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140 articles for “Drug Problem”
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Research ArticleOpen accessIn the abstractCharacterization of Escherichia coli Isolates from Commercial Layer Hens with SalpingitisMahmood Salehi, Reza GhanbarpourProblem statement: Escherichia coli isolates are the most common bacterial agents of salpingitis in commercial layer hens. The objectives of this study were to determine the phylogenetic groups/subgroups and antibiotic resistance of E. coli isolates from salpingitis cases in commercial layer hens farms in southeast of Iran. Approach: One hundred twenty one E. coli isolates from oviducts of layer hens … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 3 · 30 Sep 2010 · 8,955 accessesView PDFCite
Research ArticleOpen accessIn the abstractDensity Functional Theory Based Quantitative Structure Activity Relationship Study of 2,5-Bis(1-Aziridinyl)-p-Benzoquinones with Lymphoid LeukemiaBahjat A. Saeed, Rita S. EliasProblem statement: QSAR techniques increase the probability of success and reduce time and coast in drug discovery process. The study presented QSAR investigation on 32 bioactive aziridinylbenzoquinones that have activity against lymphoid leukemia. Approach: Molecular descriptors, molecular weight, total energy, hardness, chemical potential, electrophilicity index, HOMO and LUMO energies were calculated. Initial geometry optimizations were carried out with the AM1 … …American Journal of Applied Sciences, Vol. 7, Issue 7 · 31 Jul 2010 · 7,216 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Comparative Study between Norethisterone Progestogens and Dydrogesterone in the Treatment of Dysfunctional Uterine BleedingNabila K. YaaqoubProblem statement: To compare the effects of both Norethisterone Progestongens and Dydrogesterone in the treatment of Dysfunctional Uterine bleeding Design: A prospective study. Setting: Tikrit Teaching Hospital, Iraq. Approach: About 200 patients presented with abnormal uterine bleeding and diagnosed as dysfunctional uterine bleeding were included in this study. Group A (study group): Include 100 patients were treated with norethisterone progestogens. … …Current Research in Medicine, Vol. 1, Issue 1 · 30 Jun 2010 · 15,140 accessesView PDFCite
Research ArticleOpen accessIn the abstractCardioprotective Effect of Lagenaria siceraria (Molina) Standley (Cucurbitaceae) Fruit Juice on Doxorubicin Induced Cardiotoxicity in RatsM. Hassanpour Fard, G. Naseh, S. L. Bodhankar, M. DikshitProblem statement: The cardio toxicity of Doxorubicin (Dox) has limited its use as an anticancer drug. The aim of present study was to investigate the cardio protective effect of Lagenaria Siceraria (Cucurbitaceous) Fruit Juice (LSFJ) against the cardio toxicity of Dox in rats. Approach: Male wistar rats (250-300 g) were randomly divided into four groups. Group I- was control, Group … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 8,519 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Case of Refractory Salmonella Spondylodiscitis in an Immunocompetent Patient Treated Via an Extracavitary Approach, Corpectomy and Placement of Expandable CageKimon Bekelis, Oren Gottfried, Zyia L. Gokaslan et al.Problem statement: Salmonella spondylodiscitis is a rare condition that is more prevalent in patients with sickle cell disease or immunosuppression. However, it can also be found in immunocompetent patients. It usually responds well to proper antibiotics. However, surgery is rarely indicated when the infection is refractory to antibiotics, the spine is destabilized or there is an epidural component that is … …American Journal of Infectious Diseases, Vol. 6, Issue 2 · 30 Jun 2010 · 7,535 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin, Quercetrin Except Rutin Potentially Increased Pirarubicin Cytotoxicity by Non-Competitively Inhibiting the P-Glycoprotein-and MRP1 Function in Living K562/adr and GLC4/adr CellsWinit Choiprasert, Nathupakorn Dechsupa, Suchart Kothan et al.Problem statement: Quercetin and its glycoside derivatives are increasingly receiving interests as new generation of anticancer molecules and were recognized by multidrug resistant transporters such as P-glycoprotein and MRP1 protein. Of relevance to their use as anticancer agents alone or in combination with other agents, this study aims to analyze the interaction of the compounds with the MDR transporters including … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 9,673 accessesView PDFCite
Research ArticleOpen accessIn the abstractMethicilin Resistant Staphylococcus aureus Carriage amongst Healthcare Workers of the Critical Care Units in a Nigerian HospitalA. Fadeyi, B.O. Bolaji, O.O. Oyedepo et al.Problem statement: Methicilin Resistant Staphylococcus Aureus (MRSA) Nosocomial Infection (NI) outbreaks and prevalence among various populations are well reported in literature particularly for developed countries. NI due to MRSA is a known cause of increased hospital stay, cost, morbidity and mortality especially among the critically ill. There is paucity of information on MRSA in developing nations including the carriage by … …American Journal of Infectious Diseases, Vol. 6, Issue 1 · 31 Mar 2010 · 9,104 accessesView PDFCite
Research ArticleOpen accessIn the abstractAspirin in Cardiovascular and Cerebrovascular Events: Does Market Failure Matter?Roger Lee MendozaProblem statement: Against the backdrop of the 2009 scientific studies qualifying the cardiovascular and cerebrovascular benefits of aspirin, two interrelated questions are raised for investigation in this study. First, why may the government intervene in an otherwise private transaction between physician and patient and between drug manufacturer and buyer, when it involves contentious pharmacological information? Second, does government intervention make … …American Journal of Economics and Business Administration, Vol. 2, Issue 1 · 31 Mar 2010 · 8,438 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe "Forgotten Side Effect" of ThiazidesArnon BlumProblem statement: Thiazide diuretics are derived from benzodiazines. They inhibit Na+/Cl- re-absorption from the distal convoluted tubules in the kidneys by blocking the thiazide-sensitive Na+/Cl- symporter. They are recommended as first line treatment for hypertension in the US (JNC VII)[1] guidelines and in the National Institute of Health and Clinical Excellence/British Hypertension Society guidelines[2] and in the European (ESC/ESH)[3] guidelines. … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 8,339 accessesView PDFCite
Research ArticleOpen accessIn the abstractKnowledge of the Most-at-Risk Populations about Human Immunodeficiency Virus PreventionA. Ebadian, V. Alli, H. Sedghi et al.Problem statement: In this study we tried to assess the knowledge of general population (15-45 years), injecting drug users, female sex workers, MSM and male prisoners about HIV prevention in Iran. Approach: Respondents are asked the following set of prompted questions: (a) Can we reduce the risk of HIV transmission by having sex with only one uninfected partner who has … …American Journal of Applied Sciences, Vol. 6, Issue 11 · 30 Nov 2009 · 6,542 accessesView PDFCite