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206 articles for “hypothesis”
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Research ArticleOpen accessIn the abstracttNOX (ENOX2) Target for Chemosensitization-Low-Dose Responses in the Hormetic Concentration RangeD. James Morre, Sara Dick, Elena Bosneaga et al.An emerging concept of cancer chemotherapy is that of chemosensitization. Most often applied to the treatment of drug-resistance cancers, chemosensitization has utility when such cancers are rendered drug sensitive through treatment with the sensitizing agent. A particularly striking example of chemosensitization is that encountered with the synthetic isoflavene phenoxodiol where patients with taxane- and/or platinum-resistant ovarian carcinoma once again become … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,568 accessesView PDFCite
Research ArticleOpen accessIn the abstractEpitope Mapping of Dengue-Virus-Enhancing Monoclonal-Antibody Using Phage Display Peptide LibraryChung-I Rai, Huan-Yao Lei, Yee-Shin Lin et al.The Antibody-Dependent Enhancement (ADE) hypothesis has been proposed to explain why more severe manifestations of Dengue Hemorrhagic Fever and Dengue Shock Syndrome (DHF/DSS) occur predominantly during secondary infections of Dengue Virus (DV) with different serotypes. However, the epitopes recognized by these enhancing antibodies are unclear. Recently, antipre-M monoclonal antibody (mAb 70-21), which recognized all DV serotypes without neutralizing activity, were … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 8,453 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunopathogenesis of Dengue Hemorrhagic FeverHuan-Yao Lei, Kao-Jean Huang, Yee-Shin Lin et al.Dengue virus infection causes Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) whose pathogeneses were not clearly understood. A new hypothesis of immunopathogenesis is proposed for the development of the DHF/DSS. An aberrant immune over-activation after dengue virus infection not only impair the immune response to clear the virus, but also result in overproduction of cytokines … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 14,762 accessesView PDFCite
Research ArticleOpen accessIn the abstractInfluence of Helium-Neon Laser Photostimulation on Excision Wound Healing in Wistar RatsB. S. Nayak, A. Maiya, P. KumarThe importance of laser photostimulation is now accepted generally but the laser light facilitates wound healing and tissue repair remains poorly understood. So we have examined the hypothesis that the laser photo stimulation can enhances the collagen production in excision wounds using excision wound model in Wister rat model. The circular wounds were created on the dorsum of the back … …OnLine Journal of Biological Sciences, Vol. 7, Issue 2 · 31 Dec 2007 · 7,376 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigating the Causality Granger Relationship between the Rates of Interest and Inflation in IranMansour Zarra Nezhad, Ruhollah ZareaWith regard to the importance of the rates of interest and inflation in economy, this paper aims at investigating the Granger causality relationship between the rates of interest and inflation in Iran’s economy. Toda and Yamamoto’s Granger test of causality as well as ARDL approach were used to test the hypothesis that the rate of interest is the Granger cause … …Journal of Social Sciences, Vol. 3, Issue 4 · 31 Dec 2007 · 7,696 accessesView PDFCite
Research ArticleOpen accessIn the abstractAdaptive Resonance Theory 1 (ART1) Neural Network Based Horizontal and Vertical Classification of 0-9 Digits RecognitionMbaitiga ZacharieThis study describes the Adaptive Resonance Theory 1 (ART1), an efficient algorithm that emulates the self-organizing pattern recognition and hypothesis testing properties of the ART neural network architecture for horizontal and vertical classification of 0-9 digits recognition. In our approach the ART1 model can self-organize in real time producing stable and clear recognition while getting input patterns beyond those originally … …Journal of Computer Science, Vol. 3, Issue 11 · 30 Nov 2007 · 7,346 accessesView PDFCite
Research ArticleOpen accessIn the abstractAccumulation of Cholesterol Esters in ex vivo Lymphocytes from Scrapie-susceptible Sheep and in Scrapie-infected Mouse Neuroblastoma Cell LinesAlessandra Pani, Claudia Norfo, Claudia Abete et al.Our studies on the role of cholesterol homeostasis in the pathogenesis of scrapie in sheep, revealed abnormal accumulation of cholesterol esters in brains and in ex vivo skin fibroblasts from genetically scrapie-susceptible, as compared to sheep with resistant genotype. We now report that PBMCs isolated from scrapie-susceptible sheep, as well as mouse neuroblastoma cell lines persistently infected with two different … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 6,955 accessesView PDFCite
Research ArticleOpen accessIn the abstractAttenuated Superoxide Dismutase Induction in Retinal Cells in Response to Intermittent High Versus Continuous High GlucoseMichael A. Ihnat, Ronald C. Kaltreider, Jessica E. Thorpe et al.High glucose, particularly in oscillating conditions, produces an increase in oxidative stress and has been shown to result in an increase in diabetic complications, retinopathy in particular. The hypothesis of this work was that chronic exposure to intermittent high glucose results in an attenuated induction of an antioxidant response as compared to continuous high glucose exposure in isolated retinal cells … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 1 · 31 Mar 2007 · 7,453 accessesView PDFCite
Research ArticleOpen accessIn the abstractExploring Strategies for Parallel Computing of RS Data Assimilation with SWAP-GAShamim Akhter, Kiyoshi Honda, Yann Chemin, Putchong UthayopasAn agro-hydrological simulation model is useful for agriculture monitoring. One issue in running such model is parameter identification, especially when the target area is large such as provincial or country level. Remote Sensing (RS) provides us with useful information over large area. RS cannot observe input parameters of agro-hydrological models directly. However, a method to estimate input parameters of such … …Journal of Computer Science, Vol. 3, Issue 1 · 31 Jan 2007 · 7,209 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunological Evidence for Peptide-Carbohydrate Mimicry with a Group A Streptococcus Polysaccharide-Mimetic PeptideSilvia Borrelli, Rehana B. Hossany, Susan Findlay, B. Mario PintoThe immunogenicity of a peptide-protein conjugate developed by linking a peptide mimic DRPVPY of the Group A Streptococcus cell-wall polysaccharide (GAS-CWPS), to tetanus toxoid (TT) was examined. BALB/c mice were immunized three times subcutaneously following homologous or heterologous prime/boost strategies at 4- or 6- week intervals in two different experiments. DRPVPY-TT, CWPS-TT, heat-killed, pepsin-treated GAS bacteria (with exposed polysaccharide) and … …American Journal of Immunology, Vol. 2, Issue 4 · 31 Dec 2006 · 6,956 accessesView PDFCite