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158 articles for “Mice”
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Research ArticleOpen accessIn the abstractAqueous Extract of Inonotus bliquus (Fr.) Pilat (Hymenochaetaceae) Significantly Inhibits the Growth of Sarcoma 180 by Inducing ApoptosisCaifa Chen, Weifa Zheng, Xiaowen Gao et al.Inonotus obliquus (Fr.) Pilat (Hymenochaetaceae) has been widely used as a folk medicine to treat various cancers in Russia, Poland and most of Baltic countries for literally more than four centuries. However, in spite of its therapeutic significance for cancers, this fungus has not been studied systematically for the mechanisms of antitumor activity. In this study, we report the effects … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 21,115 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunological Evidence for Peptide-Carbohydrate Mimicry with a Group A Streptococcus Polysaccharide-Mimetic PeptideSilvia Borrelli, Rehana B. Hossany, Susan Findlay, B. Mario PintoThe immunogenicity of a peptide-protein conjugate developed by linking a peptide mimic DRPVPY of the Group A Streptococcus cell-wall polysaccharide (GAS-CWPS), to tetanus toxoid (TT) was examined. BALB/c mice were immunized three times subcutaneously following homologous or heterologous prime/boost strategies at 4- or 6- week intervals in two different experiments. DRPVPY-TT, CWPS-TT, heat-killed, pepsin-treated GAS bacteria (with exposed polysaccharide) and … …American Journal of Immunology, Vol. 2, Issue 4 · 31 Dec 2006 · 6,960 accessesView PDFCite
Research ArticleOpen accessIn the abstractUltrastructural and Immunological Characterization of Hepatitis C Core Protein-DNA Plasmid ComplexesNelson Acosta-Rivero, Yaraima Aguilera, Viviana Falcon et al.Recently, it has been shown that a truncated HCV core (HCcAg) variant, covering the first 120 aa (HCcAg.120), interacts with plasmid DNA vaccine (pIDKE2), encoding the HCV structural proteins (HCcAg, E1 and E2). In the present work, HCcAg.120-pIDKE2 complexes, forming heterogeneous packaged structures, were visualized using a negative stain/rotary shadow technique. Interestingly, 72 hours after intramuscular injection of HCcAg.120-pIDKE2 complexes … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,746 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Anti-Inflammatory Potential of Turmimax® an in vivo and in vitro StudyFiroz Hussain H M., Nanjundaiah S., Sadashiva Channangihalli Thimmegowda et al.The main objective of this study was to investigate the in vivo and in vitro anti-inflammatory effects of the Turmimax® bio-enhanced turmeric formulation. By comparing the relative fluorescence intensities of the interleukins IL-8 (Interleukin-8) and IL-12 (Interleukin-12) cytokines in stimulated murine Raw 264.7 macrophages, Turmimax® was evaluated for its anti-inflammatory in vitro efficacy. Turmimax® was administered orally in two doses, … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 24 Nov 2022 · 6,587 accessesView PDFCite
Research ArticleOpen accessIn the abstractRadiation Triggered Phenotypic Changes of Regulatory T CellsLantao Liu, Yan Peng, Deqin Zhang, Dongsheng NiuIonizing radiation disrupts the immune balance easily. Regulatory T (Treg) cells directly affect the immune balance after radiation exposure. Meanwhile, the present study is to investigate the survival ability and phenotypic changes of Treg cells induced by 60Co γ-rays in order to expand the understanding on how Treg cells modulated by radiation. Mice lymphocytes were isolated from thymus and spleen … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 1 · 20 Mar 2022 · 5,830 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntioxidant, Analgesic and Anti-inflammatory Effects of Ethanolic Extract of Moroccan Lavandula stoechas L.Hind Ferehan, Mehdi Ait Laaradia, Sara Oufquir et al.Lavandula stoechas L. is a widely used medicinal plant. In Moroccan traditional medicine, it is employed for the treatment of different illness and as an anxiolytic, analgesic or anti-inflammatory remedy. The purpose of this investigation was to assess the antioxidant, antinociceptive and anti-inflammatory effects of the ethanolic extract of Moroccan Lavandula stoechas L. in animal models. Therefore, in vitro anti-oxidant … …OnLine Journal of Biological Sciences, Vol. 21, Issue 4 · 15 Feb 2022 · 5,891 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Antinociceptive Effects of Central and Peripheral Administration of Peganum harmala L. Extracts in Animal ModelsRachida Aboufatima, Loubna Farouk, Mehdi Ait Laaradia et al.The medicinal plant Peganum harmala has been used in traditional Moroccan medicine to accelerate the healing process of various diseases and to relieve the pain. The antinociceptive effect of the Aqueous (AE), Dichloromethane (DE) and Butanolic (BE) extracts of the Peganum harmala L. was tested in mice and rats by chemical and thermal models. Plant seed extracts were given intraperitoneally … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 29 May 2021 · 6,424 accessesView PDFCite
Research ArticleOpen accessIn the abstractReduced Levels of Testosterone Induce LDL Oxidation and Atherosclerotic Lesions Involving Inflammatory Imbalance and Reduced Macrophage ApoptosisPlacielle Fiorezi Filete, Flávia de Souza Andrade Moraes, Girlandia Alexandre Brasil et al.Atherosclerosis is among the major cardiovascular diseases that cause death in the world. Men who are deficient in androgen hormones are more susceptible to this disease. The aim of this study was to evaluate the influence of reduced levels of testosterone on the lipid profile, pro and anti-inflammatory cytokines, apoptosis of peritoneal macrophages and the development of atherosclerosis in LDLr-/-mice, … …OnLine Journal of Biological Sciences, Vol. 19, Issue 4 · 6 Dec 2019 · 7,342 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Vitro Immunomodulatory and Cytotoxic Potentials of Faloak (Sterculia quadrifida R.Br.) BarkTriana Hertiani, Purwantiningsih, Aji Winanta et al.Faloak (Sterculia quadrifida R.Br., Sterculiaceae) is an Indonesia indigenous plant widely used as a traditional remedy for various health complaints. This study aimed to explore the immunomodulatory and cytotoxicity potentials of Faloak bark by using in vitro techniques. Barks was extracted using water, ethanol and ethanol: water (1:1) separately. Colorimetric analysis was used for the determination of the total phenolic … …OnLine Journal of Biological Sciences, Vol. 19, Issue 4 · 6 Nov 2019 · 8,063 accessesView PDFCite
Research ArticleOpen accessIn the abstractOptimization of Cellulase-Assisted Extraction of Total Flavonoids from Corn Bract and Evaluation of Antioxidant and Antibacterial AactivitiesYang Zhang, Jing Lu, Leijie Ben et al.Corn bract is a corn-based agricultural waste material that distributed worldwide. In present work, response surface methodology was applied to optimize the cellulase-assisted extraction of Total Flavonoids from Corn Bract (TFCB), the in vitro antioxidant and antibacterial as well as the in vivo antioxidant activities of TFCB were investigated. Results showed that the optimal conditions for TFCB extraction were as … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 2 · 18 May 2019 · 8,505 accessesView PDFCite