103 articles for “Injury”

Research ArticleOpen accessIn the abstractInflammatory Cytokine Expression Patterns in Rat Skin Exposed to JP-8 Jet FuelRandle M. Gallucci, Bethany M. MickleOne of the main complaints of personnel exposed to JP-8 jet fuel is irritant dermatitis. The purpose of this investigation is to describe the JP-8 induced inflammatory cytokine response in skin over various periods of exposure. JP-8 jet fuel or acetone control (300 μL) was applied to the denuded skin of rats once a day for up to seven days. … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,042 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRole of HIV-1 Infection in Addictive Behavior: A Study of a HIV-1 Transgenic Rat ModelSulie L. Chang, Michael VigoritoEpidemiological research indicates that drug abuse is prevalent among individuals infected with HIV-1. Evidence from preclinical research also suggests that drugs of abuse exacerbate the progression of neuropathological changes in the HIV-1 infected brain probably through common mechanisms of neuronal injury. The effects of HIV-1 on the efficacy and abuse potential of controlled drugs such as morphine, however, has not … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 7,630 accessesView PDF Cite

Research ArticleOpen accessIn the abstractOpiates Upregulate Adhesion Molecule Expression in Brain MicroVascular Endothelial Cells (BMVEC): Implications for Altered Blood Brain Barrier (BBB) PermeabilityMadhavan P.N. Nair, Supriya D. Mahajan, Jessica L. ReynoldsThe blood-brain barrier (BBB) is an intricate cellular system composed of vascular endothelial cells and perivascular astrocytes that restrict the passage of immunocompetent cells into the central nervous system (CNS). Expression of the adhesion molecules, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on brain microvascular endothelial cells (BMVEC) and their interaction with human immunodeficiency virus (HIV-1) … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 6,610 accessesView PDF Cite