134 results for “ADR”

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Research ArticleOpen accessIn the abstractAdverse Drug Reaction Detection Using Latent Semantic AnalysisAhmed Adil Nafea, Nazlia Omar, Mohammed M. AL-AniDetecting Adverse Drug Reactions (ADRs) is one of the important information for determining the view of the patient on one drug. Most studies have investigated the extraction of ADRs from social networks, in which users share their opinion on a particular medication. Some studies have used trigger terms to detect ADRs. Such studies showed remarkable performance in terms of extracting … …Journal of Computer Science, Vol. 17, Issue 10 · 28 Oct 2021 · 7,816 accessesView PDF Cite

Research ArticleOpen accessIn the abstractExtended Trigger Terms for Extracting Adverse Drug Reactions in Social Media TextsRami Naim Mohammad Yousef, Sabrina Tiun, Nazlia OmarAdverse Drug Reaction (ADR) is a disorder caused by taking medications. Studies have addressed extracting ADRs from social networks where users express their opinion regarding a specific medication. Extracting entities mainly depends on specific terms called trigger terms that may occur before or after ADRs. However, these terms should be extended, especially when examining multiple representation of N-gram. This study … …Journal of Computer Science, Vol. 15, Issue 6 · 29 Jun 2019 · 8,058 accessesView PDF Cite

Research ArticleOpen accessIn the abstractQuercetin Iron (III) Complex Enhances Radiation-Induced Cell Death in Human Erythroleukemic Cell Lines by Increasing the Generation of Intracellular ROSJiraporn Kantapan, Krai Daowtak, Kachaporn Gateprayoon et al.Quercetin iron (III) complex (IronQ) is a paramagnetic agent which exhibits several biological effects. Despite extensive studies about quercetin metal complex, the role of complexes to enhance the effect of radiation still remains unexplored. To this end, we determined whether and how IronQ sensitizes cancer cells to Ionizing Radiation (IR). Doxorubicin resistant leukemic cells (K562/Adr) and their parental cell lines … …American Journal of Applied Sciences, Vol. 14, Issue 1 · 16 Jan 2017 · 8,068 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Effect of Phyllanthus taxodiifolius Beille Extracts and its Triterpenoids Studying on Cellular Energetic Stage of Cancer CellsPatiwat Sakkrom, Wilart Pompimon, Puttinan Meepowpan et al.Problem statement: The Multidrug Resistance phenomenon (MDR) is the cause of unsuccessful in cancer chemotherapy. The tradition plant is the population used as the alternative medicine in cancer therapy. Due to, P. taxodiifolius is medicinal Thai plant which is used as diuretic drug which has never been explored as the anticancer activities. Approach: Air-dried powder of P. taxodiifolius leaves and … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 8,753 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAntiproliferative Effects of Alkaloids Isolated from the Tuber of Stephania venosa via the Induction of Cell Cycle Arrest in Mammalian Cancer Cell LinesSirinapa Nantapap, Chatchanok Loetchutinat, Puttinan Meepowpan et al.Problem statement: S. venosa (Menispermaceae) is used in traditional medicine. The constituents of S. venosa belonging to showed remarkable cytotoxic activity. According to previous research, S. venosa contains several alkaloids, such as protoberberine stephanine cyclanoline and N-methylstepholidine, kamaline, (+)-N-carboxamidostepharine, (-)-O-methylstepharinosine, (-)-stepharinosine, aporphine (-)-O-acethylsukhodiamine and oxostephanosine. The chemical and biological investigations of this plant are interesting to bioassay-guided fractionation, particularly Antiproliferative … …American Journal of Applied Sciences, Vol. 7, Issue 8 · 31 Aug 2010 · 8,794 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAnticancer Activities of Styrylpyrone from the Leaves and Twigs of Goniothalamus maewongensis via Cell Cycle ArrestPradit Pradupsri, Chatchanok Loetchutinat, Narong Nuntasaen et al.Problem statement: Goniothalamus maewongensis is one of three new species which are found in Thailand recently. The genus goniothalamus is not only well known for the rich of styrylpyrones but also famous for the potential of biological activities, especially the cytotoxic activity against a number of human cancer cell lines. The phytochemical and biological investigations of this plant are interesting … …American Journal of Applied Sciences, Vol. 6, Issue 12 · 31 Dec 2009 · 8,195 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIdentification and Antiproliferative Activity Evaluation of a Series of Triterpenoids Isolated from Flueggea virosa (Roxb. ex Willd.)Sod Monkodkaew, Chatchanok Loetchutinat, Narong Nuntasaen, Wilart PompimonProblem statement: Medicinal plants derived anticancer were now being subjects of many research groups especially, the secondary metabolite triterpenoids trees which had enormous potential to inspire and influence modern antiproliferative research. The study aimed to investigate the chemical constitution and their potential use as antiproliferative activity of purified compounds derived from F. virosa. Approach: The F. virosa was selected and … …American Journal of Applied Sciences, Vol. 6, Issue 10 · 30 Oct 2009 · 7,633 accessesView PDF Cite

Research ArticleOpen accessIn the abstractP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,508 accessesView PDF Cite

Review ArticleOpen accessIn the abstractFrom Health to Disease: Functional Insights of Scavenger Receptor Class B Type I in Lipid Metabolism and Disease PathogenesisSujina Simon Sailet, Poornima Ajay Manjrekar, Santosh Rai et al.Scavenger receptor class B type I (SR-B1) has caught considerable interest among the scientific community due to its pivotal role in several biological and pathological processes. It is a multifunctional integral membrane protein and multiligand receptor encoded by the SCARB1 gene. SR-B1 has a wide distribution, primarily in the liver as well as steroidogenic organs including the gonads and adrenal … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 11 Jul 2025 · 3,672 accessesView PDF Cite

Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 13,008 accessesView PDF Cite