Research ArticleOpen accessIn the abstractA Bayesian Adaptive Design for Combination of Three Drugs in Cancer Phase I Clinical TrialsMourad Tighiouart, Quanlin Li, Steven Piantadosi, Andre RogatkoWe describe a Bayesian adaptive design for early phase cancer trials of a combination of three agents. This is an extension of an earlier work by the authors by allowing all three agents to vary during the trial and by assigning different drug combinations to cohorts of three patients. The primary objective is to estimate the Maximum Tolerated Dose (MTD) … …Current Research in Biostatistics, Vol. 6, Issue 1 · 25 Aug 2016 · 8,421 accessesView PDFCite
Research ArticleOpen accessIn the abstractBacteria Contaminants and their Antibiotic Sensitivity from Selected Herbal Medicinal Products from Eldoret and Mombasa, KenyaLucia Keter, Richard Too, Nicholas Mwikwabe et al.Herbal products are used worldwide for the treatment and prevention of various diseases and currently represent a substantial proportion of the global drug market. However, these products have the potential of being contaminated by different microorganisms due to poor hygienic practices during handling, processing and packaging. The main aim of this study was to evaluate microbial quality of herbal products … …Current Research in Microbiology, Vol. 7, Issue 1 · 28 Jan 2016 · 17,160 accessesView PDFCite
EditorialOpen accessIn the abstractCommentary-How do we Improve Training for Receptor Research?Marilee Ann BenoreThis issue of the American Journal of Biochemistry and Biotechnology features articles about receptor-ligand interactions that are critical to the wellbeing of all living organisms. The importance of the field of receptor research is supported by the large number of articles published in journals, the numerous specialty journals, the international conferences and the percentage of legal drugs on the market … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 4 · 8 Dec 2015 · 8,056 accessesView PDFCite
EditorialOpen accessIn the abstractUse of Design of Experiments and Manuscripts Rejection RateAydin Berenjian, Jason RyanTraditional one-variable-at-a-time method was and still is for some researchers, the general procedure to determine the optimal conditions for a chemical, biochemical or biological mechanism. According to this technique, a large number of experiments should be performed to obtain a high precision in effect assessment and also the interaction among the variables cannot be defined. To overcome the limitations of … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 2 · 8 Jun 2015 · 7,167 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDFCite
EditorialOpen accessIn the abstractAre Heat Shock Proteins Druggable Candidates?Tawanda Zininga, Addmore ShonhaiBanumathy, G., V. Singh, S.R. Pavithra and U. Tatu, 2003. Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. J. Biol. Chem., 278: 18336-18345. DOI: 10.1074/jbc.M211309200 Brehmer, D., S. Rudiger, C.S. Gassler, D. Klostermeier and L. Packschies et al., 2001. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nature Structural Molecular … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 2 Dec 2014 · 8,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractHEPATOTOXIC EFFECT OF ITRACONAZOLE IN EXPERIMENTAL RATSMohammed El-Hassan Abdelmaged KemeirItraconazole is a widely used antifungal drug. In situations such as managing patients with gastrointestinal basidiobolomycosis, third of which cases world-wide occur in the southwestern region of Saudi Arabia, prolonged treatment with this drug is required. Thus, this is study was designed to investigate the hepatotoxicity of long term administration of itraconazolein in Wistar rats. Two groups of rats were … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 1 · 30 Jan 2014 · 9,042 accessesView PDFCite
Research ArticleOpen accessIn the abstractInteraction of Momordica charantia with Metformin in Diabetic RatsTripathi Poonam, Gupta Prem Prakash, Lal Vijay KumarNow a day’s people use herb or herbal remedies along with their medication in long term treatment of various disease. Concomitant use of herb and drug can interact with each other may cause herb drug interaction. The present study was designed to investigate the possible herb drug interaction between Momordica Chrantia Fruit Juice (MCFJ) and metformin. Metformin was given orally … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 3 · 4 Sep 2013 · 10,167 accessesView PDFCite
Research ArticleOpen accessIn the abstractTramadol Vs Tapentadol: Anew Horizon in Pain Treatment?Mario GiorgiProblem statement: Acute and chronic pain is a common presenting sign in animal species and human beings. Approach: Classical opioids provide very effective pain relief, although they may be less effective in the treatment of chronic pain due to their limited therapeutic windows and the induced opioid receptor down regulation. Atypical opioids, such as tramadol and tapentadol, have a dual … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 25 Feb 2012 · 17,871 accessesView PDFCite