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146 articles for “Metabolism”
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Research ArticleOpen accessIn the abstractEvidence of Mitochondrial Dysfunction in Autism and Implications for TreatmentDaniel A. Rossignol, J. Jeffrey BradstreetClassical mitochondrial diseases occur in a subset of individuals with autism and are usually caused by genetic anomalies or mitochondrial respiratory pathway deficits. However, in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe signs and symptoms. … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 16,389 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Novel Rodent Model of Autism: Intraventricular Infusions of Propionic Acid Increase Locomotor Activity and Induce Neuroinflammation and Oxidative Stress in Discrete Regions of Adult Rat BrainDerrick F. MacFabe, Karina Rodríguez-Capote, Jennifer E. Hoffman et al.Innate neuroinflammatory changes, increased oxidative stress and disorders of glutathione metabolism may be involved in the pathophysiology of autism spectrum disorders (ASD). Propionic acid (PPA) is a dietary and gut bacterial short chain fatty acid which can produce brain and behavioral changes reminiscent of ASD following intraventricular infusion in rats. Adult Long-Evans rats were given intraventricular infusions of either PPA … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 12,618 accessesView PDFCite
Research ArticleOpen accessIn the abstractLipid Profile of Gymnasts of the Jordan National TeamAhmad Bani Ata, Kamal Mansi, Talal AburjaiThis study was carried out to assess the lipid pattern in gymnasts of the Jordan National Team. Twelve athletes represent the National gymnastic team (4 males and 8 females, mean age 18±1 year) were included in this study. The training period for them is not less eight years during which they trained 18 hours weekly at least. A group of … …American Journal of Applied Sciences, Vol. 5, Issue 6 · 30 Jun 2008 · 7,536 accessesView PDFCite
Research ArticleOpen accessIn the abstractHeat Balance Analysis During the Production of Jadomycin CT. J. Burdock, A. H. Giffin, M.S. Brooks, A.E. GhalyJadomycins are novel antibiotics that exhibit biological activity against bacteria and yeast and also demonstrate cytotoxicity against cancer cells. Jadomycin C was successfully produced from 10 L of fermentation media in a 19 L bioreactor using Streptomyces venezuelae ISP5230 which was shocked with ethanol. The bioreactor temperature and pH were successfully maintained at 30°C and 7, respectively. The heat of … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 1 · 31 Mar 2008 · 7,715 accessesView PDFCite
Research ArticleOpen accessIn the abstractMicroarray Analysis of Human Vascular Smooth Muscle Cell Responses to Bacterial LipopolysaccharideJoe Minta James, J. Yun, Sandy Der, Shikha RanaAccumulating evidence suggest a causal role of bacterial and viral infections in atherogenesis. Bacterial lipopolysaccharide (LPS) has been shown to stimulate resting vascular smooth muscle cells (SMC) with the production of inflammatory cytokines and modulation of quiescent cells to the proliferative and synthetic phenotype. To comprehensively identify biologically important genes associated with LPS-induced SMC phenotype modulation, we compared the transcriptomes … …American Journal of Immunology, Vol. 3, Issue 2 · 31 Dec 2007 · 6,998 accessesView PDFCite
Research ArticleOpen accessIn the abstractBioaccumulation of Cr(III) ions by Blue Green-alga Spirulina sp. Part II. Mathematical ModelingKatarzyna Chojnacka, Piotr M. WojciechowskiIn the present paper bioaccumulation of Cr(III) ions by blue-green algae Spirulina sp. is discussed. We found that the process consisted of two stages: passive in which Cr(III) ions are bound to the surface of cells, identical with biosorption and active, metabolism-dependent, in which Cr(III) ions are transported into the cellular interior. The passive stage occurs in both living and … …American Journal of Agricultural and Biological Sciences, Vol. 2, Issue 4 · 31 Dec 2007 · 8,298 accessesView PDFCite
Research ArticleOpen accessIn the abstractAccumulation of Cholesterol Esters in ex vivo Lymphocytes from Scrapie-susceptible Sheep and in Scrapie-infected Mouse Neuroblastoma Cell LinesAlessandra Pani, Claudia Norfo, Claudia Abete et al.Our studies on the role of cholesterol homeostasis in the pathogenesis of scrapie in sheep, revealed abnormal accumulation of cholesterol esters in brains and in ex vivo skin fibroblasts from genetically scrapie-susceptible, as compared to sheep with resistant genotype. We now report that PBMCs isolated from scrapie-susceptible sheep, as well as mouse neuroblastoma cell lines persistently infected with two different … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 6,960 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of Cholesterol Esterification Influences Cytokine Exspression in Lypopolisaccharide-activated P388D1 MacrophagesRosa Rita Bonatesta, Francesca Sanna, Sabrina Uda et al.Several in vivo and in vitro studies have demonstrated the involvement of infectious agents in the development of atherosclerosis. However, the mechanisms by which micro-organisms induce and/or aggravate atherosclerosis, are so far unclear. Accumulation of cholesterol esters and lipid laden cell formation are hallmark of the atherogenesis, however, the possible relationship between cholesterol esterification and the signal-transducing component of LPS … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 7,484 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudy the Effects of Ramadan Fasting on the Serum Glucose and Lipid Profile among Healthy Jordanian StudentsKama Mohmoud Saleh MansiRamadan is the holiest month in the Islamic calendar and Muslims fast during this month. We designed this study to evaluate the effect of Ramadan fasting on plasma lipids profile and serum glucose among healthy Jordanian students. Ramadan fasting entails major changes in sleep pattern, physical activity and eating habits, which may cause changes in metabolism both in health and … …American Journal of Applied Sciences, Vol. 4, Issue 8 · 31 Aug 2007 · 8,466 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Proteolytic System of Candida dubliniensisLoaiza-Loeza Salomé, Parra-Ortega Berenice, Bautista-Muñoz Consuelo et al.Proteases of Candida dubliniensis have been scarcely studied, these enzymes may play an important role in nitrogen metabolism, post-translational processing, nutritional stress, dimorphism, virulence, etc. In this work, we report the presence of five different intracellular proteases and one extracellular proteolytic activity. The intracellular proteases are: aminopeptidase ycdAPE, carboxypeptidase ycdCP, dipeptidyl aminopeptidase ycdDAP, proteinases ycdPrA and ycdPrB, and extracellular protease … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 6,958 accessesView PDFCite