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19 articles for “Defense Mechanisms”
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Research ArticleOpen accessIn the abstractCOV19-Dijkstra: A COVID-19 Propagation Model Based on Dijkstra’s AlgorithmArnaud Watusadisi Mavakala, Wilfried Yves Hamilton Adoni, Najib Ben Aoun et al.The presence of the coronavirus, known as COVID-19, has prompted several researchers to study the mode of spread and the different defense mechanisms of the virus. As a reminder, obtaining a vaccine, for which much research is being conducted around the world, is a long and expensive process and it is unlikely that the pandemic can be treated in time. … …Journal of Computer Science, Vol. 19, Issue 1 · 5 Jan 2023 · 6,606 accessesView PDFCite
Review ArticleOpen accessIn the abstractGeneration Test-Cases of Attacks in Mobile Ad Hoc NetworkSara Chadli, Mohammed Saber, Abdelhak ZiyyatThe number and increasing complexity of attacks against MANETs have grown significantly in recent years. While many security proposals have been developed. However, these proposals suffer from the problems of tests and evaluations. Among these solutions, the Intrusion Detection Systems (IDS) that can act as defense mechanisms. However, this last poses serious problems for its evaluators that need classify the … …Journal of Computer Science, Vol. 12, Issue 10 · 14 Dec 2016 · 6,522 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Duality of AIM2 Inflammasome: A Focus on its Role in Autoimmunity and Skin DiseasesMiriam CanaveseUnderstanding the inflammasome biology is one of the most exciting challenges in immuno-pharmacology. The role of the inflammasomes has been recognized in the host defense mechanism against invading pathogens and in the development of several conditions, such as cancer, auto-inflammatory, autoimmune, metabolic and neurodegenerative disorders. DNA recognition by the cells is a crucial immunological step leading to the initiation of … …American Journal of Pharmacology and Toxicology, Vol. 11, Issue 1 · 23 Apr 2016 · 7,369 accessesView PDFCite
EditorialOpen accessIn the abstractAMYOTROPHIC LATERAL SCLEROSIS: HOW TO UNDERSTAND SUCH DIVERSE AND SO ENTANGLED PHYSIOPATHOLOGY?Carlos Henrique Melo Reis, Marco Orsini, Marco Antônio Araujo Leite et al.When in 1865, JeanMartin Charcotreported patients with progressive muscular atrophysuperimposedwith spasticity of inexorable evolution as result of combinedlesions of the anterior horn and lateral column of the spinal cord, hecertainly inaugurated an attempt on the comprehension of one of the mostcomplexes neurological clinical conditions, which until today persists withimmense voids on their comprehension, regardless of the enormous advancesachieved. Astime went … …Current Research in Medicine, Vol. 5, Issue 2 · 16 Feb 2015 · 7,149 accessesView PDFCite
Research ArticleOpen accessIn the abstractButyrate-Mediated Genomic Changes Involved in Non-Specific Host Defenses, Matrix Remodeling and the Immune Response in the Rumen Epithelium of Cows Afflicted with Subacute Ruminal AcidosisLouis Dionissopoulos, Anne Hermen Laarman, Ousama AlZahal et al.Subacute Ruminal Acidosis (SARA) is a disorder in cattle which can lead to chronic inflammation in the rumen epithelium, known as rumenitis. Butyrate has been shown to attenuate some of the detrimental effects of inflammatory gastroenteral disorders but the molecular mechanisms mediated by butyrate have not been defined. The objective of this study was to define the inflammatory-related genomic changes … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 1 · 10 Jan 2013 · 8,059 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Discrete Event Simulator for Extensive Defense Mechanism for Denial of Service Attacks AnalysisMaryam Tanha, Seyed Dawood Sajjadi Torshizi, S. ShamalaProblem statement: Seeking for defense mechanisms against low rate Denial of Service (DoS) attacks as a new generation of DoS attacks has received special attention during recent years. As a decisive factor, evaluating the performance of the offered mitigation techniques based on different metrics for determining the viability and ability of these countermeasures requires more research. Approach: The development of … …American Journal of Applied Sciences, Vol. 9, Issue 6 · 21 Mar 2012 · 7,470 accessesView PDFCite
Research ArticleOpen accessIn the abstractP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,504 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormesis and Exercise: How the Cell Copes with Oxidative StressLi Li Ji, Zsolt Radak, Sataro GotoContraction-induced production of reactive oxygen and nitrogen species has been shown to cause oxidative stress to skeletal muscle, heart and other organs. As an adaptive response, muscle antioxidant defense systems are upregulated in response to exercise to restore intracellular prooxidantantioxidant homeostasis. Thus, both young and old animals and humans involved in regular exercise have shown reduced oxidative damage during acute … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,817 accessesView PDFCite
Research ArticleOpen accessIn the abstractRat Cardiomyocytes Express a Classical Epithelial Beta-DefensinAnnika Linde, Gerald H. Lushington, Frank Blecha, Tonatiuh MelgarejoBeta-defensins (BDs) are classical epithelial antimicrobial peptides of immediate importance in innate host defense. Since recent studies have suggested that certain BDs are also expressed in non-traditional tissues, including whole heart homogenate, and because effector molecules of innate immunity and inflammation can influence the development of certain cardiovascular disease processes, we hypothesized that BDs are produced by cardiomyocytes as a … …American Journal of Animal and Veterinary Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 6,994 accessesView PDFCite