Volume 1, Issue 1 (2012) | Current Research in Bioinformatics

A Sequence Based Validation of Gene Expression Microarray Data

Gerhard G. Thallinger — 2012-01-19

Current Research in Bioinformatics, Published online: 19 January 2012; doi:10.3844/ajbsp.2012.1.9

Problem statement: Quantitative Reverse Transcription PCR (RT-qPCR) is often used to validate microarray data. Previous studies show different levels of correlation, without further investigation of i...

Bioinformatics-Assisted Microbiological Research: Tasks, Developments and Upcoming Challenges

Dhananjaya P. Singh — 2012-01-23

Current Research in Bioinformatics, Published online: 23 January 2012; doi:10.3844/ajbsp.2012.10.19

Problem statement: Bioinformatics in the present day microbiological research is an inevitable subject area that encompasses biological resources and high end computational skills to unravel the coded...

Bayesian Determination of Disease Associated Differences in Haplotype Blocks

Ivan Kozyryev — 2012-02-14

Current Research in Bioinformatics, Published online: 14 February 2012; doi:10.3844/ajbsp.2012.20.29

Problem statement: While experimental ascertainment of haplotype blocks in the genome-scale case-control studies is expensive, accurate computational phasing is still a daunting task for bioinformatic...

Use of Enterobacterial Repetitive Intergenic Consensus PCR in Detecting Target(s) of Hapalindole-T, From a Cyanobacterium, in Escherichia Coli: In Silico Validation

Manoj K. Tripathi — 2012-03-03

Current Research in Bioinformatics, Published online: 3 March 2012; doi:10.3844/ajbsp.2012.30.40

Problem statement: Identification of newer biomolecule as well as targets are a rising concern because of increasing drug resistance in bacteria. We have isolated a broad spectrum antibiotic biomolecu...

Providing Collaborative Algorithms Support for Personal Health Care

Vladimir Trajkovik — 2012-03-08

Current Research in Bioinformatics, Published online: 8 March 2012; doi:10.3844/ajbsp.2012.41.49

Problem statement: Today, there is a growing interest towards the adoption of novel technology in the field of medical monitoring and personal health care systems in general. This is especially case w...

Using Threads to Overcome Synchronization Delays in Parallel Multiple Progressive Alignment Algorithms

Evandro A. Marucci — 2012-03-08

Current Research in Bioinformatics, Published online: 8 March 2012; doi:10.3844/ajbsp.2012.50.63

Problem statement: The parallelization of multiple progressive alignment algorithms is a difficult task. All known methods have strong bottlenecks resulting from synchronization delays. This is even m...

An Optimal Approach for Medical Image Analysis

J. Umamaheswari — 2012-06-06

Current Research in Bioinformatics, Published online: 6 June 2012; doi:10.3844/ajbsp.2012.64.69

Problem statement: Image segmentation is the process that subdivides an image into its constituent parts and extracts the objects. It is one of the most critical tasks in automatic image analysis beca...

Bayesian Exploration of Multilocus Interactions on the Genome-Wide Scale

Ivan Kozyryev — 2012-07-02

Current Research in Bioinformatics, Published online: 2 July 2012; doi:10.3844/ajbsp.2012.70.78

Problem statement: Recent technological and scientific advances propelled the field of Genome-Wide Association Study (GWAS), which promises to be instrumental in linking many common complex diseases t...