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51 articles for “2A protease”
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Research ArticleOpen accessEvery word in the titleA Putative Serine protease from Larval Midgut of Red Palm Weevil Rhynchophorus ferrugineus (Olivier) (Coleoptera: Curculionidae): Partial Purification and Biochemical CharacterizationAhmed Al Jabr, Mahmoud Abo-El-SaadA putative serine protease was isolated and partially purified from larval midgut of red palm weevil (RPW), Rhynchophorus ferrugineus (Olivier) using anion exchange chromatography, DE-52. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of this protease showed that the major band has a molecular weight of approximately 24 kDa corresponding to the same molecular weight of mammalian trypsin. In addition, zymography … …American Journal of Environmental Sciences, Vol. 4, Issue 6 · 31 Dec 2008 · 7,018 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNovel Metal Accumulator and Protease Secretor Microbes from East Calcutta WetlandSanhita Chowdhury, Madhusmita Mishra, V.K. Adarsh et al.Nine bacterial isolates were screened from different sites of East Calcutta Wetland, an ecosystem located at the eastern fringes of Calcutta. Other than being a biodiversity rich area, the important feature of this system is that it is a natural sewage treatment plant for the city of Calcutta. In addition to daily sewage including solid and soluble wastes, a considerable … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 3 · 30 Sep 2008 · 8,987 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHIV-1-Specific CTL Recognizing a Scarce Epitope Are Not Suppressed by HIV-1 Protease InhibitorsOtto O. YangHIV-1-protease inhibitors have received growing attention as agents that can affect proteases in human proteasomes, with potentially deleterious effects for HIV-1-specific cellular immunity. Studying the antiviral activity of HIV-1-specific CTL that recognize an epitope that is presented at limiting concentrations on infected cells, we find that several HIV-1 protease inhibitors do not affect their function. These data indicate that these … …American Journal of Immunology, Vol. 3, Issue 1 · 30 Jun 2007 · 7,016 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMetabolic Abnormalities Associated with the Use of Protease Inhibitors and Non-nucleoside Reverse Transcriptase InhibitorsMadhu N. Rao, Grace A. Lee, Carl GrunfeldThe use of protease inhibitors and non-nucleoside reverse transcriptase inhibitors for the treatment of HIV infection and AIDS has been associated with multiple abnormalities in glucose and lipid metabolism. Specifically, these abnormalities include insulin resistance, increased triglycerides and increased LDL cholesterol levels. The metabolic disturbances are due to a combination of factors, including the direct effect of medications, restoration to … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,936 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Proteases on Meltability and Stretchability of Nabulsi CheeseKhaled Abu-Alruz, Ayman Suliman Mazahreh, Jihad M. Quasem et al.Problem statement: Boiled white brined cheese (Nabulsi cheese) is the mostly consumed cheese in Jordan; this cheese should show meltability and high stretchability in order to fit in the production of high quality Kunafa and other popular local sweets and pastries. However, these characteristics are rarely available when usual processing and preservation methods were used. Approach: This study was based … …American Journal of Agricultural and Biological Sciences, Vol. 4, Issue 3 · 30 Sep 2009 · 8,830 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEfficacy of Pravastatin in Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) and Protease Inhibitor (PI)-based HAART in HIV-Infected PatientsSusan A. Eaton, Anita P. Rahman, Sean T. Nguyen et al.Pravastatin has generally been considered a safe and effective option for HIV-infected patients on highly active antiretroviral therapy (HAART). However, pravastatin concentrations are known to significantly decrease with concomitant efavirenz (EFV) use. Currently there are no studies determining if these reductions in pravastatin possibly translate into an attenuation of its lipid lowering efficacy when used in HIV-infected patients on non-nucleoside … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,959 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIsolation and Characterization of Novel Metal Accumulating Extracellular Protease Secreting Bacteria from Marine Coastal Region of Digha in West Bengal, IndiaSusmita Roy, Kaushal Mishra, Sanhita Chowdhury et al.Problem statement: The objective of the present piece of work was to explore the existing biodiversity of protease secreting microbes in a marine ecosystem, the site selected being the coastal region of West Bengal (Digha), India. Approach: The culture dependent method was used for isolation and characterization of novel microbes from the point of biotechnological application. The isolate obtained was … …OnLine Journal of Biological Sciences, Vol. 8, Issue 1 · 31 Mar 2008 · 7,187 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleA Review: Biodegradation and Applications of Keratin Degrading Microorganisms and Keratinolytic Enzymes, Focusing on Thermophiles and Thermostable Serine ProteasesWirojne Kanoksilapatham, Weeranut IntagunKeratins are hard-degrading fibrous proteins, insoluble in water and organic solvents, often accumulated in nature and major components in feathers, skins, hair, horn, nail, hoof etc., Keratin-degrading microorganisms such as bacteria, archaea, actinomycetes and fungi employ keratinases to attack keratin. Keratinases belonging to subtilisin-like serine proteases were classified based on similarity of amino acid sequences. Keratinolytic thermophilic or hyperthermophilic bacteria … …American Journal of Applied Sciences, Vol. 14, Issue 11 · 10 Nov 2017 · 9,981 accessesView PDFCite
Research ArticleOpen accessIn the keywordsA Novel Industrially Promising Keratinase Isolated from Aspergillus aureolatus Changes its Substrate Specificity after pH-Mediated AutolysisArina Mokhova, Anna ShestakovaMicrobial proteolytic enzymes are green catalysts with many potential applications. Keratinolytic enzymes (or keratinases) are crucial for efficient keratin degradation, making them essential in waste management, biomedicine, cosmetics, and various industrial applications. This study describes the production and characterization of a protease with keratinolytic activity from Aspergillus aureolatus. The protease was isolated from the culture fluid on the 5th day … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 1 · 14 Feb 2025 · 5,580 accessesView PDFCite
Research ArticleOpen accessIn the keywordsOptimization of Enzymatic Hydrolysis of Freeze-Dried Sea Cucumber Powder with Response Surface Methodology and Its Antioxidant EvaluationYahui Pang, Jianfeng Sun, Qian LiuIn this study, freeze-dried sea cucumber powder was used as raw material and the preparation processing conditions were studied for hydrolysis of sea cucumber powder with neutral protease using Response Surface Methodology (RSM) to obtain a high concentration of sea cucumber polypeptide. The effects of hydrolysis temperature, pH, enzyme dosage and hydrolysis time on the degree of hydrolysis (DH) were … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 4 · 17 Oct 2016 · 7,431 accessesView PDFCite