Research ArticleOpen accessIn the abstractNa,K-ATPase α Subunit-like Immunoreactive Proteins in Human Body FluidsJeng-Hsiung F. PengNa,K-ATPase was recently considered a target for breast cancer treatment since its potent inhibitors ouabain and related digitalis compounds that were reported circulating in body fluids before, were found to possess potent anti-breast cancer activity. Based on this finding, it is hypothesized that Na,K-ATPase derivatives could be circulating in the body and potential candidate biomarkers for early disease detection. Western … …American Journal of Immunology, Vol. 2, Issue 1 · 31 Mar 2006 · 6,892 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Biology of p21Waf1/Cip1 - Review PaperRenald A. Blundellp21WAF1/Cip1 belongs to the Cip/Kip family of cyclin kinase inhibitors (CKI) (p21Waf1/Cip1, p27Kip1, p57Kip1). p21Waf1/Cip1 was first described as a potent and universal inhibitor of cyclin-dependent kinases (Cdks). Two forms of functionally active p21 has been localized and described: a nuclear and a cytoplasmic forms. In this paper the structures of p21 has been described and as well as it … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 1 · 31 Mar 2006 · 7,012 accessesView PDFCite
Research ArticleOpen accessIn the abstractEssential Role of PKCδ in Apoptosis Induction of Mouse ThymocytesC. Lutz-Nicoladoni, T. Letschka, M. Leitges et al.The family of protein kinases C (PKCs) has been implicated in signal transmission leading to apoptosis induction and/or survival. These effects are cell type and tissue dependent. Numerous studies employing phorbol ester, a pleiotropic PKC activator, strongly implicated PKC in apoptosis induction of thymocytes. However, phorbol esters activate both, the conventional PKCs (PKCα, β, γ) as well as the novel … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 7,135 accessesView PDFCite