137 results for “immune system”

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Research ArticleOpen accessIn the abstractMicrobial Translocation and B Cell Dysfunction in Human Immunodeficiency Virus DiseaseWei JiangThe gut mucosal barrier disrupted in HIV disease, resulting in increased systemic exposure to microbial products such as Lipo Polys Accharide (LPS). The association of enhanced microbial translocation and B cell dysfunction in HIV disease is not fully understood. High dose and short term exposure of microbial Toll-Like Receptor (TLR) agonists were used as vaccine adjuvants, however, low dose and … …American Journal of Immunology, Vol. 8, Issue 2 · 30 Jun 2012 · 7,409 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRole of IL-10 in Urinary Bladder Carcinoma and Bacillus Calmette-Guerin ImmunotherapyYi Luo, Eric J. Askeland, Mark R. Newton, Michael A. O’DonnellProblem statement: Bladder cancer is a common urologic cancer and intravesical Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is the mainstay in the treatment of superficial bladder cancer. However, the current BCG therapy is not desirable with respect to its efficacy and side effects. Interleukin (IL)-10, a T helper type (Th) 2 cytokine, plays an important regulatory role in bladder cancer immunosurveillance … …American Journal of Immunology, Vol. 8, Issue 1 · 9 Mar 2012 · 8,005 accessesView PDF Cite

Research ArticleOpen accessIn the abstractComparison of Bit Error Rate Performance of Multi Tone Channel Utilising De-OQPSK and De-Off Set 16 QAM with Guard IntervalIbrahim A.Z. QatawnehDigital communications systems use Multi tone Channel (MC) transmission techniques with differentially encoded and differentially coherent demodulation. Today there are two principle MC application, one is for the high speed digital subscriber loop and the other is for the broadcasting of digital audio and video signals. In this study the comparison of multi carriers with OQPSK and Offset 16 QAM … …Journal of Computer Science, Vol. 1, Issue 3 · 30 Sep 2005 · 6,847 accessesView PDF Cite

Review ArticleOpen accessAll words, across the recordJAK Inhibitors for Rheumatoid Arthritis: Assessing Efficacy and Safety in TreatmentAnastasia V. Poznyak, Varvara A Orekhova, Natalia Vladimirovna Elizova et al.Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, progressive joint destruction, and systemic complications. Dysregulated cytokine signaling through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a central role in RA pathogenesis, making JAK inhibitors an important therapeutic option. Tofacitinib, baricitinib, and upadacitinib are oral targeted synthetic disease-modifying antirheumatic drugs that interfere with … …OnLine Journal of Biological Sciences, Vol. 26, Issue 4 · 8 Oct 2026 · 412 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordMechanisms of Anti-Cancer Effects of Vernonia amygdalina Leaf ExtractUtoh-Nedosa Uchechukwu AnastasiaProblem statement: Vernonia amygdalina (V. amygdalina) has been shown to have cancer cell inhibition and cytotoxic effects. Approach: This study discusses the multi-faceted and multi-linked mechanisms by which cancer tissue inhibition and destruction is achieved by V. amygdalina leaf extract and powder (subsequently called V. amygdalina Extract). Cancer cell inhibition by V. amygdalina is suggested to occur through inhibition of … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 26 Oct 2011 · 9,090 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordFormulation and Evaluation of a Novel Needle-Free Hepatitis B Surface Antigen Delivery SystemC. D. Licy, K. Premalatha, Annie Shirwaikar, Arun ShirwaikarProblem statement: Hepatitis B is a major public health problem, killing 1-2 million people annually, despite the introduction of an effective vaccine in 1982. Approximately 400 million persons worldwide have chronic hepatitis B. This is due to problems associated with vaccine delivery, stability and cost. Hence the present challenge in Vaccinology is to develop safer, cheaper and easy-to-deliver forms of … …Current Research in Medicine, Vol. 1, Issue 2 · 30 Oct 2010 · 6,819 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordRetinoids and Opioids: Factors in the Development of HIV-Related Neurological DiseaseWalter Royal, III, Joseph L. BryantNeurological disease occurs frequently in HIV-infected individuals and may occur at even higher rates among infected drug users. Among the potential mechanisms that promote such impairment, retinoid deficiency may have selective effects that could both lead to alterations in immune function and enhanced replication of HIV. Studies are currently underway to examine the possible selective effects of retinoid receptor activation … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,764 accessesView PDF Cite