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126 results for “inhibitory effect”
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Research ArticleOpen accessIn the abstractIn Silico and in Vitro Studies: Tryparedoxin Peroxidase Inhibitor Activity of Methotrexate for Antileishmanial ActivityRavi Kumar Gundampati, Shraddha Sahu, Avinash Kumar Srivastava et al.In order to understand the mechanism of molecular interactions at the active site of Tryparedoxin Peroxidase (Try P), homology modeling and docking studies were performed. We generated a Three-Dimensional (3D) model of target protein based on the Crystal structure of Leishmania Major Try PI (PDB ID: 3TUE) using modeler software. Docking analysis was carried out to study the effects of … …American Journal of Infectious Diseases, Vol. 9, Issue 4 · 28 Nov 2013 · 7,893 accessesView PDFCite
Research ArticleOpen accessIn the abstract2-D Gel Electrophoresis Map of Methicillin-Resistant Staphylococcus aureus Treated with Quercus Infectoria Gall ExtractDayang Fredalina Basri, Lee Seng Aik, Radhiah Khairon, Mariati Abdul RahmanThe widespread outbreak of Methicillin-Resistant Staphylococcus Aureus (MRSA) has caused clinical and epidemiological concern in hospital environment. The emergence of Vancomycin-Intermediate S. Aureus (VISA) and, more recently, Vancomycin-Resistant S. Aureus (VRSA) has further alarmed clinician and scientist worlwide. The objective of this study is to determine the optimum concentration of sample protein from MRSA after treatment with acetone extract from … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 1 · 18 Mar 2013 · 7,994 accessesView PDFCite
Research ArticleOpen accessIn the abstractBacteriological Examination of Computer Keyboards and Mouse Devices and Their Susceptibility Patterns to DisinfectantsOnochie Charles Chimezie, Anyim Chukwudi, Alo Moses Nnaemeka et al.Computers are ubiquitous and have been shown to be contaminated with potentially pathogenic bacteria in some communities. There is no economical way to test all the keyboards and mouse out there, but there are common-sense ways to prevent bacterial contamination or eliminate it if it exists. In this study, swabs specimens were collected from surfaces of 250 computer keyboards and … …Current Research in Microbiology, Vol. 4, Issue 1 · 19 Jan 2013 · 13,509 accessesView PDFCite
Research ArticleOpen accessIn the abstractLemon Pepper Fruit Extract (Zanthoxylum acanthopodium DC.) Suppresses the Expression of Inflammatory Mediators in Lipopolysaccharide-Induced Macrophages In VitroYanti, Theodorus Eko Pramudito, Nerissa Nuriasari, Katarina JulianaProblem statement: Lemon pepper fruits (Zanthoxylum acanthopodium DC.; Rutaceae) have been used as a traditional source against stomach ache by Batak people in North Sumatera province, Indonesia. However, its scientific evidence for treatment of inflammatory disorders particularly gastritis has not been reported. Approach: Here, we investigated the inhibitory effects of Lemon Pepper Fruit Extract (LPFE) against inflammatory biomarkers by conducting … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 4 · 14 Feb 2012 · 9,581 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesign, Synthesis, Biological Screening and Structure Activity Relationship Study of 4, 6-Dimethyl-2-(Substituted) Mercapto-3-(Substituted) Pyridines as Anti Tubercular AgentsMehul M. Patel, Mahesh T. ChhabriyaProblem statement: Tuberculosis is a leading global mortality factor which has not been effectively controlled, with 1.7 million deaths per year and 8.9 million new cases. Aerobic microbe Mycobacterium tuberculosis H37Rv (MTB) is the causative agent of tuberculosis. Although many active antitubercular agents have since been developed, drug resistance will continue to be a problem. Therefore, there is a clear … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,430 accessesView PDFCite
Research ArticleOpen accessIn the abstractIncorporation of Bentazone with Exserohilum rostratum for Controlling Cyperus iriaFranklin Ragai Kundat, Loo Hong Shen, Osumanu Haruna AhmedProblem statement: Various methods are used to counter the population of Cyperus iria in rice fields and among the most common method are chemical approaches. Chemical control methods are preferred by rice farmers due to their efficacy, speed, ease of storage and affordable cost. The concern of chemical herbicides is on its effects on the environment. Less attention had been … …American Journal of Agricultural and Biological Sciences, Vol. 5, Issue 2 · 5 Sep 2011 · 9,525 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Metalloproteinase-9 Activities of Selected Indonesian Zingiberaceae Rhizome Extracts in Lipopolysaccharide-Induced Human Vascular Endothelial Cells In VitroYantiProblem statement: Atherosclerosis is associated with chronic inflammation triggered by bacterial infection that activates the breakdown of extracellular matrix protein by matrix Metalloproteinases (MMPs). Zingiberaceae, a group of tropical food crops grown in Indonesia and other Southeast Asia regions, has been traditionally used for food coloring, seasoning, culinary and medicinal purposes. However, its efficacy as natural vascular protection has not … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 1 · 27 May 2011 · 7,869 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Inhibition of Human Pathogens: Trichophyton rubrum and Trichoderma harzianum by a Natural ProductRand R. Hafidh, A.S. Abdulamir, Law Se Vern, Fatimah Abu BakarProblem statement: A number of studies have recently conducted to identify novel and potent antifungal components from natural products. One of the reasons is to overcome the antifungal resistant developed against most of commercially available drugs. Studies confirmed that mung beans have increased phenolic compounds and enhanced defenses during germination. Approach: We hypothesized that antifungal activities might be found in … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 9,361 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Inflammatory Activity of Vitex leucoxylon L. Bark Extracts Against Freund's Complete Adjuvant Induced Arthritis in Sprague Dawley RatAlluri V. Krishnaraju, Chundi B.M. Rao, Dodda Sundararaju et al.Problem statement: Anti-inflammatory agents, particularly steroids and cyclooxygenase inhibitors are often associated with adverse side effects including, GI irritation, ulcers, hypertension and cardiac abnormalities. A safe and effective intervention is essential for the treatment of inflammatory disorders. Approach: Abstract Vitex leucoxylon L., a medicinal plant of the verbenaceae family, used in traditional medicine for relieving headache and catarrh. VL-89/185A, was … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 8,044 accessesView PDFCite
Research ArticleOpen accessIn the abstractVariations in Four Genotypes of Lentil under NaCl-Salinity StressM. Sidari, C. Santonoceto, U. Anastasi et al.Four lentil cultivars, Eston (E), Rossa of Castelluccio (RC), Pantelleria (P) and Ustica (U) differing in salt sensitivity, were examined for osmolyte contents and activities of α-amylase, β-amylase and α-glucosidase enzymes involved in seed germination, in absence as well as in presence of 50, 100, 150 and 200 mM NaCl. The inhibitory effects of NaCl differed, depending on the genotypes … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 8,702 accessesView PDFCite