Volume 4, Issue 4 (2009) | American Journal of Pharmacology and Toxicology

Studies on Wound Healing and Antiulcer Activities of Extract of Aerial Parts of Phyllanthus niruri L. (Euphorbiaceae)

C. O. Okoli — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.118.126

Problem statement: Phyllanthus niruri is widely used in many parts of the world to manage a wide range of diseases. As part of efforts to elucidate its pharmacological activities and hence medicinal p...

Potent Antielastase and Antityrosinase Activities of Astilbe chinensis

Seung-Hun Lee — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.127.129

Problem statement: In the current scenario, photo-aging is a major problem causing skin wrinkling and hyperpigmentation. Therefore, elastase and tyrosinase inhibitors play an important role in the tre...

Reproductive Toxicology of Tartrazine (FD and C Yellow No. 5) in Swiss Albino Mice

N. Mehedi — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.130.135

Problem statement: Tartrazine (FD and C Yellow No. 5) is an orange-colored widely used in food products, drugs and cosmetics. This color has a potential toxicological risk. The current study evaluated...

Camel's Milk Protects Against Cadmium Chloride-Induced Hypocromic Microcytic Anemia and Oxidative Stress in Red Blood Cells of White Albino Rats

Mohammad Dallak — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.136.143

Problem statement: Cadmium is a heavy metal of wide occupational and environmental contamination. In recent years, however, Cadmium has been implicated in the pathogenesis of several clinical disorder...

Assessment of the Mutagenicity of Some Pharmaceutical Effluents

A. Akintonwa — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.144.150

Problem statement: The pharmaceutical industry is a major contributor to industrial wastes globally. Effluents from this industry are usually discharged into the environment and when not properly hand...

The Efficacy of Karkadeh Tea in Controlling Post-Prandial Blood Glucose Levels

Adrian Paul Harrison — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.151.157

Problem statement: Increasing interest from the general public to use herbal remedies, exposes a considerable need to document ancient medical practices, as well as to investigate the efficacy of “a...

Involvement of Microsomal Na⁺/K⁺ ATPase Activity in the Mechanism of Action of Dopaminergic D2 Receptors

Abdulrahim Abu-Jayyab — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.158.164

Problem statement: Our previous research has shown that mitochondrial ATPase may have a role in the action of dopaminergic D2 receptors. It is therefore, thought of interest to investigate the effect ...

A Comparative Study between Abdominal and Laparoscopic Diathermy in Evaluation of Ovulatory Response in Women with Polycystic Ovary Syndrome

Nabila K. Yaaqoub — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.165.168

Problem statement: To compare the effects of both abdominal and laparoscopic diathermy (PCOS) on the ovulatory process. Design: Prospective study. Setting: Tikrit Teaching Hospital, Iraq. Approach: A ...

Evaluation of the Toxic Effects of Dihydroartemisinin on the Vital Organs of Wistar Albino Rats

A. U. Utoh-Nedosa — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.169.173

Problem statement: The current surge in the use of Artemisinin based Combination Therapy (ACT) in the treatment of falciparium resistant malaria in the tropics and the potentials of Dihydroartemisinin...

The "Forgotten Side Effect" of Thiazides

Arnon Blum — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.174.176

Problem statement: Thiazide diuretics are derived from benzodiazines. They inhibit Na+/Cl- re-absorption from the distal convoluted tubules in the kidneys by blocking the thiazide-sensitive Na+/Cl- sy...

Cryptolepine Provokes Changes in the Expression of Cell Cycle Proteins in Growing Cells

Charles Ansah — 2009-12-31

American Journal of Pharmacology and Toxicology, Published online: 31 December 2009; doi:10.3844/ajptsp.2009.177.185

Problem statement: Cryptolepine, the antimalarial plant alkaloid is cytotoxic to mammalian cells, but there is rather little understanding of the possible mechanisms involved in the cell-kill action o...