Sign inSubmit
Tips: “quotes” for a phrase · author:Lee · a DOI goes straight to its article

228 articles for “Brain”
Set a search alert
Research ArticleOpen accessIn the abstractAMINO ACID TRANSPORTERS IN DRUG DISCOVERYMariafrancesca Scalise, Lorena Pochini, Michele Galluccio, Cesare IndiveriAdministered drugs interact with membrane transporters of epithelia, Blood Brain Barrier and other districts influencing their delivery and efficacy. Drugs can also be used as inhibitors of transporters involved in human pathology. Drug-transporter interactions are responsible of off-target effects contributing to toxicity. High Throughput Screening technologies increased the potential applications in therapy or in predicting side effects. These strategies will … …Current Research in Drug Discovery, Vol. 1, Issue 1 · 2 Oct 2014 · 7,101 accessesView PDFCite
Research ArticleOpen accessIn the abstractEXERCISE TRAINING REVERSES THE DELETERIOUS EFFECT OF SUCROSE INTAKE ON INSULIN RESISTANCE AND VISCERAL FAT MASS DEPOSITION ON MICEJulio Cesar Mendes Soares, Vanderlei Folmer, Gustavo Puntel, João B.T. Da RochaAbnormal fat deposition has been identified as an important mechanism of obesity-associated with insulin resistance. Literature data also indicate that exercise can improve insulin action. The heme pathway enzyme δ-Aminolevulinate Dehydratase (δ-ALA-D) is a good marker for oxidative stress and this sulfhydryl enzyme is inhibited in such oxidative pathologies diabetes. The aim of this study was to evaluate the effects … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 1 · 28 Mar 2014 · 7,324 accessesView PDFCite
Research ArticleOpen accessIn the abstractHISTOPATHOLOGICAL CHANGES IN MICE INFECTED WITH RIVER WATER CONTAMINATED BY PASTEURELLA MULTOCIDA TYPE B:2Mohammed Muqdad Khaleel, Faez Firdaus Jesse Abdullah, Lawan Adamu et al.Haemorrhagic Septicaemia (HS) is a fatal systemic disease of bovines typified by an acute, highly fatal septicaemic disease with high morbidity and mortality. In this study, sixty five adult ICR mice were used for the study. In the first phase, 5 mice each were inoculated with 109 cfu of P. multocida type B:2 through the intraperitoneal route. After development of … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 2 · 28 Mar 2014 · 7,758 accessesView PDFCite
Research ArticleOpen accessIn the abstractSOFT COMPUTING APPROACH TO PREDICT INTRACRANIAL PRESSURE VALUESMario VersaciThe estimation and the prediction of the values related to the Intracranial Pression (ICP) represents an important step for the evaluation of the compliance of the human brain, above all in those cases in which the increase of the ICP values determines high risk conditions for the patient. The regular therapy is neuro-surgical but, waiting for it, it is needed … …American Journal of Applied Sciences, Vol. 11, Issue 5 · 7 Mar 2014 · 6,680 accessesView PDFCite
Research ArticleOpen accessIn the abstractCHRONIC NEONATAL DIAZOXIDE THERAPY IS NOT ASSOCIATED WITH ADVERSE EFFECTSMichele M. Cox, Christopher C. Wendler, Ildiko Erdelyi et al.Diazoxide is an ATP-sensitive potassium channel (KATP) agonist that has been shown to neuroprotective effects. These observations raise the possibility that diazoxide may have potential as a therapeutic agent for other applications. This study investigated (1) the long term effects of chronic neonatal administration of diazoxide and (2) the role of KATP on murin behavior and neurohistology. C57B/6J pups were … …OnLine Journal of Biological Sciences, Vol. 14, Issue 1 · 27 Jan 2014 · 7,452 accessesView PDFCite
Research ArticleOpen accessIn the abstractAPIGENIN CAUSES BIOCHEMICAL MODULATION, GLUT4 AND CD38 ALTERATIONS TO IMPROVE DIABETES AND TO PROTECT DAMAGES OF SOME VITAL ORGANS IN EXPERIMENTAL DIABETESChowdhury Mobaswar Hossain, Miltu Kumar Ghosh, Bhabani Sankar Satapathy et al.Diabetes mellitus gradually leads to dysfunction and failure of some vital organs specially the eyes, kidneys, pancreas, brain, heart, liver and lungs. The study was aimed to evaluate the antidiabetic potential of apigenin and its mechanistic role in controlling damages of vital tissues in streptozotocin-induced diabetic rats. Streptozotocin-induced diabetic rats were treated with apigenin and glipizide. Various biochemical changes, GLUT4 … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 13 Jan 2014 · 15,680 accessesView PDFCite
Research ArticleOpen accessIn the abstractRnai Induced Wing Modification in Leon Mutant Drosophila: A Developmental AnalysisSandeep Satapathy, Cheng Ting ChienThe precision of growth of an animal is meticulously regulated by extrinsic and intrinsic factors, with focus on maintenance of organismal homeostasis. The clue to change in physiology or metabolism of an organism, at times can be derived from the changes in phenotypes. In the Drosophila melanogaster model system, GAL 4-overexpressed RNAi driver males (Mini-White Marker), targeted against specific genes, … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 4 · 20 Dec 2013 · 6,719 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Bisphenol a on Passive Avoidance Performance in Male RatsMahnaz Taherianfard, Bita Geramizadeh, Mehrzad Banihashemi et al.Bisphenol A (BPA) is used to manufacture polycarbonate plastic products in resins lining metal cans, in dental sealants and in blends with other types of plastic products. In sharp contrast, there are many published studies that BPA has a wide range of significant adverse effects including structural and neurochemical changes throughout the brain associated with behavioral changes, such as hyperactivity, … …Current Research in Medicine, Vol. 4, Issue 2 · 10 Dec 2013 · 7,225 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntiretroviral Toxicity and Oxidative StressAdikwu Elias, Brambaifa Nelson, Deo Oputiri, Oru-Bo Precious GeoffreyAntiretroviral drugs are used for the treatment of human immunodeficiency virus, they are used as combination regimens to achieve the highest possible benefit, tolerability, compliance and to diminish the risk of resistance development. Reports from preclinical and clinical studies have linked antiretrovirals with some toxicological effects which could be associated with redox imbalance (oxidative stress). This stimulated us to review … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 20 Nov 2013 · 8,260 accessesView PDFCite
Research ArticleOpen accessIn the abstractGENETIC ALGORITHM AND NEURAL NETWORK FOR OPTICAL CHARACTER RECOGNITIONHendy Yeremia, Niko Adrianus Yuwono, Pius Raymond, Widodo BudihartoComputer system has been able to recognize writing as human brain does. The method mostly used for character recognition is the backpropagation network. Backpropagation network has been known for its accuracy because it allows itself to learn and improving itself thus it can achieve higher accuracy. On the other hand, backpropagation was less to be used because of its time … …Journal of Computer Science, Vol. 9, Issue 11 · 19 Sep 2013 · 7,650 accessesView PDFCite