Volume 9, Issue 1 (2014) | American Journal of Pharmacology and Toxicology

HYPOGLYCEMIC, HEPATO-RENAL AND ANTIOXIDANT POTENTIAL EFFECTS OF CHAMOMILE RECUTITA FLOWERS ETHANOLIC EXTRACT IN STREPTOZOTOCIN-DIABETIC RATS

Hassan Al-Musa — 2013-12-09

American Journal of Pharmacology and Toxicology, Published online: 9 December 2013; doi:10.3844/ajptsp.2014.1.12

This study was undertaken to evaluate the hypoglycemic and hepatorenal protective effect of ethanolic extract of Chamomile recutita flowers in streptozotocin-Diabetic Rats. Before the beginning of the...

REMEDIAL EFFECTS OF VITAMIN E AND L-ARGININE ON PERIPHERAL NEUROPATHY IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Ismaeel Bin-Jaliah — 2013-12-23

American Journal of Pharmacology and Toxicology, Published online: 23 December 2013; doi:10.3844/ajptsp.2014.13.23

It was shown that hyperglycemia in diabetic patients is the main factor of diabetic peripheral neuropathies. Various pathways related to oxidative stress, vascular defect and defective endothelium dep...

IN VIVO ANTIPLASMODIAL ACTIVITY AND ACUTE TOXICITY OF STANDARDIZED EXTRACT OF EURYCOMA LONGIFOLIA JACK. ROOT TRADITIONALLY USED TO TREAT MALARIA

Eti Nurwening Sholikhah — 2013-12-27

American Journal of Pharmacology and Toxicology, Published online: 27 December 2013; doi:10.3844/ajptsp.2014.24.28

A series of studies has been conducted to prove the Eurycoma longifolia Jack. root as an antimalarial. However, the in vivo antiplasmodial activity of E. longifolia Jack. root standardized extract and...

POTENTIAL AMELIORATIVE ROLE OF N-ACETYLCYSTEINE AGAINST TESTICULAR DYSFUNCTION INDUCED BY TITANIUM DIOXIDE IN MALE ALBINO RATS

Ahmed Farag El-Kirdasy — 2013-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2013; doi:10.3844/ajptsp.2014.29.38

In this study, we examined the ameliorative action of N-Acetylcysteine (NAC) against Titanium Dioxide (TiO2) induced testicular degeneration in albino rats. Adult male albino rats were given saline as...

APIGENIN CAUSES BIOCHEMICAL MODULATION, GLUT4 AND CD38 ALTERATIONS TO IMPROVE DIABETES AND TO PROTECT DAMAGES OF SOME VITAL ORGANS IN EXPERIMENTAL DIABETES

Chowdhury Mobaswar Hossain — 2014-01-13

American Journal of Pharmacology and Toxicology, Published online: 13 January 2014; doi:10.3844/ajptsp.2014.39.52

Diabetes mellitus gradually leads to dysfunction and failure of some vital organs specially the eyes, kidneys, pancreas, brain, heart, liver and lungs. The study was aimed to evaluate the antidiabetic...

ABSENCE OF VISIBLE TOXIC EFFECTS ACCOMPANYING THE SHORT-TERM ADMINISTRATION OF AN AQUEOUS EXTRACT OF ALLIUM SATIVA LINN. IN MALE SPRAGUE-DAWLEY RATS

J. Asiedu-Gyekye Isaac — 2014-01-30

American Journal of Pharmacology and Toxicology, Published online: 30 January 2014; doi:10.3844/ajptsp.2014.53.67

Allium sativum is cultivated in the northern part of Ghana and has gained widespread use as chemoprotective, in curing hypertension, impotence and erectile dysfunction. The multipurpose use together w...

RISK-BENEFIT ANALYSIS AND RISK MINIMIZATION OF QUINAPRIL: A REVIEW

Anjo Sunny — 2014-02-12

American Journal of Pharmacology and Toxicology, Published online: 12 February 2014; doi:10.3844/ajptsp.2014.68.74

The purpose of this review is to give the readers an insight about the risks and benefits of ’quinapril’, a potent Angiotensin Converting Enzyme Inhibitor (ACEI). Quinapril is a highly effective n...

EFFECT OF DIMETHOATE (AN ORGANOPHOSPHATE INSECTICIDE) ON THE REPRODUCTIVE SYSTEM AND FERTILITY OF ADULT MALE RAT

Ferdinand Ngoula — 2014-02-13

American Journal of Pharmacology and Toxicology, Published online: 13 February 2014; doi:10.3844/ajptsp.2014.75.83

The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dimethoate is widely used as a potent pesticide in many countries and has been sho...

QUERCETIN AMELIORATES DIABETIC NEPHROPATHY IN RATS VIA MODULATION OF RENAL NA⁺, K⁺-ATPASE EXPRESSION AND OXIDATIVE STRESS

Salah O. Bashir — 2014-02-14

American Journal of Pharmacology and Toxicology, Published online: 14 February 2014; doi:10.3844/ajptsp.2014.84.95

Diabetic Nephropathy (DN) is one of most prevalent complications of Diabetes Mellitus (DM), therefore prevention of its development is a important field for researches. Quercetin is a plant flavenoid ...

AMELIORATIVE EFFECT OF HIBISCUS SABDARIFFA LINN ON SUBCHRONIC CHLORPYRIFOS-INDUCED ALTERATIONS IN SEX AND THYROID HORMONES IN MALE WISTAR RATS

Shittu Muftau — 2014-02-20

American Journal of Pharmacology and Toxicology, Published online: 20 February 2014; doi:10.3844/ajptsp.2014.96.106

Studies have shown that Chlorpyrifos (CPF), an Organophosphate (OP) insecticide alters both sex and thyroid hormones. Apart from inhibiting Acetylcholinesterase (AChE) activity, CPF has been shown to ...