization of the group 2 allergen gene … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 2 · 14 May 2020 · 7,885 accessesView PDFCite
EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,657 accessesView PDFCite