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91 articles for “Drug-Resistance”
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Research ArticleOpen accessIn the keywordsAntimicrobial Resistance of Campylobacter spp. and Arcobacter butzleri from Pets in MalaysiaMohammed Dauda Goni, Abdinasir Yusuf Osman, Saleha Abdul Aziz et al.The emergence of antimicrobial resistance in pets is not well understood and methods of surveillance are only beginning to be established in a few countries. The consequence of antimicrobial resistant Campylobacter and Arcobacter butzleri to public health is due to the propensity of the bacteria to swiftly acquire and disseminate resistance gene. Thus, making way for the emergence of new … …American Journal of Animal and Veterinary Sciences, Vol. 13, Issue 4 · 29 Nov 2018 · 7,690 accessesView PDFCite
Research ArticleOpen accessIn the keywordsKinetic Optimization of Folic Acid Polymer Conjugates for Drug TargetingJacob M. Ngoy, Sunny E. Iyuke, Clarence S. Yah, Wilhelm E. NeuseProblem statement: Folic Acid (FA) is an essential, bioavailable water soluble B-complex vitamin that helps in the replication of normal cells. It is obtained from natural sources and it deficiency can leads to oncogenic cells development. Within this frame work in mind, we designed and synthesized a new bioconjugate carrier that can enhance the effectiveness of FA. Approach: The polymeric … …American Journal of Applied Sciences, Vol. 8, Issue 6 · 13 Jun 2011 · 7,101 accessesView PDFCite
Research ArticleOpen accessIn the keywordsExogenous Pyocyanin Alters Pseudomonas aeruginosa Susceptibility to CiprofloxacinGary D. Grant, Tian Tian Zhang, Lee S. Gloyne et al.This in vitro cell-based study identified the contributing role of pyocyanin in the resistance of Pseudomonas aeruginosa to ciprofloxacin. Problem statement: P. aeruginosa is the major pathogen in the Cystic Fibrosis (CF) lung with pyocyanin being a critical component of its virulence. Prevalence is high and, once acquired, chronic infection is difficult to eliminate. Ciprofloxacin remains a crucial oral agent … …Current Research in Microbiology, Vol. 1, Issue 1 · 30 Jun 2010 · 8,792 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMolecular Genotyping of Mycobacterium tuberculosis Isolates from TurkeyBerrin Gencer, Thomas M. ShinnickTo survey the circulating strains of Mycobacterium tuberculosis in Turkey, all clinical isolates (381 patients) recovered in laboratories in six cities during one-month periods were collected and typed by IS6110-DNA fingerprinting and spoligotyping. Drug susceptibilities were also determined. About 23% of the isolates were resistant to one or more drugs and about 4% were multidrug resistant (i.e., resistant to at … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 6,731 accessesView PDFCite
Research ArticleOpen accessIn the abstractMorphological Diversity of Isolated Mycobacterial Cultures in the Republic of Kazakhstan: Implications for Diagnostics and TreatmentAssiya Borsynbayeva, Kairat Turgenbayev, Gulzhauhar Sarsenova et al.The study of mycobacterial morphology in the Republic of Kazakhstan is relevant due to the increasing burden of tuberculosis and other mycobacterial diseases. The aim of this study was to comprehensively describe the morphological characteristics of different mycobacterial species identified in Kazakhstan, which will help to improve diagnostic methods and develop new approaches to treatment. Comparative and cross-cultural analyses were … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 1 Dec 2025 · 2,203 accessesView PDFCite
Research ArticleOpen accessIn the abstractAn Integrated Framework to Predict the Strength of New SMILE Using Graph Attention NetworkSandhi Kranthi Reddy, S. V. G. ReddyMachine Learning (ML) and Deep Learning (DL) have significantly advanced various fields, including healthcare, finance, autonomous systems, and scientific research. In healthcare, these technologies have been widely applied to disease prediction, such as cancer and diabetes. However, the challenge of drug resistance persists, creating a need for more effective drugs. Developing new drugs is a complex, expensive, and time-intensive process, … …Journal of Computer Science, Vol. 21, Issue 10 · 25 Nov 2025 · 2,157 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of the Utility of MPT64, Drug Susceptibility Testing and Tuberculosis/Nontuberculous Mycobacteria Reverse Transcription Polymerase Chain Reaction for Tuberculosis Diagnosis and Efficiency Compared with Traditional CultureHo Keun Choi, Ga Yeon Kim, Tae Soung Kim, Jae Kyung KimDefining the molecular mechanisms underlying the dormant state of Mycobacterium tuberculosis (MTB) is essential for developing more effective treatments for tuberculosis (TB) infection. We investigated the positivity and resistance rates of TB tests on 6,174 samples referred to a single hospital. Of these, 342 cases (5.5%) were confirmed as positive by acid-fast bacilli staining, 243 cases (71.1%) were detected as … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 4 · 5 Dec 2024 · 4,206 accessesView PDFCite
Research ArticleOpen accessIn the abstractVirtual Screening of CPP Conjugated Peptide as QcrB BCC Protein Inhibitors of Mycobacterium tuberculosis BacteriaMuhammad Ihsan Muttaqin, Manaman Huang, Usman Sumo Friend TambunanTuberculosis is a global leading cause of death, just below COVID-19 and ranked above HIV. This disease is caused by a pathogen called Mycobacterium tuberculosis, which spreads easily through the air and is known to remain latent in most people's bodies, about a quarter of the world's population. The current problems with TB also include two main concerns: The official … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 14 Mar 2024 · 5,518 accessesView PDFCite
Research ArticleOpen accessIn the abstractColiforms Diversity and Antibiotic Resistance in Kazakhstan CheeseAnar Kuzeubayeva, Altay Ussenbayev, Ali Aydin et al.Coliform bacteria contaminate dairy products and pose public health concerns including food poisoning and toxemia. We aimed to determine the species diversity of coliforms and to evaluate the resistance to antibiotics of E. coli in various types of cheese sold by local producers in Kazakhstan. We collected 197 samples from different cheeses sold by producers in the Kostanay (n = … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 2 · 22 Feb 2024 · 5,993 accessesView PDFCite
Research ArticleOpen accessIn the abstractImplementation of Antimicrobial Stewardship Program During COVID-19 Era: Cost Effectiveness and Mortality RatesSafaa Alkhiami, Anass Qasem, Hussein Mohamed Hussein, Ali AbdallaThe growing spread of antimicrobial resistance is a major problem on a global level that has provoked several health and government organizations to call for action to counteract the problem. The frequent misuse of antibiotics is prevalent within hospital settings, especially during the COVID-19 era. The introduction of antibiotic stewardship initiatives has demonstrated the capability to decrease both unwarranted antibiotic … …American Journal of Infectious Diseases, Vol. 19, Issue 4 · 30 Jan 2024 · 6,287 accessesView PDFCite