Volume 4, Issue 1 (2008) | American Journal of Infectious Diseases

Immunopathogenesis of Dengue Hemorrhagic Fever

Huan-Yao Lei — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.1.9

Dengue virus infection causes Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) whose pathogeneses were not clearly understood. A new hypothesis of immunopathogenesis i...

High Case-Fatality Rate of Adults With Dengue Hemorrhagic Fever During An Outbreak In Non-Endemic Taiwan: Risk Factors For Dengue-Infected Elders

Ching-Chuan Liu — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.10.17

In 2002, a dengue outbreak occurred in Taiwan with 5336 confirmed cases, 242 DHF and 21 death, the case fatality rate reached 8.7% (21/242). The demographic data of these age-specific dengue patients ...

Correlation of IFN-Inducible Protein 10 Levels in Sera with Disease Severity and Clinical Outcome of the Dengue Patients

Ying-Ray Lee — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.18.21

Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reporte...

Dengue Virus Infection Induced NF-κB-dependent Macrophage Migration Inhibitory Factor Production

Lien-Cheng Chen — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.22.31

Dengue virus (DV) infection can cause mild dengue fever or severe dengue hemorrhage fever and dengue shock syndrome. Macrophage migration inhibitory factor (MIF) is a cytokine that plays an important ...

Signaling Pathways Involved In Dengue-2 Virus Infection Induced RANTES Overexpression

Ying-Ray Lee — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.32.40

Dengue viruses participate in liver inflammation by inducting the expression of various chemokines including Regulated on Activation Normal T-cell Expressed and Secreted (RANTES). However, the underly...

Anti-Platelet and Anti-Endothelial Cell Autoantibodies in Vietnamese Infants and Children with Dengue Hemorrhagic Fever

Nguyen Thanh Hung — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.41.49

Dengue hemorrhagic fever (DHF) is a serious public health problem. Increased vascular permeability and thrombocytopenia are the hallmarks of DHF. The mechanisms involved in DHF/Dengue shock syndrome (...

Generation of Anti-platelet Autoantibody During Dengue Virus Infection

Kao-Jean Huang — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.50.59

Dengue virus infection causes dengue fever, Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Thrombocytopenia is common in dengue fever and is always found in DHF/DSS. The pathogenesis ...

Anti-Prm Antibody as an Autoantibody in Dengue Virus Infection

Kao-Jean Huang — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.60.68

We have reported that anti-prM antibody is an enhancing antibody that enhances DV infection of non-Fc receptor bearing cells by dual specificity. We identified the epitope recognized by this anti-prM ...

Patient and Mouse Antibodies against Dengue Virus Nonstructural Protein 1 Cross-React with Platelets and Cause Their Dysfunction or Depletion

Chiou-Feng Lin — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.69.75

Thrombocytopenia is a clinical manifestation in dengue virus (DV) infection, yet its pathogenic mechanisms are unresolved. We previously showed that dengue patient sera contained antibodies cross-reac...

Epitope Mapping of Dengue-Virus-Enhancing Monoclonal-Antibody Using Phage Display Peptide Library

Chung-I Rai — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.76.84

The Antibody-Dependent Enhancement (ADE) hypothesis has been proposed to explain why more severe manifestations of Dengue Hemorrhagic Fever and Dengue Shock Syndrome (DHF/DSS) occur predominantly duri...

C-Terminal Region of Dengue Virus Nonstructural Protein 1 Is Involved in Endothelial Cell Cross-Reactivity via Molecular Mimicry

Shu-Wen Wan — 2008-03-31

American Journal of Infectious Diseases, Published online: 31 March 2008; doi:10.3844/ajidsp.2008.85.91

Infection with dengue virus (DV) causes diseases ranging from self-limited dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Vascular leakage, thrombocytopenia and b...