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Research ArticleOpen accessIn the abstractComparative Evaluation of Aqueous and Freeze Dried Antigen for Sero-diagnosis of VL and PKDL Cases by DATSanjiva Bimal, Shubhankar K. Singh, P. K. Sinha et al.The efficacy of aqueous and freeze dried (FD) antigen was evaluated by direct agglutination test (DAT) for sero-diagnosis of visceral leishmaniasis. A total of 16 samples collected from 5 confirmed Kala-azar (KA) cases, 6 cases 2 each of filariasis, malaria, leprosy and 5 non-endemic healthy subjects were used in determination of cut off titre of both the antigens in DAT. … …American Journal of Immunology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,834 accessesView PDFCite
Research ArticleOpen accessIn the abstractA New Method to Estimate Intrinsic Parameters in the Ping-pong Bisustrate Kinetic: Application to the Oxipolymerization of PhenolJosé L. Gómez, Antonio Bódalo, Elisa Gómez et al.A new method for determining the intrinsic parameters of reaction in processes involving a high initial rate has been developed. The usefulness of this alternative, which consists of determining several sets of apparent parameters at different times and then extrapolating these to time zero, is demonstrated proved by the linear dependence obtained between the apparent parameters and the reaction time. … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,531 accessesView PDFCite
Research ArticleOpen accessIn the abstractImatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma MembraneHans Prenen, Cristiana Stefan, Bart Landuyt et al.Imatinib mesylate, the inhibitor of the KIT protein tyrosine kinase that is constitutively activated in Gastrointestinal Stromal Tumors (GISTs), has been established as the first highly effective drug in the treatment of patients with advanced GISTs. Recent studies suggest that changes in the glucose metabolism could be an additional mechanism of the anti-proliferative action of imatinib. The aim of this … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,245 accessesView PDFCite
Research ArticleOpen accessIn the abstractPDX-1 and MafA: Key Transcription Factors in PancreasHideaki Kaneto, Takeshi Miyatsuka, Yoshihisa Nakatani, Taka-aki MatsuokaPancreatic and duodenal homeobox factor-1 (PDX-1) plays a crucial role in pancreas development, β-cell differentiation and in maintaining normal β-cell function by regulating several β-cell-related genes including insulin. PDX-1 has potency to induce insulin-producing cells in non β-cells in various tissues such as pancreas and liver and PDX-1-VP16 fusion protein more efficiently induces insulin-producing cells, especially in the presence of … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,389 accessesView PDFCite
Research ArticleOpen accessIn the abstractY: A New Component-Based Software Life Cycle ModelLuiz F. CapretzWith the need to produce ever larger and more complex software systems, the use of reusable components has become increasingly imperative. Of the many existing and proposed techniques for software development, it seems clear that component-based software development will be at the forefront of new approaches to the production of software systems and holds the promise of substantially enhancing the … …Journal of Computer Science, Vol. 1, Issue 1 · 31 Mar 2005 · 7,396 accessesView PDFCite
Research ArticleOpen accessIn the abstractExtracts of Pumpkin (Cucurbita pepo L.) Seeds Suppress Stimulated Peripheral Blood Mononuclear Cells in vitroChristiana Winkler, Barbara Wirleitner, Katharaina Schroecksnadel et al.In the traditional medicine in North America and Mexico, pumpkin seeds have been used as an anthelmintic agent and for supportive treatment in functional disorders of the bladder. Also anti-inflammatory and cardioprotective activity of pumpkin seeds is discussed. Three different extracts of pumpkin seeds were prepared and effects were investigated in unstimulated human peripheral blood mononuclear cells and in cells … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 10,711 accessesView PDFCite
Research ArticleOpen accessIn the abstractHydrogen Peroxide Biosensor Based on the Direct Electrochemistry of Myoglobin Immobilized in Poly-3-Hydroxybutyrate FilmXiang Ma, Rongwu Yang, Genxi LiDirect electrochemistry of myoglobin (Mb) was observed in a stable film composed of a natural lipid polymer (poly-3-hydroxybutyrate) and Mb, the film of which was modified on a pyrolytic graphite electrode. The apparent formal potential of Mb was at about -260 mV in an acetate buffer solution with pH 5.0. Moreover, Mb in the polymer film exhibited catalytic activity towards … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,872 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Development of a New, Rapid, Amperometric Immunosensor for the Detection of Low Concentrations of Bacteria Part II: Optimization of the System for Escherichia coliEric Carnes, Ebtisam WilkinsThe optimization of a flow-through immunoassay system was conducted to achieve rapid detection of low concentrations of E. coli bacteria. The system includes a new immunosensor that uses newly developed, disposable immunofiltration membranes to yield a system that is sensitive as well as simple. Comparison of the performance of this system with conventional immunoassays demonstrated a significantly shorter time for … …American Journal of Applied Sciences, Vol. 2, Issue 3 · 31 Mar 2005 · 6,780 accessesView PDFCite
Research ArticleOpen accessIn the abstractProduction of Cellulase from Oil Palm Biomass as Substrate by Solid State BioconversionMd. Z. Alam, Nurdina Muhammad, Mohd E. MahmatSolid state bioconversion (SSB) of lignocellulosic material oil palm biomass (OPB) generated from palm oil industries as waste was conducted by evaluating the enzyme production through filamentous fungus in lab-scale experiment. OPB in the form of empty fruit bunches (EFB) was used as the solid substrate and treated with the fungus Trichoderma harzianum to produce cellulase. The results presented in … …American Journal of Applied Sciences, Vol. 2, Issue 2 · 28 Feb 2005 · 7,440 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Conceptual Design of the Concurrent Engineering Design System for Polymeric-Based Composite Automotive PedalsS. M. SapuanIn this study, a study of conceptual design for the polymeric-based composite automotive pedal box system is presented. This study describes the importance of the concurrent engineering technique in the total design activity. Several idea generation methods like the extension of the search space, the morphological chart, the exploitation of experiences, the gallery method and the voice of customer had … …American Journal of Applied Sciences, Vol. 2, Issue 2 · 28 Feb 2005 · 7,727 accessesView PDFCite