16 articles for “Dendritic Cell”

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EditorialOpen accessIn the abstractChasing the Fat Demon: Fat Chance, Buddy?David L. Katz, Joachim Storsberg, Christian SchmidtScience is an interesting profession. At times, one could get caught up in his or her own world of thoughts, perception, far away from reality, sometimes referred to as the proverbial ivory tower (Lederberg, 1972). Science for the sake of science is, per se, not without merit, with our fragmented understanding of a given issue providing ample justification for experimentation … …American Journal of Immunology, Vol. 13, Issue 2 · 29 May 2017 · 8,137 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRegulation of Gene Expression by β-GlucansMary O. Huff, Carolyn M. Klingeβ-D-glucans are diverse polysaccharides derived from plant cell walls, fungi and bacteria. β-D-glucans are composed of D-glucose monomers linked by (1-3) β-glycosidic bonds with varying amounts of (1-6) or (1-4) linked side chains that bind cell surface receptors ultimately triggering changes in intracellular pathways and gene transcription. β-D-glucans have anti-viral, immunomodulatory and anti-cancer activities. This article reviews the current identity … …American Journal of Immunology, Vol. 13, Issue 1 · 12 Apr 2017 · 7,557 accessesView PDF Cite

EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,629 accessesView PDF Cite

Research ArticleOpen accessIn the abstractTargeting Cellular Receptors as a Strategy for the Development of New Generation Mucosal VaccinesConstantine Bitsaktsis, Kari Wiedinger, Edmund Joseph GosselinMucosal pathogens are a primary source of infection that require the development of vaccines to induce a specific, protective and long lasting immune response. Despite an urgent need, development of effective mucosal immunization strategies has proven difficult. The literature was reviewed to elucidate cell specific targets that may be utilized to increase the immunogenicity of protective antigens through mucosal vaccination. … …American Journal of Immunology, Vol. 9, Issue 1 · 2 Feb 2013 · 7,029 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDietary supplementation with Cyperus esculentus L (tiger nut) tubers attenuated atherosclerotic lesion in apolipoprotein E knockout mouse associated with inhibition of inflammatory cell responsesMohamed L. Salem, Mohsen Zommara, K. ImaizumiAtherosclerosis is a pathological process, where recruitment of mononuclear cells results in the growth of fibro-fatty plaques. Apolipoprotein E (ApoE) is a legend for the uptake of lipoproteins, and deficiency of ApoE leads to the accumulation of low-density lipoprotein. Utilizing ApoE-/- mouse, which spontaneously develop atherosclerosis on low-fat chow diets, the present study showed that feeding these mice on a … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 10,479 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordBridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and PlasticityMatthew P. Anderson, Brian S. Hooker, Martha R. HerbertWe review evidence to support a model where the disease process underlying autism may begin when an in utero or early postnatal environmental, infectious, seizure, or autoimmune insult triggers an immune response that increases reactive oxygen species (ROS) production in the brain that leads to DNA damage (nuclear and mitochondrial) and metabolic enzyme blockade and that these inflammatory and oxidative … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 17,461 accessesView PDF Cite