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168 results for “HIV”
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Research ArticleOpen accessIn the abstractInnate, Adaptive and Intrinsic Immunity in Human Immunodeficiency Virus InfectionSuneth S. Perera, Nitin K. SaksenaThe first line of defence of the innate immune system functions by recognizing highly conserved sets of molecular structures specific to the microbes, termed pathogen-associated molecular patterns, or PAMPs via the germ line-encoded receptors Pattern-Recognition Receptors (PRRs). In addition to the innate immune system, the vertebrates have also evolved a second line of defence termed adaptive immune system, which uses … …American Journal of Infectious Diseases, Vol. 8, Issue 3 · 27 Nov 2012 · 9,727 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Novel Human Immunodeficiency Virus-1 Integrase Inhibitors by Shape-Based Virtual ScreeningT.K. Omprakash, A. Thamarai Selvan, A. Shahul Hameed, S.P. GeethaProblem statement: Human Immunodeficiency Virus-1 (HIV-1) is causative agent of the immune system disease, Acquired Immune Deficiency Syndrome (AIDS). Majority of anti-HIV drugs target reverse transcriptase and protease enzymes. Toxicity and development of multidrug resistant HIV-1 virus strains are the reasons for studying new targets in HIV-1 replication process for identifying novel inhibitor with low toxicity and high activity. Approach: … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Dec 2010 · 7,193 accessesView PDFCite
Research ArticleOpen accessIn the abstractHuman Immunodeficiency Virus and Carcinoma CervixA. Jaisri, Shanta Bhaskaran, Prasanna KumarProblem statement: Carcinoma of the cervix is the second leading cause of death in women in the world. Human Papilloma Virus (HPV) which plays a major role in the etiology of cervical cancer is said to have the same mode of transmission as the Human Immunodeficiency Virus (HIV). Hence the curiosity to learn the prevalence, incidence and association of cervical … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 6,581 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of Resistance to Human Immunodeficiency Virus Protease Inhibitors Using Molecular Mechanics and Machine Learning StrategiesA. Harishchander, D. Alex Anand, Sanjib SenapatiProblem statement: Drug resistance is the most important factor, which influences the failure of current HIV therapies. So, the ability to predict the drug resistance of HIV-1 protease mutants will be useful in developing more effective and longer lasting treatment regimens. Approach: Drug resistance of HIV-1 protease is predicted with two current protease inhibitors (Indinavir and Saquinavir). The problem was … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,206 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Cross-sectional Study of Sexual Practices, Sexually Transmitted Infections and Human Immunodeficiency Virus among Male-to-Female Transgender PeopleP.S. Saravanamurthy, P. Rajendran, Priya Maria Miranda et al.Problem statement: Designing HIV interventions requires evidence on links between behaviors and elevated transmission risk that remains scanty for male-to-female Transgender (TG) people in India. Approach: In 2007, we carried out a cross-sectional study through convenience sampling of 131 TG aged > 18years, residing in Chennai at least prior to six months of the study. Sexual practices and perception towards … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 8,373 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effects of Protease Inhibitors on Metabolic Complications and Lipodystrophy in Human Immunodeficiency Virus-Infected PatientsMohd Khaza, K. Laxmi Prasad, M. EstariProblem statement: Highly Active Antiretroviral Therapy (HAART)-associated metabolic complications include lipoatrophy (loss of Subcutaneous Adipose Tissue (SAT) and insulin resistance. The risk of Diabetes Mellitus (DM) in Human Immunodeficiency Virus (HIV)-infected patients receiving Highly Active Antiretroviral Therapy (HAART) especially protease inhibitors has not been well defined. Approach: We conducted an analysis in the Hospital of Rajeev Gandhi Institute of Medical … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 6,936 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of Hematological and Alternate Markers in Human Immunodeficiency Virus Disease ProgressionK. V. Ramana, Jagadeeshwara Chary, V. Sabitha et al.Problem statement: The knowledge of HIV infection has expanded tremendously which has led to significant improvement in the treatment, leading to decrease in morbidity and mortality. Considering the limitations in using CD4+T-cell counts and HIV RNA viral load as markers in the HIV disease progression, physicians treating the HIV patients now look for alternate markers that predict HIV disease progression … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,375 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparison of Tuberculin Skin Test and Interferon Gamma Assay for the Diagnosis Latent TuberculosisAbolfazl Poorhasan, Mehdi Haghdoost, Omid MashrabiProblem statement: After HIV infection, TB is the most common cause of mortality due to a single infectious agent. Until 1985, tuberculosis cases in the world were decreasing every year, but then with the prevalence of HIV infection, TB cases are increasing every year. Obviously, with this prevalence of tuberculosis, the best way to control it is to track the … …American Journal of Infectious Diseases, Vol. 6, Issue 2 · 30 Jun 2010 · 7,311 accessesView PDFCite
Research ArticleOpen accessIn the abstractProduction and Roles of Glial Tissue Inhibitor of Metalloproteinases-1 in Human Immunodeficiency Virus-1-Associated Dementia Neuroinflammation: A ReviewC. Chao, A. GhorpadeProblem statement: Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and its cognate targets, the Matrix Metalloproteinases (MMPs), were differentially expressed in human brain samples with or without HIV-1 infection or HIV-1 Encephalitis (HIVE). Approach: A through literature review demonstrated that cell culture models of Central Nervous System (CNS) cell types had been used to illustrate the intricate temporal patterns of TIMP-1/MMP expression, … …American Journal of Infectious Diseases, Vol. 5, Issue 4 · 31 Dec 2009 · 6,957 accessesView PDFCite
Research ArticleOpen accessIn the abstractKnowledge of the Most-at-Risk Populations about Human Immunodeficiency Virus PreventionA. Ebadian, V. Alli, H. Sedghi et al.Problem statement: In this study we tried to assess the knowledge of general population (15-45 years), injecting drug users, female sex workers, MSM and male prisoners about HIV prevention in Iran. Approach: Respondents are asked the following set of prompted questions: (a) Can we reduce the risk of HIV transmission by having sex with only one uninfected partner who has … …American Journal of Applied Sciences, Vol. 6, Issue 11 · 30 Nov 2009 · 6,542 accessesView PDFCite