Volume 2, Issue 2 (2007) | American Journal of Pharmacology and Toxicology

Evaluation of Local Injection of 0.5% Bupivacaine + 1/200000 Epinephrine for Post Tonsillectomy Pain Reduction

Keramat Mozafarinia — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.26.29

To determine the effectiveness of postoperative local infiltration of Bupivacaine in decreasing post tonsillectomy pain. A double blind randomized clinical trail was conducted. Treatment group was adm...

CPI-1189 Protects against TNBS-induced Colitis in a Rodent Model

Beverley Greenwood-Van Meerveld — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.30.38

Nitrone-related therapeutics (NRTs) represents a new class of molecules that may be effective in treating inflammatory conditions. The goal of this study was to examine the effect of CPI-1189 in a rat...

In Vitro Studies on the Effect of Phototoxicity of A New Photosensitizer Extracted from Flowers and Aerial Parts of Cichorium pumilum

M-Ali H. Al-Akhras — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.39.45

New photosensitizers have been extracted from the flowers and aerial parts of the Cichorium pumilum Jacq (chicory). Chicory grows naturally in local wild areas and is known to cause quick death of onl...

In Vivo Anti-malarial Tests of Nigella sativa (Black Seed) Different Extracts

H.A.A. Abdulelah — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.46.50

Nigella sativa (black seed) seeds have been used as a traditional medicine for the treatment of a variety of sicknesses including parasitic diseases. Intraperitoneal and oral administrations of ethano...

Naloxone benzoylhydrazone activates Extracellular Signal-Regulated Protein Kinases and modulates Nociceptin Opioid Peptide Receptor activity

Deepak R. Thakker — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.51.59

Naloxone benzoylhydrazone (NalBzoH) is often used as a nociceptin opioid peptide (NOP) receptor antagonist. However, NalBzoH is also a mixed μ antagonist/κ and δ opioid agonist and its actions at t...

Zonisamide: The Arizona Experience

K.J. Oommen — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.60.64

Zonisamide (ZNS) is a new antiepileptic drug initially introduced in Europe, Japan and the United States (US) in the late 1980’s and was the first such drug to be clinically tested in the US, since ...

Atomic Absorption Spectrometric Determination of Certain Fluoroquinolones in Pharmaceutical Dosage Forms and in Biological Fluids

H. Salem — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.65.74

Simple, accurate, sensitive and selective methods are described for the quantitative determination of ten fluoroquinolones (amifloxacin, ciprofloxacin hydrochloride, difloxacin hydrochloride, enoxacin...

Sensitization of Photohemolysis by a New Extraction from Flowers and Aerial Parts of Cichorium Pumilum Jacq: Effects of Inulin and Hydrogen Peroxide

M-Ali H. Al-Akhras — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.75.79

Addition of inulin and hydrogen peroxide to new photosensitizers extracted from the flowers and aerial parts of the chicory (Cichorium Pumilum Jacq) have been investigated. Some of the isolated photos...

Curcuma longa, Glycyrrhiza glabra and Moringa oleifera Ameliorate Diclofenac-induced Hepatoxicity in Rats

Alaaeldin A. Hamza — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.80.88

Although treatment with therapeutic agents may be one of the main causes of liver toxicity, there have been only limited attempts at thorough research efforts to seek solution. Diclofenac (DIC) is a w...

Sorbitol-Induced Diabetic-Like Retinal Lesions in Rats: Microscopic Study

Gaber A. Ramadan — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.89.97

The present study investigated the sorbitol toxicity on the retinas of normal albino rats and founded by the light microscope that intra-peritoneal injection of Sorbitol (10-mg/kg-body weight per day)...

Insertion of poly (ethylene glycol)-lipid reduces the liposome-encapsulated hemoglobininduced thrombocytopenic reaction

Vibhudutta Awasthi — 2007-06-30

American Journal of Pharmacology and Toxicology, Published online: 30 June 2007; doi:10.3844/ajptsp.2007.98.105

Interaction with platelets has been recognized as a concern in the development of liposome-encapsulated hemoglobin as an oxygen carrier. This reaction causes a significant drop in circulating platelet...