EditorialOpen accessIn the author namesChoice Meaning and Context: Two Sides of the Same Coin?Saadettin Sel, Joachim Storsberg, Mark A. Brown, Christian SchmidtThe human intellect is a powerful instrument to be applied to problems. Expressed differently, sharpening one’s acumen by regular exposure to conundra can be likened to exercising a muscle or refining a tool such as creating brushes to suit certain tasks. Such applications hinge on a reasonable understanding of a given problem and the presentation of opposing viewpoints of the … …American Journal of Immunology, Vol. 13, Issue 2 · 24 May 2017 · 6,923 accessesView PDFCite
EditorialOpen accessIn the author namesWhere the Future is Being Made TodayMark A. Brown, Joachim Storsberg, Christian SchmidtGrowing up, I was fascinated by The Muppet Show and the adventures of Dr. Bunsen Honeydew and his assistant Beaker. Apparently, my feelings were not unique because Muppet characters are used to ease tensions associated with education about clinical interventions (Ramsay, 2014; Rohn, 2007). Yet the opening phrase 'Where the future is being made today' has, in my opinion, summed … …American Journal of Immunology, Vol. 12, Issue 2 · 28 Jun 2016 · 7,425 accessesView PDFCite
EditorialOpen accessIn the author namesAn Immunological Argument for One HealthMark Brown et al.Human exposure to heavy metals is associated with higher rates of immunological deficiencies, autoimmunity, and cancer. Chronic exposure to lead contributes to abnormalities in immunomodulation while cadmium is linked to breast, prostate, and lung cancers. Prenatal exposure to these metals impacts both the development and function of immune cells. The concept of one health underscores the importance of the interface … …American Journal of Immunology, Vol. 18, Issue 1 · 3 Feb 2023 · 9,822 accessesView PDFCite
Research NotesOpen accessIn the author namesIndividualizing Periods of Commercial Exclusivity to Control Pricing for Drugs and BiologicsCallie M. Blase, Brandon K. Rouault, Maia B. Zoller et al.The pricing for immunologic agents and antibody-based therapeutics has increased precipitously in recent years. Among the key contributors to price hikes is the static practice of granting commercial exclusivity to innovator drugs and biologics. Herein, we present a mechanism for individualizing periods of commercial exclusivity to control pricing for drugs and biologics. …American Journal of Immunology, Vol. 15, Issue 1 · 13 Sep 2019 · 7,011 accessesView PDFCite
Research NotesOpen accessIn the author namesMethods for Universal Authentication of Medical DevicesMark A. Brown, Ilham Alshiraihi, Callie Blase et al.The need for effective means of authentication of medical devices has increased with the growing number of falsified in vitro diagnostics and devices being introduced across world markets. Such substandard products result in negative consequences ranging from harm to patients and/or failure to impart the desired clinical outcomes to a loss of public trust in healthcare providers and regulatory agencies. … …American Journal of Immunology, Vol. 15, Issue 1 · 17 Jun 2019 · 7,355 accessesView PDFCite
Research ArticleOpen accessIn the author namesThe Arid3a Transcription Factor Rescues Natural and RAS-V12-Induced Senescence Via a Rb-Dependent PathwayChristian Schmidt, Dongkyoon Kim, Shawn Mathur et al.Primary cells are protected against oncogenic events by undergoing premature cellular senescence—an irreversible cell cycle arrest activated by mitogenic signaling as well as by overexpression of tumor suppressors, including p16INK4A, p53 and PML. In the human, downregulation of Dril1/E2F-BP1, a transcriptional regulator of E2F, promotes PML-dependent premature senescence and bypass of ant-iproliferative signaling by p19Arf/p53/p21Cip1 and p16INK4a to prevent both … …American Journal of Immunology, Vol. 13, Issue 4 · 4 Nov 2017 · 8,396 accessesView PDFCite
Research NotesOpen accessIn the author namesFunctionalization Strategies for Antibodies: Lessons LearnedChristian Schmidt, Martin Geyer, Jörg Bohrisch et al.Precious little is known about useful functionalization strategies of antibodies that will not impair either reactivity or specificity of this valuable reagent. We used an experimental approach to demonstrate our own experience with published protocols. The conjugates obtained were then tested with regard to their performance against commercially available detection kits. Our results are then viewed in light of published … …American Journal of Immunology, Vol. 13, Issue 2 · 4 May 2017 · 7,592 accessesView PDFCite
EditorialOpen accessIn the author namesWhat You See Is What You GetSaadettin Sel, Mark A. Brown, Joachim Storsberg, Christian SchmidtThe recognition and neutralization of invading pathogens by the human immune system is designed to protect the organism. Sometimes, the checks and balances in place securing a tightly controlled immune surveillance of privileged sites are lifted in order to ensure survival of the individual at the cost of losing the functionality of an organ. Here, we use choice areas to … …American Journal of Immunology, Vol. 12, Issue 3 · 29 Sep 2016 · 6,975 accessesView PDFCite