Relation between Autoimmunity Chronic Urticaria and the Levels of Plasma Prothrombin F₁₊₂

A number of recent epidemiologic and experimental studies have enhanced our knowledge of the etiology and pathogenesis of chronic urticaria (CU), a disease that imposes profound impairment on patient's quality of life. Our study was performed to explore the relation between autoimmunity (CU) and the levels of plasma prothrombin F₁₊₂. Thirty four (CU) patients with positive autologous serum skin test (APST) their F₁₊₂ were measured by ELISA at pre and post therapy. The levels of F₁₊₂ in autoimmunity (CU) patients have been decreased obviously after treatment (3.34±2.87vs 0.94±0.58, p<0.001). Before treatment, the levels of treatment group was significantly higher than that of control group (3.34±2.87vs 0.72±0.36,p<0.001). After treatment, they have no significant difference (0.94±0.58vs 0.72±0.36, p>0.05).