Volume 8, Issue 1 (2019) | Current Research in Bioinformatics

ONCObc-ST: An Improved Clinical Reasoning Algorithm Based on Select and Test (ST) Algorithm for Diagnosing Breast Cancer

Olaide Nathaniel Oyelade — 2019-04-15

Current Research in Bioinformatics, Published online: 15 April 2019; doi:10.3844/ajbsp.2019.1.13

The need for an accurate reasoning algorithm is usually necessitated by the sensitivity of domain of (medicine as example) application of such algorithms. Most reasoning algorithms for medical diagnos...

Comparison of IncL/M Plasmids Using the Neighbor-Joining Method on Basis repA and excA Genes

Touati Abdelaziz — 2020-02-27

Current Research in Bioinformatics, Published online: 27 February 2020; doi:10.3844/ajbsp.2019.14.17

The aim of this study is to make comparison of IncL/M groups on basis of two genes candidates’ repA and excA genes. The sequences of 27 plasmids were compared using the neighbor-joining method. This...

Molecular Docking of New Active Compounds Towards the Acetylcholinesterase Enzyme

Lemaoui Tarek — 2020-02-27

Current Research in Bioinformatics, Published online: 27 February 2020; doi:10.3844/ajbsp.2019.18.20

Molecular docking is a key instrument in structural molecular biology and computer-assisted drug design. The objective of ligand-protein docking is to expect the main binding mode(s) of a ligand with ...

The Development of New Molecules Having Antiemetic Activity Using Molecular Modeling

Khalil Errahmane Kanouni — 2020-02-27

Current Research in Bioinformatics, Published online: 27 February 2020; doi:10.3844/ajbsp.2019.21.28

The solubility of a drug in water or in the blood represents the most desired parameter in medicine. Our aim is to obtain molecules with properties more effective than those of metoclopramide. In this...

The Relevance of Bioinformatic Tools in the Study of Polymorphisms of the B4GALNT2 Gene and its Association with Cancer

Eddaikra Atika — 2020-02-27

Current Research in Bioinformatics, Published online: 27 February 2020; doi:10.3844/ajbsp.2019.29.33

The human gene B4GALNT2 encodes an enzyme (β1,4-N-acetylgalactosaminyltransferase II) that controls the expression of the blood group Sda carbohydrate’s antigen. This gene is located in position 17...

Highlight of New Phosphodiesterase 10A Inhibitors Using Molecular Docking

Halla Belhoula — 2020-02-27

Current Research in Bioinformatics, Published online: 27 February 2020; doi:10.3844/ajbsp.2019.34.37

Phosphodiesterase 10A (PDE 10A) is an effective therapeutic approach for treatments of Schizophrenia (SCZ). In order to identify in silico new potent PDE 10A inhibitors, molecular docking approach was...

In silico Assessment of the Arg85Trp Glucokinase Mutation Effects

Faiza Bouldjennet — 2020-02-27

Current Research in Bioinformatics, Published online: 27 February 2020; doi:10.3844/ajbsp.2019.38.41

Maturity Onset Diabetes of the Young (MODY) is a heterogeneous group of autosomal dominantly inherited, young-onset β-cell disorders that account for approximately 2% of non-insulin-dependent diabeti...

In Silico Cholinesterase and Monoamine Oxidase Inhibitory Activities of Perillaldehyde and D-Limonene, Main Compounds of Essential Oil of Algerian Ammodaucus leucotrichus

Nesrine Sadaoui-Smadhi — 2020-02-28

Current Research in Bioinformatics, Published online: 28 February 2020; doi:10.3844/ajbsp.2019.42.45

In a continuation of our previous work for the exploration of novel enzyme inhibitors, molecular modeling was used to inspect the binding mode of perillaldehyde and D-limonene, the major compounds of ...

Diversity of Culturable Halophilic Archaea and Bacteria from Chott Tinsilt and El Malah Salt-Lake in Algeria

Akmoussi-Toumi Siham — 2020-02-28

Current Research in Bioinformatics, Published online: 28 February 2020; doi:10.3844/ajbsp.2019.46.54

At the limits of life, hyper-saline aquatic ecosystems; Chott and Sebkha are a model of choice of extreme environments, housing a halophilic microflora that had to adapt to these conditions. In Algeri...

Phylogeny and Molecular Study of Some Entomopathogenic Rhizobacteria Isolated from Two Regions in Algeria

Oulebsir-Mohandkaci Hakima — 2020-03-02

Current Research in Bioinformatics, Published online: 2 March 2020; doi:10.3844/ajbsp.2019.55.61

The use of bacteria in the control of insect pests is a form of biological control whose practice is still not widespread. It is in this context that the present work falls. It concerns the isolation,...

QSAR Modeling of Thirty Active Compounds for the Inhibition of the Acetylcholinesterase Enzyme

Nour El Houda Hammoudi — 2020-03-02

Current Research in Bioinformatics, Published online: 2 March 2020; doi:10.3844/ajbsp.2019.62.65

This work aims at developing a reliable and predictive QSAR model which allows, on one hand, an exploration of the main molecular descriptors responsible for the inhibitory activity towards the Acetyl...