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154 results for “Cancer Cell”
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Research ArticleOpen accessIn the abstractEarly Diagnosis of Breast Cancer using Molecular, Biochemical and Pathological MarkersSalah El-Din El-Assal, Adel A. El-Tarras, Samir M. Abd-allaProblem statement: Laboratory diagnosis of breast cancer in most of the hospitals has traditionally been performed using cell culture and the direct hormone receptor assay, which are money and time consuming. Approach: This study was performed in order to direct the attention toward increasing the efficiency of early diagnosis in clinical laboratories at the western region of KSA and Egypt … …American Journal of Applied Sciences, Vol. 8, Issue 1 · 31 Jan 2011 · 8,060 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of U6 snRNA Transcription by PTENStephanie Cabarcas, Kounosuke Watabe, Laura SchrammProblem statement: RNA polymerase III (RNA pol III) is responsible for transcribing many of the small structural RNA molecules involved in RNA processing and protein translation, thereby regulating the growth rate of a cell. RNA pol III transcribes both gene internal (tRNA) and gene external (U6 snRNA) promoters and proper initiation by RNA polymerase III requires the transcription initiation factor … …OnLine Journal of Biological Sciences, Vol. 10, Issue 3 · 30 Sep 2010 · 8,557 accessesView PDFCite
Research ArticleOpen accessIn the abstractDetection and Localization of Anti and Pro-apoptotic mRNA Genes in Human Colorectal Cancer Using in situ RT-PCRMohd. Nazil Salleh, Boo Siaw Shi, Wan Khairuzzaman Wan Ramli et al.Problem statement: Recent studies using conventional Polymerase Chain Reaction have shown that anti-apoptotic (Cyclooxygenase-2, COX-2 and Nuclear Factor-κB, NF-κB) and proapoptotic mRNA (Bax and Bad) are involved in the tumorigenesis of colorectal cancer. The aim of this study was to localize the expression of anti and pro-apoptotic mRNA genes using Reverse Transcription in situ Polymerase Chain Reaction (RT in situ … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,446 accessesView PDFCite
Research ArticleOpen accessIn the abstractSocio-Demographic Factors Related to Oral CancerAbdoul Hossain Madani, Abdolreza Sotoodeh Jahromi, Madhurima Dikshit et al.Problem statement: The aim of this study was to identify factors related to cancer of oral cavity considering individual socio-demographic characteristics of a hospital based study in Pune. Approach: A case-control study was conducted. The cases were 350 with squamous-cell carcinoma of oral cavity diagnosed between 2005 and 2006 in Morbai, Narandia, Budharani Cancer Institute, Pune, India. Similar number of … …Journal of Social Sciences, Vol. 6, Issue 2 · 30 Jun 2010 · 8,353 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnticancer Activities of Styrylpyrone from the Leaves and Twigs of Goniothalamus maewongensis via Cell Cycle ArrestPradit Pradupsri, Chatchanok Loetchutinat, Narong Nuntasaen et al.Problem statement: Goniothalamus maewongensis is one of three new species which are found in Thailand recently. The genus goniothalamus is not only well known for the rich of styrylpyrones but also famous for the potential of biological activities, especially the cytotoxic activity against a number of human cancer cell lines. The phytochemical and biological investigations of this plant are interesting … …American Journal of Applied Sciences, Vol. 6, Issue 12 · 31 Dec 2009 · 8,195 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification and Antiproliferative Activity Evaluation of a Series of Triterpenoids Isolated from Flueggea virosa (Roxb. ex Willd.)Sod Monkodkaew, Chatchanok Loetchutinat, Narong Nuntasaen, Wilart PompimonProblem statement: Medicinal plants derived anticancer were now being subjects of many research groups especially, the secondary metabolite triterpenoids trees which had enormous potential to inspire and influence modern antiproliferative research. The study aimed to investigate the chemical constitution and their potential use as antiproliferative activity of purified compounds derived from F. virosa. Approach: The F. virosa was selected and … …American Journal of Applied Sciences, Vol. 6, Issue 10 · 30 Oct 2009 · 7,633 accessesView PDFCite
Research ArticleOpen accessIn the abstractP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,508 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effects of Recombinant Human Erythropoietin and Tamoxifen on Growth and Angiogenesis of Mammary Tumor in Sprague-Dawley RatA. K. Sairah, A. Rasedee, O. Sheikh et al.Problem statement: Erythropoietin receptor (EPOR) has been detected in breast cancer cells and speculated to be involved in cancer growth, viability and angiogenesis. This has risen suspicious that EPO administration may enhance the severity of cancer. Approach: This study was undertaken to determine the effects of rHuEPO, Tamoxifen and their combination on the growth and angiogenesis of mammary tumor. Female … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 1 · 31 Mar 2009 · 7,807 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Tumor/Immune Interface: Clinical Evidence of Cancer Immunosurveillance, Immunoediting and ImmunosubversionMatthew S. Block, Svetomir N. MarkovicProblem statement: The interactions of a malignant tumor with the patient’s immune system are dynamic, multiple and bi-directional. Approach: This article reviews the clinical evidence of the interaction of cancer with immunity with emphasis on recent developments highlighting some of the mechanisms of tumor-mediated regulation of immunity. Results: Most of the time, the immune response to a malignancy acts to … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 10,100 accessesView PDFCite
Research ArticleOpen accessIn the abstractCancer Chemotherapy and Immune RegulationJohn Barrett, Katarina Le BlancProblem statement: Chemotherapeutic drugs have been used to treat malignancy for over 50 years, but the potential of cytotoxic agents to suppress immunity and interfere with Immunosurveillance (IS) of cancer has been largely ignored. Assuming that the immune control of the cancer had a priori already failed, the effect was not considered to have a major impact on treatment outcome. … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 40,670 accessesView PDFCite