Research ArticleOpen accessIn the author namesThe Arid3a Transcription Factor Rescues Natural and RAS-V12-Induced Senescence Via a Rb-Dependent PathwayChristian Schmidt, Dongkyoon Kim, Shawn Mathur et al.Primary cells are protected against oncogenic events by undergoing premature cellular senescence—an irreversible cell cycle arrest activated by mitogenic signaling as well as by overexpression of tumor suppressors, including p16INK4A, p53 and PML. In the human, downregulation of Dril1/E2F-BP1, a transcriptional regulator of E2F, promotes PML-dependent premature senescence and bypass of ant-iproliferative signaling by p19Arf/p53/p21Cip1 and p16INK4a to prevent both … …American Journal of Immunology, Vol. 13, Issue 4 · 4 Nov 2017 · 8,397 accessesView PDFCite
Research ArticleOpen accessIn the abstractTAGN-IDC: Implicit Discrete Constraints for Tsunami Aware Graph Neural Networks in Spatial Evacuation RoutingSularno, Wendi Boy, Putri Anggraini et al.Tsunami evacuation route requires rapid identification of safe evacuation paths under dynamically changing hazard conditions. A major challenge is incorporating hard binary road-blockage constraints caused by tsunami inundation while maintaining end-to-end differentiability for deep learning models. Existing approaches commonly rely on continuous relaxations or stochastic sampling techniques, which either compromise physical feasibility or increase computational complexity. This study proposes the … …Journal of Computer Science, Vol. 22, Issue 9 · 24 Sep 2026 · 711 accessesView PDFCite
EditorialOpen accessIn the abstractWhere the Future is Being Made TodayMark A. Brown, Joachim Storsberg, Christian SchmidtGrowing up, I was fascinated by The Muppet Show and the adventures of Dr. Bunsen Honeydew and his assistant Beaker. Apparently, my feelings were not unique because Muppet characters are used to ease tensions associated with education about clinical interventions (Ramsay, 2014; Rohn, 2007). Yet the opening phrase 'Where the future is being made today' has, in my opinion, summed … …American Journal of Immunology, Vol. 12, Issue 2 · 28 Jun 2016 · 7,427 accessesView PDFCite