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14 articles for “Drug Discovery and Development”
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Research ArticleOpen accessIn the abstractMolecular Medicine-Prospects and ChallengesC. N. Ramchand, R. Sripathy, N. Somashekara et al.Drug discovery and development is a process that rationally leads to instigation of compound or formulation for the treatment of particular disease/diseased condition by acting on its specific target (s). Most of the drugs identified by conventional drug discovery process were as a result of unsystematic, random and serendipitous approach. Enhancement of knowledge in the field of biotechnology, molecular biology … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 23 Feb 2012 · 7,473 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Novel Human Immunodeficiency Virus-1 Integrase Inhibitors by Shape-Based Virtual ScreeningT.K. Omprakash, A. Thamarai Selvan, A. Shahul Hameed, S.P. GeethaProblem statement: Human Immunodeficiency Virus-1 (HIV-1) is causative agent of the immune system disease, Acquired Immune Deficiency Syndrome (AIDS). Majority of anti-HIV drugs target reverse transcriptase and protease enzymes. Toxicity and development of multidrug resistant HIV-1 virus strains are the reasons for studying new targets in HIV-1 replication process for identifying novel inhibitor with low toxicity and high activity. Approach: … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Dec 2010 · 7,191 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Feasibility Study of Challenges and Opportunities in Computational Biology: A Malaysian PerspectiveR. J.A. Richard, N. SriraamThe term computational biology refers to the knowledge derived from a computer analysis of biological data that includes identification of genes in DNA sequence of different organisms, prediction of structural and functional mechanism of proteins, feature extraction and classification of genomics and proteomics. Computational biology is a rapidly developing branch of science and is highly interdisciplinary, using techniques and Concepts … …American Journal of Applied Sciences, Vol. 2, Issue 9 · 30 Sep 2005 · 6,924 accessesView PDFCite
Short CommunicationsOpen accessAll words, across the recordCytotoxicity and Apoptosis-Induction Potential of Fraction F3 from Fruits of Bersama engleriana (Melanthaceae) against Human Cervical Cancer CellsMichèle Stella Majoumouo et al.Cervical cancer is one of the most life-threatening malignancies worldwide, despite intensive research for more efficacious chemotherapeutic agents. Recent efforts geared towards eradicating the scourge of cancer have embodied a major surge of interest in natural products as promising lead molecules in pharmaceutical development and therapeutic translation. Consequently, this study aimed to assess the cytotoxicity of a previously identified plant … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,292 accessesView PDFCite