Volume 6, Issue 3 (2011) | American Journal of Pharmacology and Toxicology

Mechanisms of Anti-Cancer Effects of Vernonia amygdalina Leaf Extract

Utoh-Nedosa Uchechukwu Anastasia — 2011-10-26

American Journal of Pharmacology and Toxicology, Published online: 26 October 2011; doi:10.3844/ajptsp.2011.76.79

Problem statement: Vernonia amygdalina (V. amygdalina) has been shown to have cancer cell inhibition and cytotoxic effects. Approach: This study discusses the multi-faceted and multi-linked mechanisms...

Slow Fungal Hydrolysis of Complex Sugar is Responsible for the Use of Sugar as Vehicle for Antifungal Drugs

Nedosa Ikenna Valentine — 2011-11-02

American Journal of Pharmacology and Toxicology, Published online: 2 November 2011; doi:10.3844/ajptsp.2011.80.83

Problem statement: Aspergillus niger strain (UUF 9202) significantly reduced the dormancy period and boosted aggregate germination time in seeds of Tetrapleura tetraptera by 42% in 32 days and produce...

Effect of Hydro-Alcoholic Extract of Cucurbita Maxima, Fruit Juice and Glibenclamide on Blood Glucose in Diabetic Rats

V. K. Lal — 2011-11-26

American Journal of Pharmacology and Toxicology, Published online: 26 November 2011; doi:10.3844/ajptsp.2011.84.87

Problem statement: Cucurbita maxima has been used traditionally in Mexico, China and India as antidiabetic agents. Approach: The present study was to evaluate the hypoglycemic activity of fruit juice ...

Effect of Intrahippocampal γ Aminobutyrate B Receptor on Pain Sensitivity during Estrous Cycle

Mahnaz Taherianfard — 2011-11-26

American Journal of Pharmacology and Toxicology, Published online: 26 November 2011; doi:10.3844/ajptsp.2011.88.95

Problem statement: There is a relationship between sexual hormones and pain sensitivity and also a role for hippocampal GABAB receptor in nociception. Therefore, the aim of the present investigation w...

Toxicological Evaluation of Aspilia Africana Leaf Extracts in Mice

O. O.K. Oko — 2011-11-28

American Journal of Pharmacology and Toxicology, Published online: 28 November 2011; doi:10.3844/ajptsp.2011.96.101

Problem statement: The degree of toxicity of crude extracts of Aspilia Africana (Bush marigold) leaf on the basis of routes and dosages of administration were investigated. 204 healthy, male Swiss alb...