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8 results for “Manu Chaudhary”
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Research ArticleOpen accessIn the author namesEvaluation of Different Drugs in Down-Regulation of Efflux Pump Genes expression in Methicillin-Resistant Staphylococcus aureus StrainsManu Chaudhary, Santosh Kumar Patnaik, Anurag PayasiAntimicrobial resistance caused by efflux systems is not widely studied in Staphylococcus aureus. In the present study, prevalence of NorA and NorB efflux pumps was studied in thirteen Methicillin-Resistant Staphylococcus aureus (MRSA) strains using a pair of primers with Polymerase Chain Reaction (PCR). Antibiotic susceptibility study in NorA and NorB efflux positive isolates was carried out according to the Clinical … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 7 Jan 2015 · 7,454 accessesView PDFCite
Research ArticleOpen accessIn the author namesInhibition of Panton-Valentine Leukocidin Toxin Induced Neutrophil Cell Lysis by Vancoplus in Methicillin-Resistant Staphylococcus Aureus InfectionsManu Chaudhary, Santosh Kumar Patnaik, Anurag PayasiPantone Valentine Leukocidin (PVL) is a cytotoxin associated with virulence of Methicillin-Resistant Staphylococcus aureus (MRSA). This study was undertaken to analyze the prevalence of PVL among MRSA strains and to study the effect of adjuvants (L-lysine, L-arginine, Ethylenediamine Tetraacetic Acid (EDTA) as well as drugs on PVL induced neutrophil cell lysis. Further, in vitro activity of Vancoplus, vancomycin, linezolid, teicoplanin … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 20 Dec 2014 · 7,110 accessesView PDFCite
Research ArticleOpen accessIn the author namesEMERGING METRONIDAZOLE RESISTANCE IN ANAEROBES AND MAPPING THEIR SUSCEPTIBILITY BEHAVIOURManu Chaudhary, Anurag PayasiIn the present study, anaerobic clinical isolates of Bacteroides fragilis, Escherichia coli, Staphylococcus aureus and Yersinia enterocolitica were obtained from different clinical specimens and were subjected to molecular typing to detect the gene encoding metronidazole resistance in these isolates. Subsequently, antibacterial activity of drugs was tested against the selected clinical isolates. A total of 53 clinical isolates involving 18 obligate … …American Journal of Infectious Diseases, Vol. 10, Issue 2 · 12 Apr 2014 · 9,196 accessesView PDFCite
Research ArticleOpen accessIn the author namesINHIBITORY ACTIVITY OF POTENTOX AGAINST DNA GYRASE OF ENTEROBACTERIACEAEManu Chaudhary, Anurag PayasiDNA gyrase, a type II topoisomerase catalyzes the supercoiling of relaxed closed circular DNA. In this report we evaluated the in vitro inhibitory effect of non antibiotic adjuvant compounds disodium edetate and sodium citrate against supercoiling activity of bacterial DNA gyrase. Further, we assessed the effect of different drugs alone and in combination with one or more adjuvants in overcoming … …American Journal of Infectious Diseases, Vol. 10, Issue 1 · 8 Feb 2014 · 7,291 accessesView PDFCite
Research ArticleOpen accessIn the author namesSYNERGY OF A NOVEL ANTIBIOTIC ADJUVANT ENTITY AGAINST MULTI DRUG RESISTANT ENTEROBACTERIACEAEManu Chaudhary, Anurag PayasiIn the present investigation, we investigated the in vitro interaction of ceftriaxone plus sulbactam with disodium edetate, a Non Antibiotic Adjuvant (NAA) against selected clinical isolates and in vitro susceptibility studies were also performed. The isolates were tested against a range of ratios of ceftriaxone and sulbactam using a microdilution checkerboard method. Having determined the appropriate ratios of ceftriaxone plus … …American Journal of Infectious Diseases, Vol. 9, Issue 3 · 1 Nov 2013 · 7,419 accessesView PDFCite
Research ArticleOpen accessIn the author namesPrevalence of Heterogeneous Glycopeptide Intermediate Resistance in Methicillin-Resistant Staphylococcus aureusManu Chaudhary, Anurag PayasiMultidrug resistant Methicillin-Resistant Staphylococcus Aureus (MRSA) is a major cause of nosocomial and community acquired infections and is on the rise. The aim of this investigation was to explore the prevalence of MRSA and heterogeneous Glycopeptide Intermediate Staphylococcus Aureus (hGISA) in various clinical samples, to investigate the various antibiotic resistant determinant genes among these strains collected from north and west … …American Journal of Infectious Diseases, Vol. 9, Issue 3 · 4 Sep 2013 · 7,203 accessesView PDFCite
Research ArticleOpen accessIn the author namesDevelopment and Validation of High Performance Liquid Chromatographic Method for the Simultaneous Determination of Ceftazidime and Sulbactam in Spiked Plasma and Combined Dosage form-ZydotamMasoom Raza Siddiqui, Abu Tariq, Manu Chaudhary et al.Problem statement: To develop a sensitive method to determine simultaneously ceftizidime and sulbactam in spiked plasma and combined formulation. Approach: In this study an isocratic High performance liquid chromatographic method with UV detection at 230 nm was described for simultaneous determination of Ceftazidime and sulbactam sodium in plasma and combined dosage form. Chromatographic separation of two drugs was achieved on … …American Journal of Applied Sciences, Vol. 6, Issue 10 · 31 Oct 2009 · 7,675 accessesView PDFCite