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192 results for “Pathway”
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Research ArticleOpen accessIn the abstractREMEDIAL EFFECTS OF VITAMIN E AND L-ARGININE ON PERIPHERAL NEUROPATHY IN STREPTOZOTOCIN-INDUCED DIABETIC RATSIsmaeel Bin-Jaliah, Samah El-Attar, Eman F. Khaleel et al.It was shown that hyperglycemia in diabetic patients is the main factor of diabetic peripheral neuropathies. Various pathways related to oxidative stress, vascular defect and defective endothelium dependent relaxation have been implicated in the development of diabetic peripheral neuropathy. A substantial number of studies have shown that antioxidant treatment are promising therapeutics that can prevent or correct reduced motor nerve … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 23 Dec 2013 · 8,044 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Gc-Macrophage Activating Factor in Human Neurons; Implications for Treatment of Chronic Fatigue SyndromeRodney Smith, Lynda Thyer, Emma Ward et al.Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease of multifactorial aetiology characterized by immune system dysfunction, widespread inflammation, multisystemic neuropathology and persistent pain. Given the central role of the immune system in the pathogenesis of the syndrome, we studied the effects of a potent modulator of the immune system in in vitro and in vivo models that could help … …American Journal of Immunology, Vol. 9, Issue 4 · 6 Nov 2013 · 10,991 accessesView PDFCite
Research ArticleOpen accessIn the abstractHYPOXIC INFLAMMATION, A DEADLY BRIDGE TO MALIGNANT TRANSFORMATION AND A FERTILE SOIL FOR CANCER PREVENTIONKambiz Afrasiabi, Robert Edwards, Jonathan Melekh-Shalom, Kehui WangThe interplay of the inflammatory microenvironment with its hypoxic niche and the potential mechanism by which they lead to malignant transformation has long been the subject of great controversy and continues to be an area of great interest today. In our previous studies we have examined this subject by using Gia2 knock out mice as the focus of our research. … …OnLine Journal of Biological Sciences, Vol. 13, Issue 3 · 4 Sep 2013 · 7,149 accessesView PDFCite
Research ArticleOpen accessIn the abstractDetermination and Source Apportionment of Selected Heavy Metals in Aerosol Samples Collected from SebeleAlfred Sello Likuku, Gilbert Kabelo Gaboutloeloe, Khumoetsile B. MmolawaBush fires and dust in the dry winter months establish moderately high background levels of aerosols. Emissions into the atmosphere by copper mines, coal mines and vehicular emissions are all possible sources of air pollution with heavy metals. Although there has been assessment and monitoring of heavy metals and their air pollution in other countries such as Brazil, Europe and … …American Journal of Environmental Sciences, Vol. 9, Issue 2 · 25 Apr 2013 · 7,446 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn-Depth Review of Human Immunodeficiency Virus-Associated NephropathySira Korpaisarn, Wisit Cheungpasitporn, Daych Chongnarungsin et al.Human Immunodeficiency Virus (HIV)-Associated Nephropathy (HIVAN) is one of the most important renal complications found in HIV-infected individuals. Morbidity and mortality in this group of patients increases due to End-Stage Renal Disease (ESRD). Classic histological characteristics of HIVAN are collapsing Focal Segmental Glomerulosclerosis (FSGS), microcystic tubular dilation and interstitial inflammation and fibrosis. High prevalence of HIVAN among people of African … …Current Research in Medicine, Vol. 4, Issue 1 · 19 Apr 2013 · 7,366 accessesView PDFCite
Research ArticleOpen accessIn the abstractRestoration of Biodiversity and EcosystemIgnacio Santa-Regina, M. C. Santa-ReginaSuccession is one of the most studied processes in ecology and succession theory provides strong predictability. However, few attempts have been made to influence the course of succession thereby testing the hypothesis that the passage of one stage is essential to enter a next one. At each stage of succession ecosystem processes may be affected by the diversity of species … …American Journal of Engineering and Applied Sciences, Vol. 6, Issue 1 · 10 Mar 2013 · 6,989 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Innate Immunity in Bovine Mastitis: The Role of Pattern-Recognition ReceptorsFernando Nogueira de Souza, Eduardo Milton Ramos Sanchez, Marcos Bryan Heinemann et al.Mastitis is the most costly disease for dairy farmers and industry, which are mainly caused by the entry of bacteria to the teat canal. Shortly after the entry of the invading bacteria, the innate immunity recognizes the invading pathogen through pattern recognition receptors and initiates the inflammatory response necessary to eliminate the invading bacteria. This initial inflammatory response releases cytokines … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Oct 2012 · 10,357 accessesView PDFCite
Research ArticleOpen accessIn the abstractEnumeration of Microbes and Gas Production During Denitrification and Nitrogen Fixation Processes in SoilA. E. Ghaly, K. N. MacDonaldDry plant material contains 2-4% nitrogen, making it an essential nutrient for all plants. The nitrogen cycle regulates the pathways which transform nitrogen from a relatively inert dinitrogen gas to forms of organic nitrogen such as proteins and nucleic acids. Denitrification and nitrogen fixation are the two most important processes that remove and add nitrogen to the soil, respectively. The … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 3 · 11 Sep 2012 · 8,622 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Inflammation in Development and Therapy of Malignant MesotheliomaArti Shukla, Jill MillerMalignant Mesothelioma (MM) is an asbestos related malignancy with a poor prognosis and limited therapeutic approaches. The pathogenesis of MM has been linked to asbestos induced inflammation. Asbestos exposure results in reactive oxygen species generation, infiltration of inflammatory cells and prolonged release of multiple cytokines, oxidants and growth factors. The role of inflammation in MM has led to the evaluation … …Current Research in Medicine, Vol. 3, Issue 2 · 30 Aug 2012 · 7,439 accessesView PDFCite
Research ArticleOpen accessIn the abstractBayesian Exploration of Multilocus Interactions on the Genome-Wide ScaleIvan Kozyryev, Jing ZhangProblem statement: Recent technological and scientific advances propelled the field of Genome-Wide Association Study (GWAS), which promises to be instrumental in linking many common complex diseases to their genetic origin. While so far such large-scale surveys have been moderately successful in identifying disease related genetic variants, much of disease heritability is still not accounted for by the discovered loci. There … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 2 Jul 2012 · 7,410 accessesView PDFCite