Review ArticleOpen accessIn the abstractThe HCV Replicase InteractomeAntonio Mas, Pilar Clemente-Casares, Eugenio Ramírez, Rosario SabariegosViruses are obligate parasites and can only reproduce within host cells because they lack metabolic pathways to complete their replication cycles. Host factors required in viral replication are mainly those involved in lipid metabolism, cell cycle control and apoptosis, cell-to-cell interactions, immune system regulation, etc. Several inhibitors targeting viral polymerases have been designed. However, the rapid appearance of resistant mutants, … …Current Research in Virology, Vol. 5, Issue 1 · 27 Jul 2016 · 13,210 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Duality of AIM2 Inflammasome: A Focus on its Role in Autoimmunity and Skin DiseasesMiriam CanaveseUnderstanding the inflammasome biology is one of the most exciting challenges in immuno-pharmacology. The role of the inflammasomes has been recognized in the host defense mechanism against invading pathogens and in the development of several conditions, such as cancer, auto-inflammatory, autoimmune, metabolic and neurodegenerative disorders. DNA recognition by the cells is a crucial immunological step leading to the initiation of … …American Journal of Pharmacology and Toxicology, Vol. 11, Issue 1 · 23 Apr 2016 · 7,369 accessesView PDFCite
Literature ReviewOpen accessIn the abstractThe Practical Consideration of Poliovirus as an Oncolytic VirotherapyElizabeth Denniston, Hannah Crewdson, Nicole Rucinsky et al.The inauguration of novel treatment strategies into the clinical setting faces a number of hurdles. In addition to treatment efficacy and safety, acceptance by doctors and patients is paramount to the success of novel therapies. Although viruses are the cause of numerous infectious diseases, these acellular entities have been harnessed over the years to benefit mankind. Recently, a recombinant Poliovirus-Rhinovirus … …Current Research in Virology, Vol. 5, Issue 1 · 3 Mar 2016 · 27,150 accessesView PDFCite
Research ArticleOpen accessIn the abstractFlow Cytometry Baseline on Peripheral Leukocyte Cell Profiles for Dairy Goat KidsDarcy M. Fletcher, Megan B. Vogt, Hannah E. Pirner et al.Small ruminants, like goats, would make excellent animal models for not only infectious diseases in large ruminants but also analogous diseases in humans, such as human tuberculosis, Crohn’s disease, melioidosis and brucellosis. The main disadvantage for the small ruminant model is the lack of sufficient baseline data on normal, healthy goat kids. Furthermore, most reagents (antibodies and the like) were … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 4 · 26 Sep 2013 · 7,572 accessesView PDFCite
Research ArticleOpen accessIn the abstractA True "Candidate Ig Kappa Gene" in the Sea-Star: Asterias rubens (Echinoderma)Michel Leclerc, Patricia Otten, Magne OsterasThe axial organ of the sea-star Asterias rubens is a primitive immune organ. The B-like cells, when stimulated by various antigens, produce antibody substances correlated with Ig Kappa gene. A candidate Ig kappa gene (IgK chain V-IV region S107B precursor) more convincing in term of genome was shown. …American Journal of Immunology, Vol. 9, Issue 3 · 20 Aug 2013 · 7,222 accessesView PDFCite
Research ArticleOpen accessIn the abstractComplement Genes in the Asterids Comparisons with the Echinids (Echinoderma)Michel LeclercThe axial organ of the sea star Asterias rubens (Asterid) is a primitive immune organ. The B-like cells, when stimulated by various antigens, produce antibody substances correlating with ig kappa genes. On the other hand, component complement genes were found. For each component, one or several contigs were analysed. It is said that Asterias forbesi, another sea-star, in earlier results, … …American Journal of Immunology, Vol. 9, Issue 1 · 26 Feb 2013 · 7,472 accessesView PDFCite
Research ArticleOpen accessIn the abstractHow Micrornas Affect the Expression of Human Leukocyte Antigeng in PregnancyAyla Carmel Kempers, Marie Van Dijk, Cees OudejansThe expression of Human Leukocyte Antigen G (HLA-G) on Fetal Extravillous Trophoblast (EVT) cells during pregnancy plays an important role in preventing the fetus from rejection by suppressing the maternal immune system. Decreased expression levels of HLA-G have already shown to be associated with several complications of pregnancy such as pre-eclampsia. However, it remains largely unknown how HLA-G gene expression … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Oct 2012 · 7,124 accessesView PDFCite
Research ArticleOpen accessIn the abstractPlatelets, Coagulation and Cancer: Multifaceted InteractionsT. Burnouf, H. A. GoubranApproach: Literature review of the multifaceted interactions between platelets, coagulation and cancer. Results: Over the years, the links existing between cancer development, progression and occurrence of metastasis on one side and coagulation on the other have become obvious. Tumors seems to activate platelets whereas, platelets, on the other hand, through their capacity to activate and release soluble factors and microparticles, … …Current Research in Medicine, Vol. 3, Issue 2 · 30 Jul 2012 · 7,613 accessesView PDFCite
Research ArticleOpen accessIn the abstractZero Geometry, Zero Space Time, The Seeds of The Final TheoryKambiz-AfrasiabiProblem statement: Lack of understanding And scientific formulation of zero geometry and zero space-time and the truth about initiation conditions would continue to keep us all in dark and we would continue to create more theories defining our observations about the known universe which could Indeed be part of our illusionary perception of reality And as long as they continue … …American Journal of Applied Sciences, Vol. 8, Issue 11 · 10 Oct 2011 · 7,846 accessesView PDFCite