16 results for “Contrast Agent”

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Research ArticleOpen accessIn the abstractDiatrizoate, Iopromide and Iotrolan Enhanced Cytotoxicity of Daunorubicin in Multidrug Resistant K562/adr Cells: Impaired the Mitochondrial and Inhibited the P-Glycoprotein FunctionNitaya Snitwongse Na Ayudhya, Samlee MankhetkornMultidrug resistance was an obstacle in cancer chemotherapy because the cells decreased their intracellular drug accumulation by energy-dependent compounds efflux pumps such as P-glycoprotein (P-gp). This study observed some iodinated radiographic contrast media, diatrizoate, iopromide and iotrolan affected the cellular energetic state and the kinetics of P-gp in drug-sensitive K562 and drug resistant K562/adr cell lines using spectrophotometer and spectrofluorometer. … …American Journal of Applied Sciences, Vol. 6, Issue 3 · 31 Mar 2009 · 7,161 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRapamycin Inhibits Cystogenesis by Cystic Epithelial Cells Derived from Human Autosomal Dominant Polycystic KidneysGerard Elberg, Teresa V. Lewis, Lijuan Chen, Martin A. TurmanAutosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders and carries a high health burden since it progresses to renal failure in half of the afflicted individuals by the 6th decade of life. Currently, there is no effective treatment to slow the progression of ADPKD. Rapamycin, a drug most commonly used as an immunosuppressive agent … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,101 accessesView PDF Cite

Research ArticleOpen accessIn the abstractGadolinium at Low Concentration Suppresses both Osteoclastic and Osteoblastic Activities in the Scales of GoldfishNobuo Suzuki, Kazuki Watanabe, Aika Sekimoto et al.For determining the effect of environmental pollutants on fish bone metabolism, we have developed an in vitro bioassay system using teleost scales that has osteoclasts, osteoblasts and bone matrix as markers: alkaline phosphatase (ALP) for osteoblasts and tartrate-resistant acid phosphatase (TRAP) for osteoclasts. Using this bioassay, the influence of gadolinium (Gd) on osteoclasts and osteoblasts of goldfish scales was examined … …American Journal of Environmental Sciences, Vol. 15, Issue 4 · 20 Sep 2019 · 8,451 accessesView PDF Cite

EditorialOpen accessIn the abstractProtecting crop species from biotic and abiotic constraints in the era of Global Change: are we ready for this challenge?Marco Landi, Giovanni BenelliReliable and affordable supply of food is of crucial importance to the progress and stability of human societies. During the last century, we have assisted to an extraordinary increase of crop yields, especially for the most widespread and consumed crop species, such as rice, wheat, corn and soybean. The Broadbalk experiment, one of the oldest continuous agronomic experiments in the … …American Journal of Agricultural and Biological Sciences, Vol. 11, Issue 2 · 4 Jun 2016 · 8,399 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCytotoxicity Studies of Superparamagnetic Iron Oxide Nanoparticles in Macrophage and Liver CellsAroonsri Priprem, Pramote Mahakunakorn, Chunpen Thomas, Ian ThomasSuperparamagnetic Iron Oxide Nanoparticles (SPIONs) prepared by simplified coprecipitation were attractive as MRI contrast agents and drug carriers which could internally be manipulated under the influence of an external magnetic field and also cancer treatment due to additional hyperthermia effects. Problem statement: Macrophage and liver cells are potentially exposed to internal SPIONs, thus used for this cytotoxic tests for safety … …Current Research in Nanotechnology, Vol. 1, Issue 2 · 22 Jun 2011 · 11,624 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRole of AP-1 Antagonism in Growth Inhibition of Cervical Cancer Cell Lines by RetinoidsShennan Lu, Doris M. BenbrookRetinoid compounds induce multiple molecular effects that need to be taken into consideration in the development of theses agents as pharmaceuticals for cancer chemoprevention. Inhibition of cancer cell growth by retinoids is thought to occur through at least two mechanisms of transcriptional regulation resulting from direct binding of retinoids to nuclear retinoid receptors (RARs and RXR’s). First, the nuclear receptors … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,477 accessesView PDF Cite