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Research ArticleOpen accessIn the abstractAnti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic ExtractMarslin Gregory, K. P. Vithalrao, G. Franklin, V. KalaichelavanProblem statement: In spite of being one of the well-known medicinal plants used in Indian traditional medicine to treat several ailments, studies pertaining to the pharmacological properties of Ficus arnottiana are very scarce. We studied the anti-ulcer activity and acute toxicity of Ficus arnottiana leaf methanolic extract for the first time. Approach: Freshly collected F. arnottiana leaves were dried, powdered … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 9,329 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn vivo, Acute, Normo-hypoglycemic, Antihyperglycemic, Insulinotropic Actions of Orally Administered Ethanol Extract of Citrullus colocynthis (L.) Schrab PulpMahmoud Al-Khateeb, Mohammad Dallak, Fahaid Al-Hashem et al.Problem statement: Citrullus colocynthis (L.) Schrab (cucurbitaceae family) (Handal) is a fruit commonly known as bitter apple or bitter cucumber. Traditionally, Citrullus colocynthis has been used for the treatment of diabetes. In particular, the acute effect and rout of administration of ethanol extract of the seedless pulp in vivo remains untested. We investigated the effect of different routs of administration … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 3 · 30 Sep 2009 · 8,306 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Flavonoid, Quercetin, Inhibits HIV-1 Infection in Normal Peripheral Blood Mononuclear CellsMadhavan P.N. Nair, Zainulabedin M. Saiyed, Nimisha H. Gandhi, C. N. RamchandProblem statement: Flavonoids and related polyphenols, have been known to possess cardioprotective, anti-tumor, anti-inflammatory, anti-allergic and anti-viral activities. Previous studies have shown that flavonoid, quercetin significantly downregulates expression of pro-inflammatory cytokines in cultured cells via modulation of NFκB and p38MAPK signaling pathways. In the current study, we hypothesize that quercetin exerts anti-HIV activity by differential modulation of pro-and anti-inflammatory cytokine … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 12,184 accessesView PDFCite
Research ArticleOpen accessIn the abstractRecent Trends in Ozone and Particle Concentrations in the Sydney (Australia) AirshedMerched Azzi, Hiep DucAn overview is presented of changes in ground level ozone and atmospheric fine particles determined using ambient monitoring data collected at selected locations in Sydney, Australia. After removing seasonally, auto-regressive and moving average dependence from the selected time series, the trend of a selected series was modelled using the fractional long-term dependent component. The selected technique was able to detect … …American Journal of Environmental Sciences, Vol. 4, Issue 5 · 31 Oct 2008 · 6,682 accessesView PDFCite
Research ArticleOpen accessIn the abstractMicrobial Biodiversity Screening for Metal Accumulators from Mineral Ore Rich Site in Andhra Pradesh, IndiaAditya Kumar Sarkar, Susmita Roy, Ananya Pal et al.Problem statement: Since the site selected for screening was a source of magnetite, the objective of this study was to isolate some groups of magnetotactic bacteria and microbes with potential of metal accumulation. Approach: The culture based approach was used for the study. Pure isolates obtained were characterized on the basis of morphology, biochemical tests, physiology as well as at … …OnLine Journal of Biological Sciences, Vol. 8, Issue 2 · 30 Jun 2008 · 7,546 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Mathematical Modeling Approach to Characterize Hormesis, Caloric Restriction and Toxicity in Mortality Data from Toxicity StudiesPatricia J. NeafseyThe mortality of a population reflects the combined effects of natural aging with environmental insults (e.g. toxicant exposure, caloric restriction, over feeding, infections, etc.). No single endpoint, such as carcinogenesis, completely describes toxicant-induced effects in laboratory animals. Mathematical models of mortality and time-dependent exposure to toxicants can yield indices of net injury from all causes. With careful manipulation of diet … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,160 accessesView PDFCite
Research ArticleOpen accessIn the abstractDengue Virus Infection Induced NF-κB-dependent Macrophage Migration Inhibitory Factor ProductionLien-Cheng Chen, Huey-Wen Shyu, Huan-Yao Lei et al.Dengue virus (DV) infection can cause mild dengue fever or severe dengue hemorrhage fever and dengue shock syndrome. Macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in the modulation of inflammatory and immune responses and serum levels of MIF are correlated with disease severity in dengue patients. However, the mechanism that induces MIF production during … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,290 accessesView PDFCite
Research ArticleOpen accessIn the abstractTactile Distinction of an Artery and a Tumor in a Soft Tissue by Finite Element MethodAli Abouei Mehrizi, Siamak Najarian, Majid Moini, Farhad Tabatabai GhomsheTactile detection of a tumor and an artery in a tissue and distinction of a healthy artery from a stenotic artery, using finite element method, are presented. Four 2D models of tissue have been created: tissue itself, tissue including a tumor (TIT), tissue including a healthy artery (TIHA), and tissue including a stenotic artery (TISA). After solving four models with … …American Journal of Applied Sciences, Vol. 5, Issue 2 · 28 Feb 2008 · 7,596 accessesView PDFCite
Research ArticleOpen accessIn the abstractMethamphetamine Inhibits β-Chemokines and Co-Stimulatory Molecule Expression by Dendritic CellsMadhavan P.N. Nair, Jose W. Rodriguez, Irina M. Borodowsky et al.The US is currently experiencing a serious epidemic of methamphetamine (Meth) use entangled with HIV-1 infection. Blood monocyte derived dendritic cells (DC ) are the first line of defense against HIV-1 infection and are the initial target of HIV-1 in injection drug users. Chemokines are known to be HIV-1 suppressing molecules and are positively associated with non- progression of HIV … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 6,543 accessesView PDFCite
Research ArticleOpen accessIn the abstractShed Skin of Ophiophagus hannah: Structural Topography and In Vitro Permeation of Nicotine and PhenolA. Priprem, T. Pongjanyakul, C. Khamlert et al.Scales of the dorsal portions of shed skin of king cobras (Ophiophagus hannah) was used as the barrier membrane for in vitro permeation of nicotine and phenol at toxic or irritable concentration levels. The scales were placed between solutions of nicotine or phenol in a donor solution at pH 5.6 and a receptor solution at pH 7.4. Cumulative amounts of … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 4 · 31 Dec 2007 · 6,735 accessesView PDFCite