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Research ArticleOpen accessIn the abstractAn Unusual Association between Chromoblastomycosis and Jorge Lobo’s Disease in the Same Patient from the Amazon RegionMaurimelia M. da Costa, Silvia H. Marques da Silva, Hugo J. R. Almeida et al.A clinical case of co-infection Cladophialophora sp. and Lacazia loboi is described and in a same patient with an 18-year history of verrucous plaques and parakeloidal nodular lesions. A 50-yearold man, a laborer, living in the Anajás city, Para, Brazil (rural Amazon region), was seen at the Evandro Chagas Institute’s ambulatory. Histopathological analysis revealed intense hyperplasia and hyperkeratosis of the … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 3 · 30 Sep 2008 · 7,751 accessesView PDFCite
Research ArticleOpen accessIn the abstractSolving Protein Folding Problem using Elitism-Based Compact Genetic AlgorithmAmr Badr, Ibtehal M. Aref, Basma M. Hussien, Yosr EmanProteins are vital components of living cells. A number of diseases such as Alzheimer's, Cystic fibrosis and Mad Cow diseases are shown to result from misfunctioning of proteins. Problem statement: Protein folding problem is the process of predicting the optimal 3D molecular structure of a protein, or tertiary structure, which is an indication of its proper function. Approach: An enhancement … …Journal of Computer Science, Vol. 4, Issue 7 · 31 Jul 2008 · 6,861 accessesView PDFCite
Research ArticleOpen accessIn the abstractCocaine: A Catalyst for Human Immunodeficiency Virus-Associated DementiaNavneet K. Dhillon, Milind Gadgil, Andy Rahardja et al.Injection drug use has been recognized as a major risk factor for AIDS from the outset of the epidemic. Cocaine, one of the most widely abused drugs in the United States can both impair the functions of macrophages and CD4+ lymphocytes and also activate HIV-1 expression in these cells. Cocaine is a multifactorial agent that acts globally to impair the … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 7,590 accessesView PDFCite
Research ArticleOpen accessIn the abstractMitochondrial Energy-Deficient Endophenotype in AutismJ. Jay Gargus, Faiqa ImtiazWhile evidence points to a multigenic etiology of most autism, the pathophysiology of the disorder has yet to be defined and the underlying genes and biochemical pathways they subserve remain unknown. Autism is considered to be influenced by a combination of various genetic, environmental and immunological factors; more recently, evidence has suggested that increased vulnerability to oxidative stress may be … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 11,518 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Microscopic Study of Language-Related Cortex in AutismEdith López-Hurtado, Jorge J. PrietoImpaired language function is a principle criterion for the diagnosis of autism. The present study of brain from age-matched autistic and control subjects compared brain regions associated with the production and processing of speech. Wernicke's area (Brodmann 22, speech recognition), Broca's area (Brodmann 44, speech production) andthe gyrus angularis (Brodmann 39, reading) from autistic subjects (7-44 years of age) and … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 8,547 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Autistic Phenotype Exhibits a Remarkably Localized Modification of Brain Protein by Products of Free Radical-Induced Lipid OxidationTeresa A. Evans, Sandra L. Siedlak, Liang Lu et al.Oxidative damage has been documented in the peripheral tissues of autism patients. In this study, we sought evidence of oxidative injury in autistic brain. Carboxyethyl pyrrole (CEP) and iso[4]levuglandin (iso[4]LG)E2-protein adducts, that are uniquely generated through peroxidation of docosahexaenoate and arachidonate-containing lipids respectively, and heme oxygenase-1 were detected immunocytochemically in cortical brain tissues and by ELISA in blood plasma. Significant … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 8,727 accessesView PDFCite
Research ArticleOpen accessIn the abstractTreatment of Stormwater Runoff and Landfill Leachates Using a Surface Flow Constructed WetlandA. Snow, A. E. Ghaly, R. CoteA surface flow wetland was constructed in the Burnside Industrial Park, Dartmouth, Nova Scotia, to treat stormwater runoff from the surrounding watersheds which are comprised primarily of commercial properties and two former landfills. The aim was to protect a freshwater ecosystem that consists of a 4.6 km long brook and two lakes. The ability of the constructed wetland to retain … …American Journal of Environmental Sciences, Vol. 4, Issue 2 · 30 Apr 2008 · 6,749 accessesView PDFCite
Research ArticleOpen accessIn the abstractIsolation and Characterization of Novel Metal Accumulating Extracellular Protease Secreting Bacteria from Marine Coastal Region of Digha in West Bengal, IndiaSusmita Roy, Kaushal Mishra, Sanhita Chowdhury et al.Problem statement: The objective of the present piece of work was to explore the existing biodiversity of protease secreting microbes in a marine ecosystem, the site selected being the coastal region of West Bengal (Digha), India. Approach: The culture dependent method was used for isolation and characterization of novel microbes from the point of biotechnological application. The isolate obtained was … …OnLine Journal of Biological Sciences, Vol. 8, Issue 1 · 31 Mar 2008 · 7,190 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormetic and Non-Hormetic Dose-Response Functions in Stress Effects on Memory and Synaptic Plasticity: Issues and MechanismsPhillip R. Zoladz, David M. DiamondOver a century of behavioral research has shown that stress can exert both positive and negative effects on memory. We have explored the idea that the complex effects of stress on learning and memory can be characterized by hormetic- and non-hormetic dose-response functions, in which stress may either stimulate or impair brain memory mechanisms, depending, in part, on the timing … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 8,188 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormetic Interventions in AgingSuresh I.S. RattanSingle or multiple exposure to low doses of potentially harmful agents can have a variety of anti-aging and longevity-extending hormetic effects. These hormetic stressors include irradiation, physical activity, food limitation, heat, hypergravity, dietary components and reactive oxygen species. Molecular mechanisms facilitating the hormetic effects are being elucidated and comprise a cascade of stress response and maintenance and repair pathways. Although … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,833 accessesView PDFCite