Microwave Assisted Regioselective Synthesis and Biological Evaluation of Pyrano[2,3-c]Pyridine Derivatives Utilizing DMAP as a Catalyst

Regioselective facile production of pyrano[2,3-c]pyridine through multicomponent reaction of aromatic aldehydes, ethyl cyano acetate or malononitrile and C-H activated compound of 3-hydroxy picolinic acid in the occurrence of smaller amount of DMAP catalyst utilizing microwave apparatus, which is green and simple environmentally with high yield, recyclability catalyst. Totally the products were partitioned for antimicrobiogical action; it was detected that were active in contrast to S. pneumonia, E. coli and Candida albicans such as equated to typical drugs. Compounds of pyrano[2,3-c]pyridine-8-carboxylic acid derivatives 4i, 4e, 4p and 4p demonstrated effective development inhibitory activities. Additionally, the manufactured products were partitioned for in vitro-antioxidant action by DPPH analysis. Products of pyrano[2,3-c]pyridine 4o and 4p were worthy free radical scavenging action through IC₅₀ values of 252.52 and 223.2 µM; respectively.