Volume 5, Issue 2 (2015) | Current Research in Biostatistics

Adaptive Superiority and Noninferiority Trial Design with Paired Binary Data

Mark Chang — 2015-09-07

Current Research in Biostatistics, Published online: 7 September 2015; doi:10.3844/amjbsp.2015.52.60

Non-inferiority of a diagnostic test to the standard is a common issue in medical research. For instance, we may be interested in determining if a new diagnostic test is noninferior to the standard re...

Trial Design and Analysis with Incomplete Paired Data

Mark Chang — 2015-11-12

Current Research in Biostatistics, Published online: 12 November 2015; doi:10.3844/amjbsp.2015.61.68

For a clinical trial design with paired data, it often involves missing observations. In such a case, the data from the trial become a mixture of paired and unpaired data. A commonly used approach for...

Interface between the Ratio β with Area Under the ROC Curve and Kullback-Leibler Divergence Under the Combination of Half Normal and Rayleigh Distributions

Saebugari Balaswamy — 2015-11-12

Current Research in Biostatistics, Published online: 12 November 2015; doi:10.3844/amjbsp.2015.69.77

Classifying objects/individuals is common problem of interest. Receiver Operating Characteristic (ROC) curve is one such tool which helps in classifying the objects/individuals into one of the two kno...