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18 results for “Affinity Analysis”
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Research ArticleOpen accessIn the abstractIN SILICO DESIGN OF THE M2 PROTON CHANNEL INHIBITORS OF H1N1 VIRUSUsman Sumo Friend Tambunan, Mochamad Reza Rahdiansyah, Arli Aditya ParikesitM2 proton channel of H1N1 Influenza A virus is the target protein anti-flu drugs amantadine and rimantadine. However, the two once powerful adamantane-based drugs lost their 90% bioactivity because of mutations of virus in recent twenty years. The resistance of influenza A virus to amantadine need to develop more effective adamantane-based drugs. Several research by molecular docking method have been … …OnLine Journal of Biological Sciences, Vol. 13, Issue 1 · 5 Jan 2013 · 7,999 accessesView PDFCite
Research ArticleOpen accessIn the abstractModulation of the GABAA Receptor by Srif in Rat ThalamusFatiha Chigr, Mariama El Ouahli, Ghizlane Er-Raoui et al.Somatostatin has been reported to modulate GABAA receptor complex in many brain structures. This study was conducted to investigate somatostatin modulation of the GABAA receptor binding in several rat diencephalic structures, focusing primarily on the thalamus, as this structure plays important roles. Animals were assigned to control conditions. Changes in specific binding of GABAA receptor as labelled with [35S]t-Butylbicyclophosphorothionate (TBPS) … …Neuroscience International, Vol. 3, Issue 2 · 14 Sep 2012 · 6,963 accessesView PDFCite
Research ArticleOpen accessIn the abstractInheritance based Intelligent Technique Employing Nested-XOR with Recursion for Recognition and Classification of Odors using Multi-Sensor Nose SystemMahmoud Z. IskandaraniProblem statement: Odor originality and fraud is an important issue in today’s world. In addition knowing the original material that an odor belongs to even after being mixed with others is also of vital importance. In addition measuring quality of mixed odors in terms of their affinity and belonging to a specific category or is critical. Approach: Design, testing and … …American Journal of Applied Sciences, Vol. 8, Issue 9 · 2 Aug 2011 · 6,676 accessesView PDFCite
Research ArticleOpen accessIn the abstractCharacteristic Study of the Marine Algae Sargassum sp. on Metal AdsorptionA. Saravanan, V. Brindha, Soundarajan KrishnanProblem statement: Biomass of brown marine macro algae is a biological resource that is available in large quantities and can form a good base for the development of biosorbent material. Approach: Algae have been found to be potentially suitable biosorbents because of its cheap availability, both in fresh or salt water, relatively high surface area and high binding affinity. Results: … …American Journal of Applied Sciences, Vol. 8, Issue 7 · 24 Jun 2011 · 7,660 accessesView PDFCite
Research ArticleOpen accessIn the abstractPurification of A Recombinant Thrombin-like Enzyme, Gloshedobin by Egg Yolk Antibody-Coupled AdsorbentsQing Yang, Xuyu Lei, Jianqiang Xu, Lijia AnThe gloshedobin, a snake venom thrombin-like enzyme was biosynthesized in the soluble form and purified by egg yolk antibody-coupled adsorbents from E. coli. As His-tag is not favored from the point of view of high-level and soluble expression, we herein constructed a recombinant gloshedobin without His-tag and developed a novel egg yolk antibody (IgY)-immunoaffinity chromatography for its purification in a … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,690 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordUPLC-Q-Exactive Orbitrap-MS Analysis of Anchusa italica Retz. Flowers: Molecular Docking, Dynamics Modeling, and Pharmacokinetics for Cardiovascular DiseaseLinyang Wang, Yan Chen, Ainiwaer Aikemu, Shuge TianThis study builds on prior UPLC-Q-Exactive Orbit rap-MS analyses of Anchusa italica Retz. Flowers (Airfs) to explore their anti-cardiovascular mechanis·ms and key bioactive markers. UPLC-Q-Exactive Orbitrap-MS identified 30 major compounds, including polyphenols and flavonoids with strong antioxidant activity. The potential active ingredients were then screened using Lipinski's rule of five, and a network pharmacology method was employed to construct an … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 25 Oct 2025 · 2,599 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordStructural and Substrate Interaction Properties of Alkaline Phosphatase from Paenibacillus sp. PSB04: In-Silico AnalysisHerman Umbau Lindang, Cahyo BudimanA Phosphate-Solubilising Bacterium (PSB) of Paenibacillus sp. PSB04 was previously isolated from the Sabah tropical rainforest in Malaysia. Interestingly, the genome sequence of the PSB04 strain harbored an Alkaline Phosphatase (AP) (EC 3.1.3.1) gene and was hypothesized to have unique structural characteristics. Therefore, this study aims to determine the AP three-Dimensional (3D) model and catalytic mechanism from Paenibacillus sp. PSB04 … …OnLine Journal of Biological Sciences, Vol. 22, Issue 3 · 16 Jul 2022 · 5,910 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordComparative Docking Analysis on Natural Compounds Versus a Synthetic Drug as a Therapeutic for Acquired Immuno Deficiency SyndromeSandhya R. Nair, R. Subhashini, B. ThiagarajanProblem statement: Acquired Immune Deficiency Syndrome (AIDS) is one of the worst pandemics affecting and spreading quickly all over the world with a high mortality rate. AIDS has been able to kill so many people due to the unique property of Human Immunodeficiency Virus (HIV) virus. It attacks the immune system of the victim there by not allowing the immune … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,323 accessesView PDFCite