Volume 5, Issue 4 (2010) | American Journal of Pharmacology and Toxicology

Toxicity evaluation of yoyo 'cleanser' bitters and fields Swedish bitters herbal preparations following sub-chronic administration in rats

Martins Ekor — 2011-06-13

American Journal of Pharmacology and Toxicology, Published online: 13 June 2011; doi:10.3844/ajptsp.2010.159.166

Problem statement: Owing to numerous adverse effects of most orthodox pharmaceuticals, the use of herbal remedies in treatment and prevention of diseases is gaining much attention, especially in devel...

Evaluation of in vivo Antioxidant and Hepatoprotective Activity of Portulaca oleracea L. against Paracetamol-Induced Liver Toxicity in Male Rats

Mohamed H. Ahmida — 2011-06-13

American Journal of Pharmacology and Toxicology, Published online: 13 June 2011; doi:10.3844/ajptsp.2010.167.176

Problem statement: Oxidative stress plays a major role in paracetamol induced hepatotoxicity. Portulaca oleracea (P.O.) has been shown to exhibit antioxidant properties. The present study aimed to i...

Effect of Sodium Fluoride on Cancellous Bone Defect Healing in Rats

Ghafour Mousavi — 2011-06-13

American Journal of Pharmacology and Toxicology, Published online: 13 June 2011; doi:10.3844/ajptsp.2010.177.182

Problem statement: The purpose of this study was to histopathology and biomechanics evaluate the effect of sodium fluoride on cancellous bone defect healing in rat model. Approach: The experiment wa...

Uncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel Mechanism

Claudia Maturo — 2011-06-13

American Journal of Pharmacology and Toxicology, Published online: 13 June 2011; doi:10.3844/ajptsp.2010.183.208

Problem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK...