154 results for “Cancer Cell”

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Research ArticleOpen accessPhrase in the titleAntiproliferative Effects of Alkaloids Isolated from the Tuber of Stephania venosa via the Induction of Cell Cycle Arrest in Mammalian Cancer Cell LinesSirinapa Nantapap, Chatchanok Loetchutinat, Puttinan Meepowpan et al.Problem statement: S. venosa (Menispermaceae) is used in traditional medicine. The constituents of S. venosa belonging to showed remarkable cytotoxic activity. According to previous research, S. venosa contains several alkaloids, such as protoberberine stephanine cyclanoline and N-methylstepholidine, kamaline, (+)-N-carboxamidostepharine, (-)-O-methylstepharinosine, (-)-stepharinosine, aporphine (-)-O-acethylsukhodiamine and oxostephanosine. The chemical and biological investigations of this plant are interesting to bioassay-guided fractionation, particularly Antiproliferative … …American Journal of Applied Sciences, Vol. 7, Issue 8 · 31 Aug 2010 · 8,789 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleFoxp3-Mediated Immunity of Human Pancreatic Cancer Cell Line PANC-1Renxi Wang, Gencheng Han, Jianan Wang et al.Problem statement: More and more evidences have shown that human cancer cells can express Foxp3, the regulatory T cell-associated transcription factor. The role of Foxp3 in human cancer cells is still unclear. We detected Foxp3 expression in human pancreatic cancer cell line PANC-1. SiRNA assays showed that Foxp3 expression suppressed the expression of TGF-β and IL-10 which could induce immune … …American Journal of Immunology, Vol. 5, Issue 4 · 11 Jan 2010 · 7,363 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleRetinoids Chemosensitize Ovarian Cancer Cell Lines to Cisplatin Independent of Nuclear Receptors and p53Suresh Guruswamy, Doris M. BenbrookTreatment of ovarian cancer with cisplatin-based chemotherapy is highly toxic and is often followed by cancer recurrence. Repeated treatments with cisplatin frequently result in the development of resistance to this drug. Drugs with low toxicity that could enhance the tumor cell killing effects of cisplatin could potentially reduce the toxicity and enhance the efficacy of cisplatin. The mechanism of cell … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 6,958 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleThe Phenotypically Suppressed Cancer Cell As a Therapeutic TargetKimberly D. Kyker, Jessica E. Thorpe, Satyendra S. Shenoy et al.Bladder cancer recurs in up to 70% of patients judged to be tumor-free after treatment. Like other cancers, delayed appearance of metastases is common. These findings suggest the malignant phenotype can be suppressed, to emerge later. Following up on previous research in our laboratory showing that normal extracellular matrix can suppress the malignant phenotype of bladder cancers, we here demonstrate … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 6,471 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleInternalizing Versus Non-internalizing Receptors for Targeting L-Methioninase to Cancer CellsXiao-Ping Zang, Naveen R. Palwai, J. T. Pento, Roger G. HarrisonWe reported previously that L-methioninase targeted to the urokinase receptor of MCF-7 breast cancer cells is significantly more effective in inhibiting cell proliferation and migration than free L-methioninase both in vitro and in vivo. L-methioninase was targeted by linking at its amino terminus to an amino-terminal fragment (ATF) of urokinase. The ATF was selected for targeting because is has previously … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,817 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleRole of AP-1 Antagonism in Growth Inhibition of Cervical Cancer Cell Lines by RetinoidsShennan Lu, Doris M. BenbrookRetinoid compounds induce multiple molecular effects that need to be taken into consideration in the development of theses agents as pharmaceuticals for cancer chemoprevention. Inhibition of cancer cell growth by retinoids is thought to occur through at least two mechanisms of transcriptional regulation resulting from direct binding of retinoids to nuclear retinoid receptors (RARs and RXR’s). First, the nuclear receptors … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,477 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleHematologic Cancer Cell Detection and Classification Using Optimized VGG-19 with Stratified K-fold Cross-ValidationHema Patel, Himal Shah, Gayatri Patel, Atul PatelThe most prevalent pediatric blood malignancy is acute lymphoblastic leukemia (ALL). ALL is a lethal disease in which patients have a lower survival rate. Its prompt detection and precise categorization are essential for successful treatment. Manual microscopic diagnosis is laborious, prone to mistakes, and heavily reliant on specialized knowledge. With stratified 7-fold cross-validation, which assures an equal ratio of normal … …Journal of Computer Science, Vol. 21, Issue 11 · 24 Dec 2025 · 1,812 accessesView PDF Cite

Research NotesOpen accessPhrase in the titleAnalyses of the Interleukin32 Transcript Variants in Breast Cancer Cell LinesKayla Burrell, Audrey PlayerRecent data show the IL32 gene has at least nine transcript variants. The aim of this current study is to characterize the different transcript variants based on the latest sequencing data deposited in the National Center for Biotechnology Information (NCBI) and determine which variants are responsible for the differential pattern of gene expression previously observed in MCF7 compared to MDA … …American Journal of Immunology, Vol. 12, Issue 4 · 31 Oct 2016 · 6,949 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleAN EXPERIMENTAL STUDY ON THE HEAT ENHANCEMENT AND THE BIO-HEAT TRANSFER USING GOLD MACRO ROD AND ULTRASOUND: A POTENTIAL ALTERNATIVE TO KILL CANCER CELLSC. Austerlitz, I. Gkigkitzis, D. Campos, I. HaranasWe have previously proposed a method of treating solid tumors with a combination of gold macro-rods irradiated with ultrasound. Macro particle sized rods offer a greater circumferential treatment area over nanoparticle options. Experimental studies were conducted to investigate the heat enhancement and the bio-heat transfer to breast chicken using gold macro rod and ultrasound. An ultrasound, other than a focused … …Physics International, Vol. 5, Issue 2 · 26 May 2014 · 7,520 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleIsolation and Identification of Oral Cancer Stem Cells (CSC) within Commercially Available Cell LinesRobert Chauncey, Kai Hatch, Toni Jilka et al.Previous studies have demonstrated some tumors develop or maintain a small sub-population of cells with stem cell-like properties. This Cancer Stem Cells (CSC) may exhibit differential properties that allow their escape from traditional radiation or chemotherapy treatments and may therefore be responsible for cancer recurrence. Few studies have explored this phenomenon among oral cancer cell lines, therefore the objective of … …Current Research in Dentistry, Vol. 9, Issue 1 · 2 Jun 2018 · 12,719 accessesView PDF Cite